Detailed information NTG0463216

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: HW271_RS03730
• Genome accession: NZ_CP058258
• Coordinates: 757095..757736 (+)
• Length: 213 a.a.
• NCBI ID: WP_178894898.1
• Uniprot ID: A0A7H8Z8G6
• Organism: Streptococcus sp. oral taxon 061 strain F0704
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 752095..762736

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HW271_RS03700 (HW271_03700)	frr	752366..752923 (+)	558	WP_178894893.1	ribosome recycling factor	-
HW271_RS03705 (HW271_03705)	cvfB	752984..753838 (+)	855	WP_178894894.1	RNA-binding virulence regulatory protein CvfB	-
HW271_RS03710 (HW271_03710)	-	753847..754062 (+)	216	WP_001232087.1	YozE family protein	-
HW271_RS03715 (HW271_03715)	-	754147..755133 (+)	987	WP_178894895.1	PhoH family protein	-
HW271_RS03720 (HW271_03720)	ald	755182..756294 (-)	1113	WP_178894896.1	alanine dehydrogenase	-
HW271_RS03725 (HW271_03725)	-	756460..757029 (+)	570	WP_178894897.1	GNAT family N-acetyltransferase	-
HW271_RS03730 (HW271_03730)	comEA/celA/cilE	757095..757736 (+)	642	WP_178894898.1	helix-hairpin-helix domain-containing protein	Machinery gene
HW271_RS03735 (HW271_03735)	comEC/celB	757720..759930 (+)	2211	WP_178894899.1	ComEC/Rec2 family competence protein	Machinery gene
HW271_RS03740 (HW271_03740)	-	760053..761339 (+)	1287	WP_178894900.1	U32 family peptidase	-
HW271_RS03745 (HW271_03745)	-	761353..761664 (+)	312	WP_178894901.1	CHY zinc finger protein	-
HW271_RS03750 (HW271_03750)	-	761905..762105 (+)	201	WP_001054551.1	F0F1 ATP synthase subunit C	-

Sequence

Protein

• Length: 213 a.a.
• Molecular weight: 23262.29 Da
• Isoelectric Point: 4.9302

>NTDB_id=463216 HW271_RS03730 WP_178894898.1 757095..757736(+) (comEA/celA/cilE) [Streptococcus sp. oral taxon 061 strain F0704]
MEELIEKIKEYKIIVICASLGLVLGGFFLLKPVAQTPAKESNLQTEVTIVSKDSTDENEDKNQKEEVVEQDLITVDVKGA
VKSPGIYDLPVGSRINDAVQKAGGLTDNADSKSINLAQRISDEALVYVPTKEEATSQESQSNTSNNKESKKVNLNKASVE
ELKQVKGLGAKRAQDIIDHRESNGKFKSVDDLKKVSGIGAKTIEKLKEYVTVD

Nucleotide

• Length: 642 bp

>NTDB_id=463216 HW271_RS03730 WP_178894898.1 757095..757736(+) (comEA/celA/cilE) [Streptococcus sp. oral taxon 061 strain F0704]
ATGGAAGAACTTATTGAGAAAATCAAAGAATACAAAATCATTGTCATCTGCGCTAGTTTGGGTTTGGTCTTAGGTGGATT
TTTCCTCCTAAAACCAGTCGCTCAAACGCCTGCTAAGGAGAGTAATTTGCAGACTGAAGTTACAATTGTTTCAAAGGATT
CGACGGATGAAAATGAAGATAAAAATCAGAAAGAAGAAGTGGTAGAGCAAGATCTAATTACTGTCGATGTCAAAGGGGCT
GTTAAATCGCCAGGGATTTACGATTTGCCAGTTGGAAGTCGTATCAATGATGCTGTTCAAAAAGCTGGTGGACTGACAGA
TAATGCTGATAGTAAGTCTATCAATCTTGCCCAGAGAATTAGTGACGAAGCACTGGTCTATGTTCCGACCAAGGAAGAAG
CTACCAGTCAAGAATCACAATCAAATACCTCTAACAACAAGGAAAGTAAGAAAGTCAATCTCAATAAAGCCAGTGTAGAG
GAACTTAAACAAGTCAAAGGTTTAGGTGCGAAACGTGCGCAAGATATTATTGACCATCGTGAGTCTAACGGTAAGTTCAA
GTCAGTTGATGATCTCAAAAAGGTTTCTGGTATTGGTGCAAAAACGATAGAAAAGTTAAAAGAGTATGTCACAGTGGATT
AA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (75-124)

• Helix-hairpin-helix motif (HHH_3) (149-211)

3D structure

• AlphaFold DB: A0A7H8Z8G6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	78.241	100	0.793
comEA/celA/cilE	Streptococcus mitis NCTC 12261	77.778	100	0.789
comEA/celA/cilE	Streptococcus mitis SK321	76.389	100	0.775
comEA/celA/cilE	Streptococcus pneumoniae D39	75.926	100	0.77
comEA/celA/cilE	Streptococcus pneumoniae R6	75.926	100	0.77
comEA/celA/cilE	Streptococcus pneumoniae Rx1	75.926	100	0.77
comEA	Streptococcus thermophilus LMD-9	38.428	100	0.413
comEA	Lactococcus lactis subsp. cremoris KW2	38.496	100	0.408
comEA	Staphylococcus aureus N315	36.036	100	0.376
comEA	Staphylococcus aureus MW2	35.616	100	0.366