Detailed information NTG0388966

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: LPB220_RS01370
• Genome accession: NZ_CP044230
• Coordinates: 235783..236517 (+)
• Length: 244 a.a.
• NCBI ID: WP_150905164.1
• Uniprot ID: A0A5J6LKK0
• Organism: Streptococcus sp. LPB0220
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 230783..241517

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LPB220_RS01345 (LPB220_01345)	-	231017..231859 (+)	843	WP_003019182.1	PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC	-
LPB220_RS01350 (LPB220_01350)	-	231843..232697 (+)	855	WP_173018936.1	PTS system mannose/fructose/sorbose family transporter subunit IID	-
LPB220_RS01355 (LPB220_01355)	-	232798..233091 (+)	294	WP_003004348.1	hypothetical protein	-
LPB220_RS01360 (LPB220_01360)	groES	233221..233502 (+)	282	WP_024055367.1	co-chaperone GroES	-
LPB220_RS01365 (LPB220_01365)	groL	233524..235149 (+)	1626	WP_150905162.1	chaperonin GroEL	-
LPB220_RS01370 (LPB220_01370)	comE/blpR	235783..236517 (+)	735	WP_150905164.1	response regulator transcription factor	Regulator
LPB220_RS01375 (LPB220_01375)	-	236531..237835 (+)	1305	WP_150905166.1	sensor histidine kinase	-
LPB220_RS01385 (LPB220_01385)	-	238125..238805 (+)	681	WP_061591468.1	ABC transporter ATP-binding protein	-
LPB220_RS01390 (LPB220_01390)	-	238802..239509 (+)	708	WP_150905168.1	ABC transporter	-
LPB220_RS01400 (LPB220_01400)	-	239707..240237 (-)	531	WP_150905170.1	hypothetical protein	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28154.38 Da
• Isoelectric Point: 6.6979

>NTDB_id=388966 LPB220_RS01370 WP_150905164.1 235783..236517(+) (comE/blpR) [Streptococcus sp. LPB0220]
MLKIFVLEDEWIQQSRIESVLQDLIHQKSLQCKAPEVFGKSSQLLDAITERGAHHLFFLDIEIKGEEKKGLEIAKEIRKK
DPHATIVFVTTHSEFMPITFQYKVAALDFIDKTLGEEEFRERISSAIDYTLEQAGTTIAQDAFTFESAMARVQVPFNKIL
YVETSPTIHKVILHTKDERLEFYASIADIEKADPRLYRCHRSFVVNPQNITKIDKEAKKAFFENGDNCLISRTKYRGLLE
ALKK

Nucleotide

• Length: 735 bp

>NTDB_id=388966 LPB220_RS01370 WP_150905164.1 235783..236517(+) (comE/blpR) [Streptococcus sp. LPB0220]
TTGTTGAAGATTTTTGTGTTAGAAGATGAGTGGATCCAGCAATCACGAATCGAATCGGTCTTGCAGGATCTCATCCATCA
AAAATCCCTGCAATGCAAAGCACCAGAAGTGTTTGGGAAATCAAGCCAGTTGCTGGATGCTATCACAGAGAGAGGCGCTC
ATCACCTATTCTTTTTAGATATCGAGATTAAAGGTGAGGAGAAAAAAGGTCTGGAGATTGCAAAAGAGATTCGTAAGAAA
GACCCCCATGCGACCATTGTCTTTGTCACCACTCACTCTGAATTCATGCCCATTACCTTTCAGTACAAAGTAGCCGCCTT
GGATTTTATCGATAAAACGCTGGGTGAGGAAGAGTTCAGAGAGAGAATCAGCTCAGCCATCGATTATACCTTGGAGCAAG
CTGGGACCACGATTGCGCAAGATGCTTTTACATTTGAGAGTGCGATGGCGCGTGTACAAGTTCCCTTTAATAAGATTTTG
TATGTTGAAACTTCTCCAACCATTCACAAGGTTATTTTACACACCAAGGATGAGCGATTAGAATTTTACGCTAGTATTGC
CGATATCGAAAAAGCAGATCCCCGCTTGTATCGGTGCCACCGCTCCTTTGTGGTGAATCCACAAAATATTACGAAGATTG
ATAAGGAAGCCAAGAAAGCTTTTTTTGAAAATGGGGACAATTGCTTGATCTCACGGACCAAGTATAGAGGCTTACTGGAA
GCTTTGAAAAAATAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A5J6LKK0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.649	97.951	0.545
comE/comE1	Streptococcus equinus JB1	46.091	99.59	0.459
comE/comE2	Streptococcus gordonii strain NCTC7865	39.837	100	0.402
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.837	100	0.402
comE/comE2	Streptococcus equinus JB1	38.462	100	0.389
comE	Streptococcus pneumoniae TIGR4	36.4	100	0.373
comE	Streptococcus mitis NCTC 12261	36.4	100	0.373
comE	Streptococcus mitis SK321	36.4	100	0.373
comE	Streptococcus infantis strain Atu-4	36.4	100	0.373
comE	Streptococcus pneumoniae Rx1	36.4	100	0.373
comE	Streptococcus pneumoniae D39	36.4	100	0.373
comE	Streptococcus pneumoniae R6	36.4	100	0.373