Detailed information NTG0431242

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: HB750_RS00455
• Genome accession: NZ_CP050273
• Coordinates: 93799..94551 (+)
• Length: 250 a.a.
• NCBI ID: WP_002298154.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain P1
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 88799..99551

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HB750_RS00435 (HB750_00435)	dnaI	89719..90618 (+)	900	WP_002273096.1	primosomal protein DnaI	-
HB750_RS00440 (HB750_00440)	der	90631..91941 (+)	1311	WP_019804906.1	ribosome biogenesis GTPase Der	-
HB750_RS00445 (HB750_00445)	-	92016..92642 (+)	627	WP_002273094.1	hypothetical protein	-
HB750_RS00450 (HB750_00450)	-	92690..93328 (+)	639	WP_002271525.1	VTT domain-containing protein	-
HB750_RS00455 (HB750_00455)	comE/blpR	93799..94551 (+)	753	WP_002298154.1	response regulator transcription factor	Regulator
HB750_RS00460 (HB750_00460)	-	94548..95874 (+)	1327	Protein_88	sensor histidine kinase	-
HB750_RS00465 (HB750_00465)	comC/blpC	96016..96156 (-)	141	WP_002270250.1	ComC/BlpC family leader-containing pheromone/bacteriocin	Regulator
HB750_RS00470 (HB750_00470)	cipB	96424..96654 (+)	231	WP_002309764.1	Blp family class II bacteriocin	Regulator
HB750_RS00475 (HB750_00475)	-	96785..97186 (+)	402	WP_002310604.1	hypothetical protein	-
HB750_RS00480 (HB750_00480)	-	98566..98985 (+)	420	WP_019804903.1	hypothetical protein	-
HB750_RS00485 (HB750_00485)	-	99132..99536 (+)	405	WP_002263912.1	hypothetical protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29331.68 Da
• Isoelectric Point: 8.2551

>NTDB_id=431242 HB750_RS00455 WP_002298154.1 93799..94551(+) (comE/blpR) [Streptococcus mutans strain P1]
MISIFVLEDDFLQQGRLETTIAAIMKEKNWSYKELTIFGKPQQLIDAIPEKGSHQIFFLDIEIKKEEKKGLEVANQIRQH
NPSAVIVFVTTHSEFMPLTFQYQVSALDFIDKSLNPEEFSHRIESALYYAMENSQKNGQSEELFIFHSSETQFQVPFAEI
LYFETSSTAHKLCLYTYDERIEFYGSMTDIVKMDKRLFQCHRSFIVNPANITRIDRKKRLAYFRNNKSCLISRTKLTKLR
AVIADQRRAK

Nucleotide

• Length: 753 bp

>NTDB_id=431242 HB750_RS00455 WP_002298154.1 93799..94551(+) (comE/blpR) [Streptococcus mutans strain P1]
ATGATTTCTATTTTTGTATTGGAAGATGATTTTTTACAACAAGGACGTCTTGAAACCACCATTGCAGCTATCATGAAAGA
AAAAAATTGGTCTTATAAAGAATTGACTATTTTTGGAAAACCACAACAACTTATTGACGCTATCCCTGAAAAGGGCAGTC
ACCAGATTTTCTTTTTGGATATTGAAATCAAAAAAGAGGAAAAGAAAGGACTGGAAGTAGCCAATCAGATTAGACAGCAT
AATCCTAGTGCGGTTATTGTCTTTGTCACGACACATTCTGAGTTTATGCCCCTCACTTTTCAGTATCAGGTATCTGCTTT
GGATTTTATTGATAAATCTTTGAATCCTGAGGAGTTCTCCCACCGCATTGAATCAGCGCTGTATTATGCTATGGAAAACA
GCCAGAAGAATGGTCAATCAGAGGAACTTTTTATTTTCCATTCATCTGAAACTCAGTTTCAGGTCCCTTTTGCTGAGATT
CTGTATTTTGAAACATCTTCAACAGCCCATAAGCTCTGCCTTTATACTTATGATGAACGGATTGAATTTTATGGTAGTAT
GACTGACATTGTTAAAATGGATAAGAGACTTTTTCAGTGCCATCGCTCTTTTATTGTCAATCCTGCCAATATTACCCGTA
TTGATCGGAAAAAGCGATTGGCTTATTTTCGAAATAATAAGTCTTGTCTTATTTCACGAACTAAGTTAACAAAACTGAGA
GCTGTGATTGCTGATCAAAGGAGAGCAAAATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (153-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	99.6	100	0.996
comE/comE1	Streptococcus equinus JB1	46.473	96.4	0.448
comE	Streptococcus mitis NCTC 12261	41.7	98.8	0.412
comE	Streptococcus infantis strain Atu-4	41.7	98.8	0.412
comE	Streptococcus pneumoniae Rx1	41.296	98.8	0.408
comE	Streptococcus mitis SK321	41.296	98.8	0.408
comE	Streptococcus pneumoniae D39	41.296	98.8	0.408
comE	Streptococcus pneumoniae R6	41.296	98.8	0.408
comE	Streptococcus pneumoniae TIGR4	41.296	98.8	0.408
comE/comE2	Streptococcus equinus JB1	40.664	96.4	0.392
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.551	98	0.368
comE/comE2	Streptococcus gordonii strain NCTC7865	37.551	98	0.368