Detailed information NTG0367254

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: FDP16_RS11685
• Genome accession: NZ_CP040798
• Coordinates: 2337136..2337900 (-)
• Length: 254 a.a.
• NCBI ID: WP_002899424.1
• Uniprot ID: A0A0B7GUD9
• Organism: Streptococcus sanguinis strain CGMH058
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2332136..2342900

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FDP16_RS11665 (FDP16_12140)	-	2332546..2334168 (+)	1623	WP_002899531.1	ATP-binding cassette domain-containing protein	-
FDP16_RS11670 (FDP16_12145)	-	2334244..2336829 (+)	2586	WP_176799743.1	YfhO family protein	-
FDP16_RS11685 (FDP16_12160)	comE	2337136..2337900 (-)	765	WP_002899424.1	competence system response regulator transcription factor ComE	Regulator
FDP16_RS11690 (FDP16_12165)	comD	2337906..2339240 (-)	1335	WP_176799744.1	competence system sensor histidine kinase ComD	-
FDP16_RS11695 (FDP16_12170)	-	2339268..2339375 (-)	108	WP_176799745.1	competence protein	-
FDP16_RS11705 (FDP16_12180)	rlmH	2339672..2340151 (-)	480	WP_002928597.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FDP16_RS11710 (FDP16_12185)	htrA	2340355..2341527 (+)	1173	WP_176799746.1	S1C family serine protease	Regulator
FDP16_RS11715 (FDP16_12190)	spo0J	2341591..2342352 (+)	762	WP_176799747.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 254 a.a.
• Molecular weight: 29851.13 Da
• Isoelectric Point: 8.0162

>NTDB_id=367254 FDP16_RS11685 WP_002899424.1 2337136..2337900(-) (comE) [Streptococcus sanguinis strain CGMH058]
MKVLVLEDTVSHQVRMETTLAEIAEELGIDIQVQVTGKIKEFKKYIENGDVNQLYFLDIDIKGEETKGLEVAQFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINNDAFKNRIKDSILYTKSTLIENTNMVDYFEYSYRGNDVRMPYNDILY
IETTGSSHKLRIVGKNFLKEFYGTITDIQEKDQQSKRFFSPHKSYLVNIGNIVDYDKKNREIIFYENHRCPVTRLRVKYL
KDIFENKGKRVDKA

Nucleotide

• Length: 765 bp

>NTDB_id=367254 FDP16_RS11685 WP_002899424.1 2337136..2337900(-) (comE) [Streptococcus sanguinis strain CGMH058]
ATGAAAGTGTTAGTTTTAGAGGATACTGTATCTCATCAAGTCAGGATGGAAACGACATTAGCAGAAATTGCTGAGGAACT
TGGAATTGACATCCAGGTTCAGGTTACAGGAAAAATCAAAGAATTCAAAAAATATATTGAAAATGGAGACGTTAACCAGC
TTTATTTTTTGGATATTGATATTAAGGGGGAGGAAACAAAAGGGCTGGAAGTAGCTCAATTTATTCGTCATCATAATCCT
TATGCCATTATAGTTTTTGTAACCTCAAAATCTGAATTTGCTACTATGACTTTTAAATATAAAGTATCAGCACTTGATTT
TATCGATAAAGATATCAACAATGATGCTTTCAAAAATAGAATCAAAGACAGTATTCTTTACACTAAGAGTACACTAATTG
AAAATACCAATATGGTAGATTATTTTGAATATAGTTATCGTGGCAATGATGTTCGAATGCCTTATAACGATATTTTGTAT
ATCGAAACGACAGGGAGCTCCCATAAACTTCGGATTGTTGGTAAAAATTTTCTCAAGGAGTTTTATGGAACGATAACAGA
TATTCAAGAAAAAGATCAGCAATCTAAACGATTTTTTTCACCACATAAATCTTATCTGGTTAATATTGGCAACATTGTTG
ATTATGACAAGAAAAATCGAGAAATTATTTTTTACGAAAATCATCGCTGTCCGGTCACTCGTTTAAGAGTGAAATATCTG
AAAGATATTTTCGAAAATAAAGGGAAAAGAGTTGACAAAGCTTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-244)

• Response regulator receiver domain (Response_reg) (4-121)

3D structure

• AlphaFold DB: A0A0B7GUD9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus infantis strain Atu-4	68.4	98.425	0.673
comE/comE2	Streptococcus gordonii strain NCTC7865	68.4	98.425	0.673
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	68.4	98.425	0.673
comE	Streptococcus mitis NCTC 12261	68	98.425	0.669
comE	Streptococcus mitis SK321	67.2	98.425	0.661
comE	Streptococcus pneumoniae Rx1	66.8	98.425	0.657
comE	Streptococcus pneumoniae D39	66.8	98.425	0.657
comE	Streptococcus pneumoniae R6	66.8	98.425	0.657
comE	Streptococcus pneumoniae TIGR4	66.8	98.425	0.657
comE/blpR	Streptococcus mutans UA159	38.8	98.425	0.382