Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   ETT49_RS00660 Genome accession   NZ_CP035450
Coordinates   101945..102883 (+) Length   312 a.a.
NCBI ID   WP_002993471.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm93.4     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 96945..107883
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT49_RS00650 (ETT49_00650) rpoC 97694..101335 (+) 3642 WP_030126920.1 DNA-directed RNA polymerase subunit beta' -
  ETT49_RS00655 (ETT49_00655) - 101487..101852 (+) 366 WP_002986560.1 DUF1033 family protein -
  ETT49_RS00660 (ETT49_00660) comYA 101945..102883 (+) 939 WP_002993471.1 competence type IV pilus ATPase ComGA Machinery gene
  ETT49_RS00665 (ETT49_00665) comYB 102819..103853 (+) 1035 WP_225793059.1 competence type IV pilus assembly protein ComGB Machinery gene
  ETT49_RS00670 (ETT49_00670) comYC 103855..104181 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  ETT49_RS00675 (ETT49_00675) comGD 104156..104584 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  ETT49_RS00680 (ETT49_00680) comGE 104541..104825 (+) 285 WP_265415267.1 competence type IV pilus minor pilin ComGE -
  ETT49_RS00685 (ETT49_00685) comYF 104818..105252 (+) 435 WP_020833199.1 competence type IV pilus minor pilin ComGF Machinery gene
  ETT49_RS00690 (ETT49_00690) comGG 105236..105562 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  ETT49_RS00695 (ETT49_00695) comYH 105660..106613 (+) 954 WP_136269477.1 class I SAM-dependent methyltransferase Machinery gene
  ETT49_RS00700 (ETT49_00700) - 106672..107868 (+) 1197 WP_002986533.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35032.27 Da        Isoelectric Point: 8.5799

>NTDB_id=342218 ETT49_RS00660 WP_002993471.1 101945..102883(+) (comYA) [Streptococcus pyogenes strain emm93.4]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISSYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=342218 ETT49_RS00660 WP_002993471.1 101945..102883(+) (comYA) [Streptococcus pyogenes strain emm93.4]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTTAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAAGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAGTTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.736

99.679

0.615
  comYA Streptococcus mutans UA140

61.736

99.679

0.615
  comYA Streptococcus gordonii str. Challis substr. CH1

60.772

99.679

0.606
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.645

99.359

0.603
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.807

99.679

0.596
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae D39

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae R6

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

59.164

99.679

0.59
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

39.655

92.949

0.369

Multiple sequence alignment