Detailed information NTG0367255

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: FDP16_RS11710
• Genome accession: NZ_CP040798
• Coordinates: 2340355..2341527 (+)
• Length: 390 a.a.
• NCBI ID: WP_176799746.1
• Uniprot ID: A0A7H8V4E5
• Organism: Streptococcus sanguinis strain CGMH058
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2335355..2346527

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FDP16_RS11685 (FDP16_12160)	comE	2337136..2337900 (-)	765	WP_002899424.1	competence system response regulator transcription factor ComE	Regulator
FDP16_RS11690 (FDP16_12165)	comD	2337906..2339240 (-)	1335	WP_176799744.1	competence system sensor histidine kinase ComD	-
FDP16_RS11695 (FDP16_12170)	-	2339268..2339375 (-)	108	WP_176799745.1	competence protein	-
FDP16_RS11705 (FDP16_12180)	rlmH	2339672..2340151 (-)	480	WP_002928597.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FDP16_RS11710 (FDP16_12185)	htrA	2340355..2341527 (+)	1173	WP_176799746.1	S1C family serine protease	Regulator
FDP16_RS11715 (FDP16_12190)	spo0J	2341591..2342352 (+)	762	WP_176799747.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 390 a.a.
• Molecular weight: 40850.67 Da
• Isoelectric Point: 4.6743

>NTDB_id=367255 FDP16_RS11710 WP_176799746.1 2340355..2341527(+) (htrA) [Streptococcus sanguinis strain CGMH058]
MKNSSNAIKKALLLFAVLIVGFIGGSLGNYVTTLLTSRVKMNGNSTTSVTTSYKNSTDISEAVKKVQNAVVSVITYAESS
SSVINDESSNDESQISSEGSGVIYKKDGKSAYLVTNTHVLNGSTNVDILLADGNKVPGEVVGSDVFSDISVVKISSEKVT
DVAEFGDSGSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSENGENISTTALQTDAAINPGNSGGPLINIQGQ
VIGITSSKISTNGQTSVEGMGFAIPSDDVVNIINQLEKNGTVTRPALGIQMMDLSNLTTSDFSKLNLPTSVKSGILVRSV
QQGMPADGKLQKNDVITKVDNTDVESTSDLQSALYKHSIGDEVEITYYRDGKSQTVKIKLTKSTKELSPN

Nucleotide

• Length: 1173 bp

>NTDB_id=367255 FDP16_RS11710 WP_176799746.1 2340355..2341527(+) (htrA) [Streptococcus sanguinis strain CGMH058]
ATGAAAAACTCTTCAAATGCCATCAAAAAGGCTTTATTGCTTTTTGCAGTATTAATTGTAGGTTTTATCGGCGGAAGTTT
AGGAAATTATGTTACTACATTACTAACTTCACGCGTAAAAATGAATGGAAATTCAACAACTAGTGTAACTACTTCATATA
AAAACTCTACAGACATTTCAGAAGCTGTGAAAAAGGTTCAAAATGCTGTTGTTTCAGTAATTACTTATGCTGAATCTTCC
AGCAGCGTTATCAATGATGAATCTTCCAACGATGAATCACAAATCTCCAGTGAAGGTTCTGGCGTAATTTATAAAAAAGA
CGGAAAATCAGCCTATCTGGTAACCAACACCCACGTTCTGAACGGATCAACCAATGTAGATATCTTGCTAGCTGATGGAA
ACAAGGTTCCAGGTGAAGTAGTTGGATCAGATGTTTTTTCAGATATCTCTGTCGTTAAAATTAGCTCTGAAAAAGTAACT
GATGTCGCAGAATTTGGAGATTCTGGTTCTCTGACAGTTGGTGAAACAGCAATCGCCATCGGAAGCCCTCTTGGAACAGA
ATACGCTAACTCAGTAACACAAGGAATTATTTCTAGTTTAGGCAGAAACGTTACCTTACAATCTGAAAATGGTGAAAATA
TTTCAACAACTGCACTGCAAACAGATGCTGCAATTAATCCTGGTAACTCTGGCGGCCCGTTGATTAACATCCAAGGACAA
GTTATTGGGATTACTTCAAGTAAAATTTCAACAAATGGCCAAACCTCTGTTGAAGGGATGGGATTTGCGATTCCATCTGA
TGATGTCGTAAATATTATCAATCAACTTGAGAAAAATGGAACAGTCACACGTCCTGCTTTAGGAATTCAAATGATGGATT
TATCTAATCTGACAACTTCTGATTTTTCTAAATTAAATCTTCCTACTTCAGTGAAATCAGGTATTCTTGTTCGCTCTGTT
CAGCAAGGGATGCCTGCTGATGGCAAACTTCAAAAAAATGATGTCATTACAAAAGTAGATAACACAGATGTGGAATCCAC
TAGTGACCTTCAGTCAGCTCTCTACAAGCATAGCATTGGAGATGAGGTAGAGATTACTTATTATCGAGATGGTAAATCTC
AAACAGTCAAAATCAAACTCACTAAATCAACAAAAGAGCTAAGCCCAAATTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (285-380)

• Trypsin-like peptidase domain (Trypsin_2) (99-244)

• Peptidase family M50 (Peptidase_M50) (231-385)

3D structure

• AlphaFold DB: A0A7H8V4E5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	66.835	100	0.677
htrA	Streptococcus mitis NCTC 12261	64.194	100	0.644
htrA	Streptococcus pneumoniae Rx1	64.194	100	0.644
htrA	Streptococcus pneumoniae D39	64.194	100	0.644
htrA	Streptococcus pneumoniae R6	64.194	100	0.644
htrA	Streptococcus pneumoniae TIGR4	64.194	100	0.644
htrA	Streptococcus mutans UA159	54.177	100	0.549