Detailed information NTG0403185

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: GL185_RS07555
• Genome accession: NZ_CP046357
• Coordinates: 1507001..1507753 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 525
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1502001..1512753

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL185_RS07525 (GL185_07660)	spo0J	1502592..1503350 (-)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator
GL185_RS07530 (GL185_07665)	htrA	1503408..1504589 (-)	1182	WP_000681598.1	S1C family serine protease	Regulator
GL185_RS07535 (GL185_07670)	rlmH	1504772..1505251 (+)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
GL185_RS07545 (GL185_07680)	comC/comC2	1505533..1505658 (+)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator
GL185_RS07550 (GL185_07685)	comD/comD2	1505679..1507004 (+)	1326	WP_024477997.1	competence system sensor histidine kinase ComD	Regulator
GL185_RS07555 (GL185_07690)	comE	1507001..1507753 (+)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
GL185_RS07570 (GL185_07705)	-	1507996..1508538 (-)	543	WP_001158269.1	TetR/AcrR family transcriptional regulator	-
GL185_RS11520	-	1508717..1510320 (+)	1604	Protein_1514	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=403185 GL185_RS07555 WP_000866065.1 1507001..1507753(+) (comE) [Streptococcus pneumoniae strain 525]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=403185 GL185_RS07555 WP_000866065.1 1507001..1507753(+) (comE) [Streptococcus pneumoniae strain 525]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATTGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408