Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   HHM65_RS02995 Genome accession   NZ_CP051624
Coordinates   542063..542812 (+) Length   249 a.a.
NCBI ID   WP_170078153.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 537063..547812
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HHM65_RS02955 (HHM65_02960) - 537249..537521 (+) 273 WP_003058867.1 hypothetical protein -
  HHM65_RS02960 (HHM65_02965) - 537518..537745 (+) 228 WP_003058873.1 phage holin -
  HHM65_RS02965 (HHM65_02970) - 537867..538619 (+) 753 WP_115261972.1 CHAP domain-containing protein -
  HHM65_RS02970 (HHM65_02975) - 538764..539015 (-) 252 WP_048327312.1 hypothetical protein -
  HHM65_RS02975 (HHM65_02980) - 539157..539303 (-) 147 WP_164406938.1 hypothetical protein -
  HHM65_RS02980 (HHM65_02985) - 539457..539666 (+) 210 WP_048327315.1 helix-turn-helix transcriptional regulator -
  HHM65_RS02985 (HHM65_02990) prx 540142..540324 (+) 183 WP_170078152.1 Paratox Regulator
  HHM65_RS02990 (HHM65_02995) - 540709..541815 (-) 1107 Protein_535 IS3 family transposase -
  HHM65_RS02995 (HHM65_03000) comE/blpR 542063..542812 (+) 750 WP_170078153.1 response regulator transcription factor Regulator
  HHM65_RS03000 (HHM65_03005) - 542813..544147 (+) 1335 WP_015057381.1 GHKL domain-containing protein -
  HHM65_RS03005 (HHM65_03010) - 544295..544420 (-) 126 WP_011017462.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  HHM65_RS03010 (HHM65_03015) - 544497..545861 (-) 1365 WP_015057382.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29084.40 Da        Isoelectric Point: 5.6011

>NTDB_id=385898 HHM65_RS02995 WP_170078153.1 542063..542812(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNKD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAISYVQDNQGKTLAEDSFVFTNVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHCSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=385898 HHM65_RS02995 WP_170078153.1 542063..542812(+) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAAAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAAGTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATTGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-119)

LytTr DNA-binding domain (LytTR)

(150-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.098

97.992

0.53
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.873

100

0.414
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.873

100

0.414
  comE/comE2 Streptococcus equinus JB1

40.984

97.992

0.402
  comE/comE1 Streptococcus equinus JB1

42.017

95.582

0.402
  comE Streptococcus mitis SK321

38.8

100

0.39
  comE Streptococcus mitis NCTC 12261

38.8

100

0.39
  comE Streptococcus pneumoniae TIGR4

38.4

100

0.386
  comE Streptococcus pneumoniae Rx1

38.4

100

0.386
  comE Streptococcus pneumoniae D39

38.4

100

0.386
  comE Streptococcus pneumoniae R6

38.4

100

0.386
  comE Streptococcus infantis strain Atu-4

38.095

100

0.386

Multiple sequence alignment