Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   GOM46_RS08290 Genome accession   NZ_CP046525
Coordinates   1702447..1703199 (-) Length   250 a.a.
NCBI ID   WP_235083585.1    Uniprot ID   -
Organism   Streptococcus infantis strain SO     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1697447..1708199
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GOM46_RS08270 (GOM46_08215) - 1698891..1701533 (-) 2643 WP_235083584.1 YhgE/Pip domain-containing protein -
  GOM46_RS08275 (GOM46_08220) - 1701663..1702205 (+) 543 WP_006150545.1 TetR/AcrR family transcriptional regulator -
  GOM46_RS08290 (GOM46_08235) comE 1702447..1703199 (-) 753 WP_235083585.1 competence system response regulator transcription factor ComE Regulator
  GOM46_RS08295 (GOM46_08240) comD 1703196..1704515 (-) 1320 WP_235083586.1 competence system sensor histidine kinase ComD Regulator
  GOM46_RS08305 (GOM46_08250) rlmH 1704800..1705279 (-) 480 WP_235083587.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  GOM46_RS08310 (GOM46_08255) htrA 1705463..1706638 (+) 1176 WP_235083588.1 S1C family serine protease Regulator
  GOM46_RS08315 (GOM46_08260) spo0J 1706695..1707456 (+) 762 WP_235083589.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29893.36 Da        Isoelectric Point: 8.5724

>NTDB_id=405092 GOM46_RS08290 WP_235083585.1 1702447..1703199(-) (comE) [Streptococcus infantis strain SO]
MKVLILEDVIQHQVRLERTLDEISKELNIPISYKTTGKEREFKEYIENDEVNQLYFLDIDIHGVEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIKQSILYTKSMLLENKDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKETQRFYSAHKSFLVNVGNIREIDRKNLEVVFYEEHRCPITRLKVRKL
RDILEKKSKK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=405092 GOM46_RS08290 WP_235083585.1 1702447..1703199(-) (comE) [Streptococcus infantis strain SO]
ATGAAAGTATTAATTTTAGAAGATGTTATTCAACATCAAGTCAGACTAGAAAGAACCTTGGATGAAATTTCAAAGGAATT
AAATATTCCTATTTCTTATAAAACAACAGGTAAAGAACGAGAATTTAAGGAATATATCGAAAATGACGAAGTAAACCAGC
TTTATTTTCTAGATATTGATATTCATGGAGTTGAGAAAAAAGGATTTGAAGTCGCACAGTTTATTCGTCACCACAATCCC
TATGCAATTATCGTATTTATCACTAGTAGATCAGAATTTGCTACCTTAACTTACAAATATCAAGTATCCGCCTTGGATTT
TGTTGATAAAGATATCAATGATGAATTATTTAAGAAACGTATCAAACAGAGTATCTTATATACCAAGAGTATGCTGCTTG
AAAATAAAGATGTTGTGGATTATTTTGACTATAACTACAAGGGGAATGATTTGAAGATCCCCTACCATGATATTTTGTAT
ATTGAAACAACAGGTGTTTCTCATAAGTTACGGATTATTGGTAAGAATTTCGCTAAAGAATTTTATGGAACCATGACGGA
TATCCAAGAAAAAGATAAAGAAACCCAAAGATTTTATTCCGCTCATAAATCATTTCTTGTTAATGTAGGAAATATTAGGG
AAATTGATCGAAAAAATTTAGAAGTGGTTTTTTATGAGGAACATCGCTGCCCGATTACCCGTCTCAAGGTTCGGAAATTA
AGAGATATTCTGGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(32-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus infantis strain Atu-4

98

100

0.98
  comE Streptococcus mitis NCTC 12261

92.8

100

0.928
  comE Streptococcus mitis SK321

92

100

0.92
  comE Streptococcus pneumoniae Rx1

91.2

100

0.912
  comE Streptococcus pneumoniae D39

91.2

100

0.912
  comE Streptococcus pneumoniae R6

91.2

100

0.912
  comE Streptococcus pneumoniae TIGR4

91.2

100

0.912
  comE/comE2 Streptococcus gordonii strain NCTC7865

64.4

100

0.644
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

64.4

100

0.644
  comE/blpR Streptococcus mutans UA159

41.7

98.8

0.412

Multiple sequence alignment