Detailed information NTG0430183

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: HBA50_RS00050
• Genome accession: NZ_CP050133
• Coordinates: 7573..8316 (+)
• Length: 247 a.a.
• NCBI ID: WP_045499902.1
• Uniprot ID: -
• Organism: Streptococcus cristatus ATCC 51100
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	8683..13260	7573..8316	flank	367

Gene organization within MGE regions

Location: 7573..13260

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HBA50_RS00050 (HBA50_00050)	comE/comE2	7573..8316 (+)	744	WP_045499902.1	competence system response regulator transcription factor ComE	Regulator
HBA50_RS00065 (HBA50_00065)	-	8683..10077 (+)	1395	WP_166492625.1	IS1182 family transposase	-
HBA50_RS00070 (HBA50_00070)	sdaAA	10172..11044 (-)	873	WP_045499908.1	L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha	-
HBA50_RS00075 (HBA50_00075)	sdaAB	11053..11724 (-)	672	WP_045499905.1	L-serine ammonia-lyase, iron-sulfur-dependent subunit beta	-
HBA50_RS00080 (HBA50_00080)	-	11757..13260 (-)	1504	Protein_12	IS1182 family transposase	-

Sequence

Protein

• Length: 247 a.a.
• Molecular weight: 29097.37 Da
• Isoelectric Point: 7.3958

>NTDB_id=430183 HBA50_RS00050 WP_045499902.1 7573..8316(+) (comE/comE2) [Streptococcus cristatus ATCC 51100]
MRILALEDTLAHQVRMEKTLAEIAEEMGLDIQVKITGKIQEFKDYVENEDVNQIYFLDIDIKGEETKGLEVARFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINDDSFKKRIKDCIIYTKNTLITNTNMVDYFEYSYRGNDVRVPFNDILY
IETSSSSHKLRMVGKNFIKEFYGTIASVQEQDEKTQRFFASHKSFLVNIDNICDYDKKTKEIIFYEGRRCPVSRLRTKHL
KEILKNK

Nucleotide

• Length: 744 bp

>NTDB_id=430183 HBA50_RS00050 WP_045499902.1 7573..8316(+) (comE/comE2) [Streptococcus cristatus ATCC 51100]
ATGAGAATCTTAGCATTAGAAGATACTTTAGCCCACCAAGTCCGCATGGAAAAAACTTTAGCAGAGATTGCTGAAGAAAT
GGGTCTCGATATCCAGGTAAAAATCACAGGAAAAATTCAGGAATTTAAGGACTACGTCGAAAATGAAGATGTCAATCAGA
TTTATTTTCTGGATATAGATATTAAAGGGGAAGAGACCAAAGGACTGGAGGTCGCTCGTTTTATTCGTCATCATAATCCA
TATGCTATTATTGTCTTTGTAACTTCAAAATCAGAGTTTGCGACCATGACCTTTAAATATAAAGTATCTGCTCTTGATTT
TATTGATAAGGATATTAACGATGATTCGTTTAAAAAACGTATCAAAGATTGTATCATTTATACGAAAAACACCTTAATTA
CAAACACCAATATGGTTGATTACTTTGAATACAGCTATCGAGGCAATGATGTGCGCGTGCCATTTAATGATATTTTGTAT
ATCGAAACCTCAAGCTCCTCCCATAAGTTACGGATGGTCGGAAAAAACTTTATAAAAGAATTTTATGGAACGATTGCCAG
TGTTCAAGAACAGGATGAGAAAACCCAACGTTTCTTTGCTTCCCATAAATCTTTCTTAGTCAATATCGATAATATCTGCG
ATTATGATAAGAAAACAAAGGAAATTATATTTTATGAAGGCCGTCGTTGCCCTGTTTCTAGGCTAAGAACAAAACATTTA
AAAGAAATTTTAAAAAATAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (18-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	69.231	100	0.692
comE/comE2	Streptococcus gordonii strain NCTC7865	69.231	100	0.692
comE	Streptococcus mitis NCTC 12261	62.753	100	0.628
comE	Streptococcus mitis SK321	61.943	100	0.619
comE	Streptococcus pneumoniae TIGR4	61.538	100	0.615
comE	Streptococcus pneumoniae D39	61.538	100	0.615
comE	Streptococcus infantis strain Atu-4	61.538	100	0.615
comE	Streptococcus pneumoniae Rx1	61.538	100	0.615
comE	Streptococcus pneumoniae R6	61.538	100	0.615
comE/blpR	Streptococcus mutans UA159	39.919	100	0.401
comE/comE1	Streptococcus equinus JB1	38.306	100	0.385
comE/comE2	Streptococcus equinus JB1	37.551	99.19	0.372