Detailed information NTG0337100

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: EQH39_RS10205
• Genome accession: NZ_CP035241
• Coordinates: 1999406..2000587 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681601.1
• Uniprot ID: A0A0B7LRW6
• Organism: Streptococcus pneumoniae strain TVO_1901948
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 1994406..2005587

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH39_RS10165 (EQH39_10675)	-	1995457..1995999 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH39_RS10180 (EQH39_10690)	comE	1996242..1996994 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH39_RS10185 (EQH39_10695)	comD/comD1	1996991..1998316 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
EQH39_RS10190 (EQH39_10700)	comC/comC1	1998337..1998462 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH39_RS10200 (EQH39_10710)	rlmH	1998744..1999223 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH39_RS10205 (EQH39_10715)	htrA	1999406..2000587 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
EQH39_RS10210 (EQH39_10720)	spo0J	2000645..2001403 (+)	759	WP_000410377.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41855.70 Da
• Isoelectric Point: 6.8902

>NTDB_id=337100 EQH39_RS10205 WP_000681601.1 1999406..2000587(+) (htrA) [Streptococcus pneumoniae strain TVO_1901948]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=337100 EQH39_RS10205 WP_000681601.1 1999406..2000587(+) (htrA) [Streptococcus pneumoniae strain TVO_1901948]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0B7LRW6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.491	100	0.995
htrA	Streptococcus pneumoniae D39	99.491	100	0.995
htrA	Streptococcus pneumoniae R6	99.491	100	0.995
htrA	Streptococcus pneumoniae TIGR4	99.491	100	0.995
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.919	100	0.674
htrA	Streptococcus mutans UA159	54.822	100	0.55