Detailed information NTG0389015

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: LPB220_RS10725
• Genome accession: NZ_CP044230
• Coordinates: 2131099..2132280 (+)
• Length: 393 a.a.
• NCBI ID: WP_023920001.1
• Uniprot ID: V8B9A7
• Organism: Streptococcus sp. LPB0220
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2126099..2137280

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LPB220_RS10705 (LPB220_10710)	comE/comE2	2127863..2128621 (-)	759	WP_003009229.1	response regulator transcription factor	Regulator
LPB220_RS10710 (LPB220_10715)	-	2128618..2129958 (-)	1341	WP_150906768.1	GHKL domain-containing protein	-
LPB220_RS10720 (LPB220_10725)	rlmH	2130415..2130894 (-)	480	WP_003009233.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
LPB220_RS10725 (LPB220_10730)	htrA	2131099..2132280 (+)	1182	WP_023920001.1	S1C family serine protease	Regulator
LPB220_RS10730 (LPB220_10735)	spo0J	2132352..2133113 (+)	762	WP_150906770.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41720.77 Da
• Isoelectric Point: 5.4734

>NTDB_id=389015 LPB220_RS10725 WP_023920001.1 2131099..2132280(+) (htrA) [Streptococcus sp. LPB0220]
MKSSSNLLKKLGNITLIFVVGFLGGILGTFLTLQTSHSSTSNTESKQVHSTTVKTAYKNTTSTSEAVDKVKNAVVSVITY
SDSSNQGLFEKEENSDSQISSEGSGVIYKKEGKYAYLVTNTHVINGAKKVDILLADGNKVPGEVVGSDVYSDIAVVRISA
DKAKAVAEFGDSNQLTVGETAIAIGSPLGTDYANSVTQGIISSQGRNVNLKADNGQNISTRALQTDAAINPGNSGGPLIN
IQGQVIGITSSKISNNGQTSVEGMGFAIPANDVVNIIKQLEEKGKVVRPALGIQMMDLSNLSTSDLSQLKLPEKISGGVL
VRSTLENMPASDKLQRYDVITKIDDTDIESTADLQSALYSHQINDTIKVTFYRDGKQQTTSIKLTKSTEDLSD

Nucleotide

• Length: 1182 bp

>NTDB_id=389015 LPB220_RS10725 WP_023920001.1 2131099..2132280(+) (htrA) [Streptococcus sp. LPB0220]
ATGAAATCTTCATCTAATTTACTAAAAAAACTTGGAAACATAACCCTCATTTTCGTTGTAGGTTTTCTAGGTGGGATTCT
TGGAACCTTTTTAACCTTACAAACCTCTCATTCTTCTACTTCAAATACTGAAAGTAAGCAAGTCCACTCAACCACTGTTA
AAACAGCTTATAAAAATACAACCTCAACTAGTGAGGCCGTAGATAAGGTGAAAAATGCTGTAGTTTCTGTGATTACTTAT
TCTGATTCTTCGAATCAAGGGTTATTTGAAAAAGAAGAAAACTCTGACTCACAAATTTCTAGTGAAGGTTCTGGGGTCAT
TTATAAAAAAGAAGGAAAATATGCCTACCTTGTTACCAACACCCATGTAATCAATGGTGCTAAAAAAGTAGATATTCTTT
TAGCAGATGGCAATAAAGTCCCCGGAGAAGTAGTTGGGTCAGATGTCTATTCTGATATTGCAGTCGTTCGCATTAGTGCG
GATAAAGCAAAGGCAGTAGCTGAATTCGGAGATTCAAACCAATTAACAGTCGGTGAGACTGCAATTGCAATTGGTAGCCC
TCTTGGAACTGATTATGCGAATTCTGTTACTCAAGGGATCATTTCTAGCCAAGGTCGCAATGTGAATTTGAAAGCTGATA
ATGGACAAAATATCTCTACACGCGCCTTACAAACAGACGCAGCCATCAACCCAGGGAACTCTGGAGGGCCATTAATCAAT
ATTCAAGGACAAGTCATTGGGATTACCTCAAGTAAAATTTCAAATAATGGACAAACTTCAGTAGAAGGAATGGGATTTGC
TATTCCTGCAAATGATGTTGTCAATATTATCAAACAGCTAGAAGAAAAAGGAAAAGTAGTTCGACCAGCTCTTGGAATCC
AAATGATGGATTTATCCAACCTTTCAACTTCTGATTTAAGCCAATTAAAACTTCCTGAAAAAATCTCTGGAGGAGTACTG
GTTCGTTCAACACTTGAAAATATGCCTGCTTCAGATAAATTGCAACGTTATGATGTCATCACAAAGATCGATGATACAGA
TATCGAGTCAACTGCAGATTTACAATCAGCCCTCTATTCTCACCAAATCAATGATACGATCAAGGTCACATTCTATCGTG
ATGGAAAACAACAAACAACTTCTATCAAGTTGACAAAATCAACTGAGGATCTGAGCGATTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: V8B9A7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	68.09	100	0.69
htrA	Streptococcus mitis NCTC 12261	63.359	100	0.634
htrA	Streptococcus pneumoniae Rx1	63.359	100	0.634
htrA	Streptococcus pneumoniae D39	63.359	100	0.634
htrA	Streptococcus pneumoniae R6	63.359	100	0.634
htrA	Streptococcus pneumoniae TIGR4	63.359	100	0.634
htrA	Streptococcus mutans UA159	54.026	97.964	0.529