Detailed information NTG0430219

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: HBA50_RS06045
• Genome accession: NZ_CP050133
• Coordinates: 1208580..1209311 (-)
• Length: 243 a.a.
• NCBI ID: WP_045499622.1
• Uniprot ID: -
• Organism: Streptococcus cristatus ATCC 51100
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1203580..1214311

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HBA50_RS06025 (HBA50_06025)	-	1204092..1205252 (-)	1161	WP_045499634.1	ABC transporter permease subunit	-
HBA50_RS06030 (HBA50_06030)	-	1205249..1206112 (-)	864	WP_045499631.1	ABC transporter ATP-binding protein	-
HBA50_RS06040 (HBA50_06040)	-	1207210..1208547 (-)	1338	WP_045499625.1	sensor histidine kinase	-
HBA50_RS06045 (HBA50_06045)	comE/blpR	1208580..1209311 (-)	732	WP_045499622.1	response regulator transcription factor	Regulator
HBA50_RS06050 (HBA50_06050)	-	1209313..1209654 (-)	342	WP_045499619.1	LytTR family DNA-binding domain-containing protein	-
HBA50_RS06055 (HBA50_06055)	-	1209838..1210410 (-)	573	WP_045499617.1	TetR/AcrR family transcriptional regulator	-
HBA50_RS06060 (HBA50_06060)	-	1210537..1211379 (+)	843	WP_045499615.1	DegV family protein	-
HBA50_RS06065 (HBA50_06065)	-	1211470..1212246 (+)	777	WP_045499613.1	XRE family transcriptional regulator	-
HBA50_RS06070 (HBA50_06070)	-	1212264..1212698 (-)	435	WP_243746220.1	hypothetical protein	-
HBA50_RS06075 (HBA50_06075)	-	1212813..1213295 (-)	483	WP_045499609.1	hypothetical protein	-
HBA50_RS06080 (HBA50_06080)	-	1213288..1213833 (-)	546	WP_045499606.1	DUF1697 domain-containing protein	-

Sequence

Protein

• Length: 243 a.a.
• Molecular weight: 28786.91 Da
• Isoelectric Point: 5.4506

>NTDB_id=430219 HBA50_RS06045 WP_045499622.1 1208580..1209311(-) (comE/blpR) [Streptococcus cristatus ATCC 51100]
MKIFVLEDDLKQQAYMESTIQGILEKNGWECHFLEIYGKPDMLIDAVRERGSHQIFFLDIEIKQETQKGLEVAGKIRKLD
PYALIVFVTTHSEFMPLTFRYQVSAFDFIDKGLPEEDFIKQIEQDLAYLYERKDSFQAEETFLFENSKSDFQVPFNEIYY
FETSEVPHRLVLYTKKERIEFYGQLSEITKQDKRLYRCHRSYVVNPANISQLDKIENIAYFPNGASCYVSRLKMKGLRTA
LRQ

Nucleotide

• Length: 732 bp

>NTDB_id=430219 HBA50_RS06045 WP_045499622.1 1208580..1209311(-) (comE/blpR) [Streptococcus cristatus ATCC 51100]
ATGAAAATTTTTGTATTAGAAGATGATCTTAAGCAACAAGCCTATATGGAGTCAACCATTCAGGGGATTCTGGAAAAGAA
TGGCTGGGAATGCCATTTTTTAGAAATCTATGGCAAGCCGGACATGCTGATTGATGCAGTAAGGGAACGGGGGAGCCATC
AGATTTTCTTTTTGGATATTGAGATTAAGCAAGAGACGCAGAAGGGACTAGAGGTGGCAGGAAAGATTCGCAAGTTGGAC
CCCTATGCTCTGATTGTATTTGTGACGACTCACTCAGAATTTATGCCCTTGACTTTTCGCTATCAGGTATCAGCTTTTGA
CTTTATTGATAAAGGTTTGCCTGAGGAAGATTTTATCAAGCAGATTGAGCAGGACTTGGCCTATCTTTACGAGAGAAAGG
ACAGCTTTCAAGCTGAGGAAACTTTTCTCTTTGAAAATTCTAAGTCGGATTTTCAGGTGCCTTTTAATGAAATCTATTAT
TTTGAGACATCAGAAGTGCCTCATAGACTAGTTCTCTATACCAAGAAAGAGCGCATCGAATTTTACGGACAACTTTCTGA
GATTACAAAGCAGGACAAGCGTCTCTATCGGTGTCATCGCTCTTATGTGGTCAATCCAGCGAATATCTCTCAGCTGGATA
AGATAGAAAACATAGCCTATTTTCCTAATGGCGCTAGTTGCTATGTATCACGCCTCAAGATGAAAGGATTACGGACAGCT
TTAAGGCAGTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	57.025	99.588	0.568
comE/comE1	Streptococcus equinus JB1	45.455	99.588	0.453
comE/comE2	Streptococcus equinus JB1	43.983	99.177	0.436
comE/comE2	Streptococcus gordonii strain NCTC7865	37.751	100	0.387
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.751	100	0.387
comE	Streptococcus infantis strain Atu-4	36.4	100	0.374
comE	Streptococcus mitis NCTC 12261	35.6	100	0.366
comE	Streptococcus pneumoniae Rx1	35.6	100	0.366
comE	Streptococcus pneumoniae D39	35.6	100	0.366
comE	Streptococcus pneumoniae R6	35.6	100	0.366
comE	Streptococcus pneumoniae TIGR4	35.6	100	0.366
comE	Streptococcus mitis SK321	35.6	100	0.366