Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   ETT71_RS02425 Genome accession   NZ_CP035428
Coordinates   435096..435845 (+) Length   249 a.a.
NCBI ID   WP_030126108.1    Uniprot ID   A0A223M029
Organism   Streptococcus pyogenes strain emmSTG866.1     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 430096..440845
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT71_RS09300 - 430232..430450 (+) 219 WP_072135532.1 LytTR family transcriptional regulator DNA-binding domain-containing protein -
  ETT71_RS09305 - 430647..432253 (-) 1607 Protein_415 ABC transporter transmembrane domain-containing protein -
  ETT71_RS02405 (ETT71_02405) - 432551..432775 (+) 225 WP_002994580.1 Blp family class II bacteriocin -
  ETT71_RS09155 - 432753..432929 (+) 177 WP_002994581.1 hypothetical protein -
  ETT71_RS09485 (ETT71_02410) - 433224..433535 (+) 312 WP_225793061.1 CPBP family intramembrane glutamic endopeptidase -
  ETT71_RS09310 - 433620..433748 (+) 129 WP_002994583.1 hypothetical protein -
  ETT71_RS02415 (ETT71_02415) - 434146..434368 (+) 223 Protein_420 Blp family class II bacteriocin -
  ETT71_RS02420 (ETT71_02420) - 434368..434862 (+) 495 Protein_421 transposase -
  ETT71_RS02425 (ETT71_02425) comE/blpR 435096..435845 (+) 750 WP_030126108.1 response regulator transcription factor Regulator
  ETT71_RS02430 (ETT71_02430) - 435846..437180 (+) 1335 WP_063631787.1 sensor histidine kinase -
  ETT71_RS02435 (ETT71_02435) - 437329..437454 (-) 126 WP_011017462.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  ETT71_RS02440 (ETT71_02440) - 437531..438895 (-) 1365 WP_136046694.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29141.44 Da        Isoelectric Point: 5.8302

>NTDB_id=341052 ETT71_RS02425 WP_030126108.1 435096..435845(+) (comE/blpR) [Streptococcus pyogenes strain emmSTG866.1]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNKD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFTNVKSQIQVSFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=341052 ETT71_RS02425 WP_030126108.1 435096..435845(+) (comE/blpR) [Streptococcus pyogenes strain emmSTG866.1]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAAAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTACTAATGTAAAGTCCCAGATACAAGTCTCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGTCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTCAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(150-239)

Response regulator receiver domain (Response_reg)

(3-119)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A223M029

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.098

97.992

0.53
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.476

100

0.41
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.476

100

0.41
  comE/comE1 Streptococcus equinus JB1

42.437

95.582

0.406
  comE/comE2 Streptococcus equinus JB1

40.574

97.992

0.398
  comE Streptococcus mitis NCTC 12261

38.4

100

0.386
  comE Streptococcus mitis SK321

38.4

100

0.386
  comE Streptococcus pneumoniae TIGR4

38

100

0.382
  comE Streptococcus pneumoniae Rx1

38

100

0.382
  comE Streptococcus pneumoniae D39

38

100

0.382
  comE Streptococcus pneumoniae R6

38

100

0.382
  comE Streptococcus infantis strain Atu-4

37.903

99.598

0.378

Multiple sequence alignment