Detailed information NTG0367618

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: FEE40_RS02450
• Genome accession: NZ_CP040852
• Coordinates: 495914..496651 (-)
• Length: 245 a.a.
• NCBI ID: WP_004049924.1
• Uniprot ID: A0AAE6WG22
• Organism: Ligilactobacillus murinus strain V10
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 490914..501651

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FEE40_RS02425 (FEE40_02420)	-	491962..492297 (-)	336	Protein_480	ABC transporter ATP-binding protein	-
FEE40_RS02430 (FEE40_02425)	-	492326..493261 (-)	936	WP_112286402.1	IS3 family transposase	-
FEE40_RS02435 (FEE40_02430)	-	493186..493713 (-)	528	WP_004048179.1	helix-turn-helix domain-containing protein	-
FEE40_RS02440 (FEE40_02435)	-	493766..494050 (-)	285	Protein_483	ATP-binding cassette domain-containing protein	-
FEE40_RS02445 (FEE40_02440)	-	494574..495899 (-)	1326	WP_004049925.1	GHKL domain-containing protein	-
FEE40_RS02450 (FEE40_02445)	comE/blpR	495914..496651 (-)	738	WP_004049924.1	LytTR family DNA-binding domain-containing protein	Regulator
FEE40_RS02455 (FEE40_02450)	-	496923..497810 (-)	888	WP_004049921.1	GRP family sugar transporter	-
FEE40_RS02460 (FEE40_02455)	rbsD	497830..498225 (-)	396	WP_056959126.1	D-ribose pyranase	-
FEE40_RS02465 (FEE40_02460)	rbsK	498244..499149 (-)	906	WP_004049918.1	ribokinase	-
FEE40_RS02470 (FEE40_02465)	-	499256..500248 (-)	993	WP_163587506.1	LacI family DNA-binding transcriptional regulator	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28239.61 Da
• Isoelectric Point: 5.9838

>NTDB_id=367618 FEE40_RS02450 WP_004049924.1 495914..496651(-) (comE/blpR) [Ligilactobacillus murinus strain V10]
MINIFVLEDEILQQSRIETAILKILNEEQIKCRVFDVFGSSSQLLEAIEERGGHQLFFLDIEIKDEEKKGLEIAKEIRKK
DPAATIVFVTTHSEFMPLTFKFKVSALDFIDKALGEQYFYERIKSAIDYTLASAGETLSQESFHLETSLSQIQVPLKKIL
YFETSPTVHKVILHTIDERIEFYATISEIEKKDSRLYRSHKSFVVNPANIERLDKVNKIIYFPNGDSCLVARTKLKGLSE
RITLL

Nucleotide

• Length: 738 bp

>NTDB_id=367618 FEE40_RS02450 WP_004049924.1 495914..496651(-) (comE/blpR) [Ligilactobacillus murinus strain V10]
ATGATCAATATTTTTGTACTTGAAGATGAGATACTTCAACAGTCTCGCATTGAAACGGCCATTCTAAAAATTTTAAACGA
AGAACAGATAAAGTGTAGAGTTTTTGATGTTTTTGGAAGCTCTTCTCAATTGTTAGAAGCTATTGAGGAGAGAGGGGGGC
ACCAGTTATTTTTCCTAGATATTGAAATTAAGGACGAGGAGAAAAAAGGACTGGAGATCGCTAAGGAGATCCGAAAAAAA
GATCCCGCTGCGACTATCGTTTTTGTGACGACGCATTCGGAATTTATGCCACTAACATTTAAATTTAAAGTTAGTGCTCT
TGATTTTATCGATAAAGCTTTAGGAGAGCAATACTTCTATGAGCGTATTAAATCTGCTATTGACTACACACTAGCTAGTG
CTGGAGAAACGCTGTCTCAAGAATCATTTCATTTAGAAACGTCACTATCTCAAATACAAGTGCCTTTAAAAAAAATCCTG
TATTTTGAAACATCCCCGACTGTACATAAGGTTATTTTGCATACGATCGATGAACGAATTGAATTTTATGCAACGATCTC
TGAGATCGAAAAAAAAGACAGCCGATTATATAGAAGCCATAAGTCATTTGTAGTAAATCCTGCTAACATTGAGCGTCTGG
ATAAGGTCAATAAGATCATTTATTTTCCAAATGGAGATTCTTGTTTAGTAGCACGAACAAAACTTAAAGGATTAAGTGAA
AGGATTACATTATTGTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.23	97.551	0.539
comE/comE1	Streptococcus equinus JB1	47.521	98.776	0.469
comE/comE2	Streptococcus equinus JB1	41.736	98.776	0.412
comE/comE2	Streptococcus gordonii strain NCTC7865	39.754	99.592	0.396
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.754	99.592	0.396
comE	Streptococcus pneumoniae R6	37.037	99.184	0.367
comE	Streptococcus pneumoniae TIGR4	37.037	99.184	0.367
comE	Streptococcus mitis NCTC 12261	37.037	99.184	0.367
comE	Streptococcus mitis SK321	37.037	99.184	0.367
comE	Streptococcus pneumoniae Rx1	37.037	99.184	0.367
comE	Streptococcus pneumoniae D39	37.037	99.184	0.367
comE	Streptococcus infantis strain Atu-4	36.626	99.184	0.363