Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SALIVB_RS02340 Genome accession   NC_015760
Coordinates   447627..448370 (-) Length   247 a.a.
NCBI ID   WP_002886749.1    Uniprot ID   -
Organism   Streptococcus salivarius CCHSS3     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 440945..463641 447627..448370 within 0
IScluster/Tn 440945..450368 447627..448370 within 0


Gene organization within MGE regions


Location: 440945..463641
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SALIVB_RS02300 (SALIVB_0460) tnpA 440945..441193 (+) 249 Protein_394 IS200/IS605 family transposase -
  SALIVB_RS02305 (SALIVB_0461) - 441284..442270 (+) 987 WP_002886406.1 IS30 family transposase -
  SALIVB_RS02310 (SALIVB_0462) - 442337..442504 (+) 168 WP_013990154.1 hypothetical protein -
  SALIVB_RS02315 (SALIVB_0463) - 442498..443178 (+) 681 WP_014633514.1 hypothetical protein -
  SALIVB_RS02320 (SALIVB_0464) - 443497..444156 (+) 660 WP_013990156.1 ABC transporter ATP-binding protein -
  SALIVB_RS02325 (SALIVB_0465) - 444171..444887 (+) 717 WP_041817342.1 hypothetical protein -
  SALIVB_RS02330 (SALIVB_0467) tnpA 445126..445590 (+) 465 WP_002883780.1 IS200/IS605 family transposase -
  SALIVB_RS02335 (SALIVB_0469) - 446310..447377 (-) 1068 WP_231844796.1 sensor histidine kinase -
  SALIVB_RS02340 (SALIVB_0470) comE/blpR 447627..448370 (-) 744 WP_002886749.1 response regulator transcription factor Regulator
  SALIVB_RS10965 (SALIVB_0471) - 448870..449223 (+) 354 WP_013990160.1 hypothetical protein -
  SALIVB_RS02355 (SALIVB_0473) tnpA 449895..450368 (+) 474 WP_013990162.1 IS200/IS605 family transposase -
  SALIVB_RS02360 (SALIVB_0474) - 450629..451015 (+) 387 WP_013990163.1 helix-turn-helix domain-containing protein -
  SALIVB_RS02365 (SALIVB_0475) - 451151..451843 (+) 693 WP_013990164.1 DUF6287 domain-containing protein -
  SALIVB_RS02370 (SALIVB_0476) - 451908..452198 (+) 291 WP_002885564.1 hypothetical protein -
  SALIVB_RS02375 (SALIVB_0477) - 452485..455067 (+) 2583 WP_013990165.1 SH3 domain-containing protein -
  SALIVB_RS02380 (SALIVB_0478) - 455270..456022 (+) 753 WP_002886759.1 response regulator transcription factor -
  SALIVB_RS02385 (SALIVB_0479) - 456157..456822 (+) 666 WP_002886760.1 DUF6287 domain-containing protein -
  SALIVB_RS02390 (SALIVB_0480) comE/blpR 457070..457804 (+) 735 WP_013990166.1 response regulator transcription factor Regulator
  SALIVB_RS02395 (SALIVB_0481) - 457801..459120 (+) 1320 WP_013990167.1 GHKL domain-containing protein -
  SALIVB_RS02400 (SALIVB_0482) - 459218..459784 (+) 567 WP_013990168.1 transcriptional regulator -
  SALIVB_RS02405 (SALIVB_0483) ldcB 460075..463641 (+) 3567 WP_013990169.1 LD-carboxypeptidase LdcB/DacB -

Sequence

Protein


Download         Length: 247 a.a.        Molecular weight: 28781.30 Da        Isoelectric Point: 7.0440

>NTDB_id=41811 SALIVB_RS02340 WP_002886749.1 447627..448370(-) (comE/blpR) [Streptococcus salivarius CCHSS3]
MLNIFILEDDFLQQSRIETVIKDVISKKSLKCKGPEIYGKPSQLLDAITERGSHQLFFLDIEIKGEEKKGLDIAKEIRKK
DPNATIVFVTTHSEFMPVTFKYRVAALDFIDKALNDEFFYERVRLAIEYTMDKLGATITQDSFTFETSMAHVQVPFNNIL
FFETSPTIHKVILHTKEERMEFYASISEVERADERLYRCHRSFIVNPENILKINKEEKMAMFDNNIGCPISRTKYRGLLE
KVKSMKS

Nucleotide


Download         Length: 744 bp        

>NTDB_id=41811 SALIVB_RS02340 WP_002886749.1 447627..448370(-) (comE/blpR) [Streptococcus salivarius CCHSS3]
TTGTTAAATATTTTTATTTTAGAAGATGATTTCTTACAACAATCACGAATAGAAACAGTTATTAAGGATGTTATTTCAAA
AAAATCTCTAAAATGTAAAGGACCTGAGATTTATGGAAAACCTAGCCAATTACTTGACGCAATTACCGAAAGAGGCTCTC
ACCAACTTTTCTTTTTAGATATTGAAATCAAGGGTGAAGAAAAGAAGGGGCTAGACATTGCTAAAGAAATTCGAAAAAAA
GATCCTAATGCAACAATTGTTTTTGTAACAACACACTCAGAATTCATGCCAGTCACTTTTAAATATAGAGTTGCTGCCCT
AGATTTTATTGATAAAGCTTTGAATGATGAGTTTTTTTATGAACGTGTCCGTTTAGCAATTGAATATACTATGGATAAAC
TGGGGGCTACCATTACCCAAGATTCATTTACTTTTGAAACATCAATGGCCCACGTTCAAGTGCCTTTTAACAATATTTTA
TTTTTTGAAACGTCTCCAACAATACATAAGGTTATTTTGCATACTAAAGAAGAAAGAATGGAGTTTTACGCAAGTATTTC
AGAAGTTGAGCGTGCTGACGAACGCTTATATCGATGCCATCGTTCGTTTATCGTTAATCCTGAAAATATCCTTAAAATCA
ACAAAGAAGAAAAAATGGCAATGTTTGATAACAATATTGGATGTCCCATCTCCCGTACGAAATATAGGGGCCTTTTGGAG
AAGGTTAAATCGATGAAAAGCTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-122)

LytTr DNA-binding domain (LytTR)

(152-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.772

97.571

0.534
  comE/comE1 Streptococcus equinus JB1

44.856

98.381

0.441
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.057

100

0.381
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.057

100

0.381
  comE/comE2 Streptococcus equinus JB1

37.805

99.595

0.377
  comE Streptococcus pneumoniae R6

37.759

97.571

0.368
  comE Streptococcus pneumoniae TIGR4

37.759

97.571

0.368
  comE Streptococcus mitis SK321

37.759

97.571

0.368
  comE Streptococcus mitis NCTC 12261

37.759

97.571

0.368
  comE Streptococcus pneumoniae Rx1

37.759

97.571

0.368
  comE Streptococcus pneumoniae D39

37.759

97.571

0.368
  comE Streptococcus infantis strain Atu-4

36.929

97.571

0.36

Multiple sequence alignment