Detailed information NTG0389014

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: LPB220_RS10705
• Genome accession: NZ_CP044230
• Coordinates: 2127863..2128621 (-)
• Length: 252 a.a.
• NCBI ID: WP_003009229.1
• Uniprot ID: V8B9D8
• Organism: Streptococcus sp. LPB0220
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2122863..2133621

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LPB220_RS10685 (LPB220_10690)	-	2123317..2124942 (+)	1626	WP_021154160.1	ABC-F family ATP-binding cassette domain-containing protein	-
LPB220_RS10690 (LPB220_10695)	-	2124992..2127559 (+)	2568	WP_150906766.1	YfhO family protein	-
LPB220_RS10705 (LPB220_10710)	comE/comE2	2127863..2128621 (-)	759	WP_003009229.1	response regulator transcription factor	Regulator
LPB220_RS10710 (LPB220_10715)	-	2128618..2129958 (-)	1341	WP_150906768.1	GHKL domain-containing protein	-
LPB220_RS10720 (LPB220_10725)	rlmH	2130415..2130894 (-)	480	WP_003009233.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
LPB220_RS10725 (LPB220_10730)	htrA	2131099..2132280 (+)	1182	WP_023920001.1	S1C family serine protease	Regulator
LPB220_RS10730 (LPB220_10735)	spo0J	2132352..2133113 (+)	762	WP_150906770.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 252 a.a.
• Molecular weight: 29548.05 Da
• Isoelectric Point: 5.4835

>NTDB_id=389014 LPB220_RS10705 WP_003009229.1 2127863..2128621(-) (comE/comE2) [Streptococcus sp. LPB0220]
MKIFLLEDELSQQIRVEKHIAEIAKELEIKLEVISTGKISEFENYIQHSDIHQLYFLDIHIQDNEYCGLEIAQKIREANP
YAIIVFITTKSEFASITYRYKVSALDFIDKNLNEDLFRLKIKECIEYLTTIQIGNDDLTDYFEYDFKDKKIKIPFKDILY
IETVGSAYKLNLVGKNFQKEIAGSLSDVLEKDVEERYFSPHQSFIVNRSMIIGMDKKKKQLLLKEGYSCPISRSNIKRAK
KLIEEQNLEFSA

Nucleotide

• Length: 759 bp

>NTDB_id=389014 LPB220_RS10705 WP_003009229.1 2127863..2128621(-) (comE/comE2) [Streptococcus sp. LPB0220]
ATGAAGATTTTTTTATTAGAAGATGAGCTCTCTCAACAGATACGGGTAGAAAAACATATTGCAGAAATTGCTAAGGAATT
AGAAATTAAACTTGAAGTGATTTCTACCGGTAAAATTTCGGAATTTGAAAATTATATCCAGCATTCGGATATCCACCAAT
TATATTTTCTAGATATTCATATCCAAGACAATGAGTATTGTGGGCTGGAAATTGCTCAAAAAATACGAGAAGCAAATCCT
TATGCCATTATTGTTTTTATTACTACAAAATCAGAATTCGCTTCGATTACCTATCGTTATAAAGTATCTGCCTTAGATTT
TATTGATAAAAATTTGAATGAAGATTTATTTAGATTAAAAATTAAGGAGTGTATTGAGTACCTAACGACTATTCAAATTG
GAAATGATGATTTGACAGATTATTTTGAGTATGACTTTAAGGATAAAAAGATAAAAATTCCATTTAAGGATATTCTTTAT
ATTGAAACTGTTGGTTCGGCTTATAAATTAAACTTAGTTGGGAAAAATTTTCAAAAAGAAATTGCGGGAAGTTTATCAGA
TGTCTTGGAGAAAGATGTGGAGGAGAGATATTTCAGTCCCCATCAATCTTTTATCGTGAATAGAAGTATGATCATTGGAA
TGGATAAGAAAAAGAAACAGCTACTGTTGAAAGAAGGCTATTCTTGTCCAATCTCAAGAAGCAATATCAAACGTGCCAAA
AAATTAATTGAAGAGCAAAATTTAGAATTTAGTGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (29-120)

• LytTr DNA-binding domain (LytTR) (149-243)

3D structure

• AlphaFold DB: V8B9D8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	49.194	98.413	0.484
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	49.194	98.413	0.484
comE	Streptococcus pneumoniae Rx1	47.177	98.413	0.464
comE	Streptococcus pneumoniae D39	47.177	98.413	0.464
comE	Streptococcus pneumoniae R6	47.177	98.413	0.464
comE	Streptococcus pneumoniae TIGR4	47.177	98.413	0.464
comE	Streptococcus mitis NCTC 12261	47.177	98.413	0.464
comE	Streptococcus mitis SK321	47.177	98.413	0.464
comE	Streptococcus infantis strain Atu-4	45.968	98.413	0.452
comE/blpR	Streptococcus mutans UA159	38.866	98.016	0.381