NTDB

Overview

Name	comE	Type	Regulator
Locus tag	FOC72_RS10345	Genome accession	NZ_CP054570
Coordinates	2122396..2123160 (+)	Length	254 a.a.
NCBI ID	WP_002894287.1	Uniprot ID	-
Organism	Streptococcus sanguinis strain FDAARGOS_770
Function	activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2117396..2128160

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOC72_RS10315 (FOC72_10315)	spo0J	2117942..2118703 (-)	762	WP_002894293.1	ParB/RepB/Spo0J family partition protein	Regulator
FOC72_RS10320 (FOC72_10320)	htrA	2118767..2119939 (-)	1173	WP_002894292.1	S1C family serine protease	Regulator
FOC72_RS10325 (FOC72_10325)	rlmH	2120144..2120623 (+)	480	WP_002894291.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FOC72_RS10335 (FOC72_10335)	-	2120920..2121027 (+)	108	WP_002894290.1	hypothetical protein	-
FOC72_RS10340 (FOC72_10340)	comD	2121056..2122390 (+)	1335	WP_002894289.1	competence system sensor histidine kinase ComD	-
FOC72_RS10345 (FOC72_10345)	comE	2122396..2123160 (+)	765	WP_002894287.1	competence system response regulator transcription factor ComE	Regulator
FOC72_RS10360 (FOC72_10360)	-	2123444..2126029 (-)	2586	WP_002894285.1	YfhO family protein	-
FOC72_RS10365 (FOC72_10365)	-	2126105..2127727 (-)	1623	WP_002894283.1	ATP-binding cassette domain-containing protein	-

Sequence

Protein

Download Length: 254 a.a. Molecular weight: 29850.15 Da Isoelectric Point: 8.5702

                                >NTDB_id=453529 FOC72_RS10345 WP_002894287.1 2122396..2123160(+) (comE) [Streptococcus sanguinis strain FDAARGOS_770]

MKVLVLEDTVSHQVRMETTLAEIAEELGIDIQVQVTGKIKEFKKYIENGDVNQLYFLDIDIKGEETKGLEVAQFIRHHNP

YAIIVFVTSKSEFATMTFKYKVSALDFINKDINNDAFKNRIKDSILYTKSTLIENTNMVDYFEYSYRGNDVRMPYNDILY

IETTGSSHKLRIVGKNFLKEFYGTITDIQEKDQQSKRFFSPHKSYLVNIGNIVDYDKKNREIIFYENHRCPVTRLRVKYL

KDIFENKGKRVDKA

Nucleotide

Download Length: 765 bp

                                >NTDB_id=453529 FOC72_RS10345 WP_002894287.1 2122396..2123160(+) (comE) [Streptococcus sanguinis strain FDAARGOS_770]

ATGAAAGTGTTAGTTTTAGAGGATACCGTATCTCATCAAGTCAGGATGGAAACGACATTAGCAGAAATTGCTGAGGAACT

TGGAATTGACATCCAGGTTCAGGTTACAGGAAAAATCAAAGAATTCAAAAAATATATTGAAAATGGAGACGTTAACCAGC

TTTATTTTTTGGATATTGACATTAAAGGAGAGGAAACAAAAGGGCTGGAAGTAGCTCAATTTATACGTCATCATAATCCT

TATGCCATTATAGTTTTTGTAACCTCAAAATCTGAATTTGCTACTATGACTTTTAAATATAAAGTATCAGCACTTGATTT

TATCAATAAAGATATCAACAATGATGCTTTTAAAAATAGAATCAAAGACAGTATTCTTTACACTAAGAGTACACTAATTG

AAAATACCAATATGGTAGATTATTTTGAATATAGTTATCGTGGCAATGATGTTCGAATGCCTTATAACGATATTTTGTAT

ATCGAAACGACAGGGAGCTCTCATAAACTTCGGATTGTCGGTAAAAATTTTCTTAAGGAATTTTATGGAACGATAACAGA

TATTCAAGAAAAAGATCAGCAATCTAAACGATTTTTTTCACCACATAAATCTTATCTGGTTAATATTGGCAACATTGTTG

ATTATGATAAGAAAAATCGAGAAATTATTTTTTACGAAAATCATCGCTGTCCGGTCACTCGTTTAAGAGTGAAATATCTG

AAAGATATTTTCGAAAATAAAGGGAAAAGAGTTGACAAAGCTTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-244)

Response regulator receiver domain (Response_reg)

(4-121)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE	Streptococcus infantis strain Atu-4	68	98.425	0.669
comE/comE2	Streptococcus gordonii strain NCTC7865	68	98.425	0.669
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	68	98.425	0.669
comE	Streptococcus mitis NCTC 12261	67.6	98.425	0.665
comE	Streptococcus mitis SK321	66.8	98.425	0.657
comE	Streptococcus pneumoniae Rx1	66.4	98.425	0.654
comE	Streptococcus pneumoniae D39	66.4	98.425	0.654
comE	Streptococcus pneumoniae R6	66.4	98.425	0.654
comE	Streptococcus pneumoniae TIGR4	66.4	98.425	0.654
comE/blpR	Streptococcus mutans UA159	38.4	98.425	0.378

Detailed information NTG0453529