Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   FOC72_RS10320 Genome accession   NZ_CP054570
Coordinates   2118767..2119939 (-) Length   390 a.a.
NCBI ID   WP_002894292.1    Uniprot ID   -
Organism   Streptococcus sanguinis strain FDAARGOS_770     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2113767..2124939
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOC72_RS10295 (FOC72_10295) - 2114140..2114631 (+) 492 WP_002894297.1 DUF1307 domain-containing protein -
  FOC72_RS10300 (FOC72_10300) - 2114759..2114953 (-) 195 WP_002894296.1 DUF951 domain-containing protein -
  FOC72_RS10305 (FOC72_10305) dnaN 2115081..2116217 (-) 1137 WP_002894295.1 DNA polymerase III subunit beta -
  FOC72_RS10310 (FOC72_10310) dnaA 2116376..2117728 (-) 1353 WP_002894294.1 chromosomal replication initiator protein DnaA -
  FOC72_RS10315 (FOC72_10315) spo0J 2117942..2118703 (-) 762 WP_002894293.1 ParB/RepB/Spo0J family partition protein Regulator
  FOC72_RS10320 (FOC72_10320) htrA 2118767..2119939 (-) 1173 WP_002894292.1 S1C family serine protease Regulator
  FOC72_RS10325 (FOC72_10325) rlmH 2120144..2120623 (+) 480 WP_002894291.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FOC72_RS10335 (FOC72_10335) - 2120920..2121027 (+) 108 WP_002894290.1 hypothetical protein -
  FOC72_RS10340 (FOC72_10340) comD 2121056..2122390 (+) 1335 WP_002894289.1 competence system sensor histidine kinase ComD -
  FOC72_RS10345 (FOC72_10345) comE 2122396..2123160 (+) 765 WP_002894287.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 390 a.a.        Molecular weight: 40903.65 Da        Isoelectric Point: 4.7432

>NTDB_id=453528 FOC72_RS10320 WP_002894292.1 2118767..2119939(-) (htrA) [Streptococcus sanguinis strain FDAARGOS_770]
MKNSSNAIKRALFLFAVLIVGFIGGSLGNYVTTLLTSRVKMNGNSTTSVTTSYKNSTDISEAVKKVQNAVVSVITYAESS
SSVINDESSNDESQISSEGSGVIYKKDGKSAYLVTNTHVLNGSTNVDILLADGNKVPGEVVGSDVYSDISVVKISSEKVT
DVAEFGDSGSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSENGENISTTALQTDAAINPGNSGGPLINIQGQ
VIGITSSKISTNGQTSVEGMGFAIPSNDVVNIINQLEKNGTVTRPALGIQMMDLSNLTTSDFSKLNLPSSVKSGILVRSV
QQGMPADGKLQKNDVITKVDNTDVESTSDLQSALYKHSIGDEVEITYYRDGKSQTVKIKLTKSTKELSSN

Nucleotide


Download         Length: 1173 bp        

>NTDB_id=453528 FOC72_RS10320 WP_002894292.1 2118767..2119939(-) (htrA) [Streptococcus sanguinis strain FDAARGOS_770]
ATGAAAAATTCTTCAAATGCCATCAAAAGGGCTTTATTTCTTTTTGCAGTATTAATTGTAGGTTTTATCGGCGGAAGTTT
AGGAAATTATGTTACTACATTATTAACTTCACGTGTAAAAATGAATGGAAATTCAACAACCAGTGTAACTACTTCATATA
AAAACTCTACTGACATTTCAGAAGCTGTGAAAAAGGTTCAAAATGCCGTTGTTTCAGTAATTACTTATGCTGAATCTTCC
AGCAGCGTTATCAATGATGAATCTTCCAACGATGAATCACAAATCTCCAGTGAAGGTTCTGGCGTAATTTATAAAAAAGA
TGGAAAATCAGCCTATCTGGTAACCAACACCCACGTTCTTAATGGATCAACCAATGTAGATATCTTACTAGCTGATGGAA
ACAAGGTTCCAGGTGAAGTAGTTGGATCAGATGTTTATTCAGATATCTCTGTCGTTAAAATTAGTTCTGAAAAAGTAACT
GATGTCGCTGAATTTGGAGATTCTGGTTCTCTTACAGTTGGTGAAACAGCAATCGCTATCGGAAGCCCTCTTGGAACAGA
ATACGCTAACTCTGTCACACAAGGAATTATTTCTAGTTTAGGCAGAAACGTTACGTTACAATCTGAAAATGGTGAAAATA
TTTCAACAACTGCATTGCAAACAGATGCTGCAATCAATCCTGGTAACTCTGGCGGCCCGTTGATTAACATCCAAGGACAA
GTTATTGGGATTACTTCAAGTAAGATTTCAACAAATGGGCAAACCTCTGTTGAAGGGATGGGATTTGCGATTCCGTCTAA
TGATGTCGTAAATATTATCAATCAACTTGAAAAAAATGGAACAGTCACACGTCCTGCTTTAGGAATTCAAATGATGGATT
TATCTAATCTGACAACTTCTGATTTTTCTAAATTAAATCTTCCTTCTTCAGTGAAATCAGGTATTCTTGTTCGCTCTGTT
CAGCAAGGAATGCCTGCTGATGGCAAACTTCAAAAAAATGATGTCATTACAAAAGTAGATAACACAGATGTGGAATCCAC
TAGTGACCTTCAGTCTGCTCTCTACAAGCATAGCATTGGAGATGAGGTAGAGATTACTTATTATCGAGATGGTAAATCTC
AAACAGTCAAAATCAAACTCACTAAATCAACAAAAGAGTTAAGCTCAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(231-385)

Trypsin-like peptidase domain (Trypsin_2)

(99-244)

PDZ domain (PDZ_2)

(285-380)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

67.172

100

0.682
  htrA Streptococcus mitis NCTC 12261

64.122

100

0.646
  htrA Streptococcus pneumoniae Rx1

64.122

100

0.646
  htrA Streptococcus pneumoniae D39

64.122

100

0.646
  htrA Streptococcus pneumoniae R6

64.122

100

0.646
  htrA Streptococcus pneumoniae TIGR4

64.122

100

0.646
  htrA Streptococcus mutans UA159

54.684

100

0.554