Detailed information NTG0337097

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH39_RS10180
• Genome accession: NZ_CP035241
• Coordinates: 1996242..1996994 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901948
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1991242..2001994

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH39_RS10380 (EQH39_10670)	-	1993676..1995329 (-)	1654	Protein_1979	YhgE/Pip family protein	-
EQH39_RS10165 (EQH39_10675)	-	1995457..1995999 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH39_RS10180 (EQH39_10690)	comE	1996242..1996994 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH39_RS10185 (EQH39_10695)	comD/comD1	1996991..1998316 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
EQH39_RS10190 (EQH39_10700)	comC/comC1	1998337..1998462 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH39_RS10200 (EQH39_10710)	rlmH	1998744..1999223 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH39_RS10205 (EQH39_10715)	htrA	1999406..2000587 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
EQH39_RS10210 (EQH39_10720)	spo0J	2000645..2001403 (+)	759	WP_000410377.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=337097 EQH39_RS10180 WP_000866065.1 1996242..1996994(-) (comE) [Streptococcus pneumoniae strain TVO_1901948]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=337097 EQH39_RS10180 WP_000866065.1 1996242..1996994(-) (comE) [Streptococcus pneumoniae strain TVO_1901948]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408