Detailed information NTG0040889

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SSUD12_RS06415
• Genome accession: NC_017621
• Coordinates: 1287197..1287937 (-)
• Length: 246 a.a.
• NCBI ID: WP_014638212.1
• Uniprot ID: -
• Organism: Streptococcus suis D12
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1282197..1292937

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSUD12_RS06405 (SSUD12_1279)	comB	1284054..1285412 (+)	1359	WP_014638209.1	bacteriocin secretion accessory protein	Regulator
SSUD12_RS11510 (SSUD12_1280)	-	1285514..1285675 (+)	162	WP_014638210.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SSUD12_RS06410 (SSUD12_1281)	-	1285843..1287186 (-)	1344	WP_014638211.1	GHKL domain-containing protein	-
SSUD12_RS06415 (SSUD12_1282)	comE/blpR	1287197..1287937 (-)	741	WP_014638212.1	response regulator transcription factor	Regulator
SSUD12_RS06420 (SSUD12_1283)	-	1288304..1289557 (+)	1254	WP_014637301.1	IS110 family transposase	-
SSUD12_RS06425 (SSUD12_1284)	-	1289686..1290018 (-)	333	WP_014638213.1	LytTR family DNA-binding domain-containing protein	-
SSUD12_RS11890 (SSUD12_1285)	-	1290211..1290597 (+)	387	WP_014638214.1	hypothetical protein	-
SSUD12_RS11895	-	1290539..1292124 (-)	1586	Protein_1216	SAG1250 family conjugative relaxase	-
SSUD12_RS06440 (SSUD12_1288)	-	1292244..1292861 (-)	618	WP_014638217.1	SAP domain-containing protein	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28874.95 Da
• Isoelectric Point: 5.6240

>NTDB_id=40889 SSUD12_RS06415 WP_014638212.1 1287197..1287937(-) (comE/blpR) [Streptococcus suis D12]
MNIFILEDDFFQQTRMENIVRQIVSDKQIGVKHFEVYGKPGQLLEDITERGGHQLFFLDIEIKDDKKKGLDLALEIRRKD
PHAEIVFVTTHSEFMPVSFQYHVSALDFIDKELSEKQFIERIEQSIDYVQNQQGQTLAEDSFIFKNAKTQVQIPFADLLY
IETSYIAHKLVLYSTRERIEFYGELSEIVKQEPRLFQCHRSYVVNPYNISSINRDERLVYLKNGSTCMVSRLKITALKEA
VENLHT

Nucleotide

• Length: 741 bp

>NTDB_id=40889 SSUD12_RS06415 WP_014638212.1 1287197..1287937(-) (comE/blpR) [Streptococcus suis D12]
ATGAATATCTTTATACTTGAAGATGATTTTTTTCAACAAACTCGAATGGAAAATATTGTTCGTCAAATAGTATCTGATAA
ACAAATTGGTGTCAAACATTTTGAAGTTTATGGAAAACCAGGTCAACTTTTAGAAGATATTACTGAAAGAGGAGGACATC
AACTTTTCTTTCTGGATATTGAAATCAAGGATGACAAGAAAAAAGGTTTAGATTTAGCTCTAGAGATTAGGCGAAAAGAT
CCTCATGCTGAAATTGTGTTTGTGACAACTCACTCAGAGTTTATGCCAGTTTCTTTCCAGTATCATGTTTCTGCTCTAGA
CTTTATTGATAAAGAATTATCGGAAAAACAGTTCATTGAGCGCATTGAACAATCAATTGACTATGTTCAAAATCAACAGG
GGCAAACTTTAGCTGAAGATTCATTTATTTTTAAAAACGCTAAGACTCAGGTTCAGATTCCATTTGCTGATTTACTTTAT
ATTGAAACATCATACATTGCCCATAAGCTGGTTCTTTATTCTACTAGAGAAAGGATTGAATTTTATGGTGAGTTATCTGA
AATAGTTAAACAAGAACCAAGATTATTTCAATGTCATCGCTCGTATGTTGTAAATCCCTATAATATATCATCCATCAATC
GAGACGAACGATTGGTTTACCTAAAAAATGGTTCGACATGTATGGTATCAAGGTTAAAGATTACTGCACTCAAAGAAGCA
GTCGAAAACCTTCATACATAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.869	99.187	0.524
comE/comE1	Streptococcus equinus JB1	40.928	96.341	0.394
comE/comE2	Streptococcus equinus JB1	38.115	99.187	0.378
comE/comE2	Streptococcus gordonii strain NCTC7865	37.805	100	0.378
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.805	100	0.378
comE	Streptococcus pneumoniae Rx1	36.437	100	0.366
comE	Streptococcus pneumoniae D39	36.437	100	0.366
comE	Streptococcus pneumoniae R6	36.437	100	0.366
comE	Streptococcus pneumoniae TIGR4	36.437	100	0.366
comE	Streptococcus mitis NCTC 12261	36.437	100	0.366
comE	Streptococcus mitis SK321	36.437	100	0.366