Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   HB753_RS00085 Genome accession   NZ_CP050270
Coordinates   22353..23294 (+) Length   313 a.a.
NCBI ID   WP_019804919.1    Uniprot ID   -
Organism   Streptococcus mutans strain S4     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 17353..28294
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HB753_RS00075 (HB753_00075) rpoC 18083..21712 (+) 3630 WP_002263433.1 DNA-directed RNA polymerase subunit beta' -
  HB753_RS00080 (HB753_00080) - 21840..22223 (+) 384 WP_002263434.1 DUF1033 family protein -
  HB753_RS00085 (HB753_00085) comYA 22353..23294 (+) 942 WP_019804919.1 competence type IV pilus ATPase ComGA Machinery gene
  HB753_RS00090 (HB753_00090) comYB 23230..24261 (+) 1032 WP_255262721.1 competence type IV pilus assembly protein ComGB Machinery gene
  HB753_RS00095 (HB753_00095) comYC 24261..24575 (+) 315 WP_002263437.1 competence type IV pilus major pilin ComGC Machinery gene
  HB753_RS00100 (HB753_00100) comYD 24562..24966 (+) 405 WP_002263438.1 competence type IV pilus minor pilin ComGD Machinery gene
  HB753_RS00105 (HB753_00105) comYE 24938..25231 (+) 294 WP_002263439.1 competence type IV pilus minor pilin ComGE Machinery gene
  HB753_RS00110 (HB753_00110) comYF 25218..25652 (+) 435 WP_002274770.1 competence type IV pilus minor pilin ComGF Machinery gene
  HB753_RS00115 (HB753_00115) comYG 25630..26019 (+) 390 WP_002263441.1 competence type IV pilus minor pilin ComGG Machinery gene
  HB753_RS00120 (HB753_00120) comYH 26074..27027 (+) 954 WP_019317550.1 class I SAM-dependent methyltransferase Machinery gene
  HB753_RS00125 (HB753_00125) - 27086..28285 (+) 1200 WP_002263443.1 acetate kinase -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35753.12 Da        Isoelectric Point: 8.0347

>NTDB_id=431018 HB753_RS00085 WP_019804919.1 22353..23294(+) (comYA) [Streptococcus mutans strain S4]
MVQKLGRKIIAEAVQNKAQDIYIIPKKESYELYMRIGNERRFIDVYDHHFMANLISHFKFVAGMNVGEKRRSQLGSCDYS
YDEGKVISLRLSSVGDYRGYESLVIRLLFSGRHDLKFWFNSMDLILNEIKGRGLYLFSGPVGSGKTSLMYQLVKLRFETK
QVITIEDPVEIKQDNMLQLQLNESIDMTYDNLIKLSLRHRPDILIIGEIRDKETARAVIRASLTGAMIFSTIHAKSIPGV
YARMLELGTSSEELQNALRGIVYQRLIGGGGIIDFAKGDYQNHSAKKWNKQIYDLFTAGYITEGEAQAEEIED

Nucleotide


Download         Length: 942 bp        

>NTDB_id=431018 HB753_RS00085 WP_019804919.1 22353..23294(+) (comYA) [Streptococcus mutans strain S4]
ATGGTTCAAAAATTAGGTAGAAAAATCATTGCCGAAGCTGTTCAAAATAAAGCACAAGATATCTATATTATTCCTAAAAA
AGAATCTTATGAGCTTTATATGAGAATAGGGAATGAAAGGAGGTTCATTGATGTTTATGACCATCATTTCATGGCTAATC
TTATTAGTCACTTTAAATTTGTTGCAGGAATGAATGTTGGTGAGAAAAGACGAAGTCAGCTGGGCTCTTGTGATTATTCT
TATGATGAAGGGAAAGTTATTTCATTAAGGTTATCAAGTGTAGGAGATTATCGTGGTTATGAAAGTTTGGTTATTCGCTT
ACTTTTTTCTGGACGTCACGATTTAAAATTCTGGTTTAACAGTATGGATTTGATTTTAAATGAAATCAAGGGGCGAGGGC
TTTATCTTTTTTCGGGTCCAGTTGGAAGTGGCAAAACAAGTTTGATGTATCAATTGGTAAAACTAAGATTTGAGACCAAA
CAGGTAATTACCATTGAAGATCCTGTGGAAATTAAGCAAGATAATATGTTACAACTGCAGCTTAATGAAAGCATTGATAT
GACTTATGATAATTTAATTAAATTATCTCTGAGGCATCGTCCGGATATTTTAATTATTGGAGAAATTCGAGATAAAGAAA
CCGCCAGAGCTGTTATTAGAGCAAGTCTTACAGGGGCAATGATATTCTCAACTATCCATGCTAAAAGCATTCCAGGTGTT
TATGCTAGGATGTTAGAATTGGGTACTAGTTCAGAAGAATTACAAAATGCTTTGCGTGGTATTGTTTATCAACGTTTAAT
AGGGGGAGGAGGGATTATTGACTTTGCCAAAGGGGATTATCAAAACCACTCAGCAAAAAAGTGGAACAAACAAATTTATG
ACCTTTTTACAGCAGGATATATCACTGAAGGAGAAGCACAAGCAGAAGAAATTGAAGATTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(8-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

99.681

100

0.997
  comYA Streptococcus mutans UA140

99.361

100

0.994
  comYA Streptococcus gordonii str. Challis substr. CH1

66.773

100

0.668
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

65.705

99.681

0.655
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

65.595

99.361

0.652
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

65.595

99.361

0.652
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

65.595

99.361

0.652
  comGA/cglA/cilD Streptococcus pneumoniae D39

65.595

99.361

0.652
  comGA/cglA/cilD Streptococcus pneumoniae R6

65.595

99.361

0.652
  comGA Lactococcus lactis subsp. cremoris KW2

52.09

99.361

0.518