Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   SP670_RS11090 Genome accession   NC_014498
Coordinates   2031548..2032489 (-) Length   313 a.a.
NCBI ID   WP_000249563.1    Uniprot ID   -
Organism   Streptococcus pneumoniae 670-6B     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2026548..2037489
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP670_RS13970 (SP670_2185) - 2026565..2026735 (-) 171 WP_000656630.1 hypothetical protein -
  SP670_RS13975 - 2026732..2026875 (-) 144 WP_000389590.1 hypothetical protein -
  SP670_RS14525 (SP670_2186) - 2027270..2027392 (-) 123 WP_001003831.1 hypothetical protein -
  SP670_RS11065 (SP670_2187) - 2027469..2027744 (-) 276 WP_001094376.1 hypothetical protein -
  SP670_RS11070 (SP670_2188) - 2027906..2028673 (+) 768 WP_000862003.1 S24 family peptidase -
  SP670_RS11075 - 2028675..2028875 (+) 201 WP_000064302.1 hypothetical protein -
  SP670_RS11080 (SP670_2190) - 2029057..2030502 (+) 1446 WP_000633509.1 recombinase family protein -
  SP670_RS11085 (SP670_2191) comGB/cglB 2030584..2031600 (-) 1017 WP_000355367.1 competence type IV pilus assembly protein ComGB Machinery gene
  SP670_RS11090 (SP670_2192) comGA/cglA/cilD 2031548..2032489 (-) 942 WP_000249563.1 competence type IV pilus ATPase ComGA Machinery gene
  SP670_RS11095 (SP670_2193) - 2032565..2032930 (-) 366 WP_000286415.1 DUF1033 family protein -
  SP670_RS11100 (SP670_2194) - 2033081..2034139 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  SP670_RS11105 (SP670_2195) nagA 2034302..2035453 (-) 1152 WP_001134546.1 N-acetylglucosamine-6-phosphate deacetylase -
  SP670_RS11110 (SP670_2196) - 2035605..2037422 (-) 1818 WP_001220854.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35646.65 Da        Isoelectric Point: 6.1826

>NTDB_id=32879 SP670_RS11090 WP_000249563.1 2031548..2032489(-) (comGA/cglA/cilD) [Streptococcus pneumoniae 670-6B]
MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGCYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDDQMASLRLSTVGDYRGHESLVIRLLHDEKQELHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELAKSLFKGQQ
VMSIEDPVEIKQDNMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANKDYQEHQPTRWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=32879 SP670_RS11090 WP_000249563.1 2031548..2032489(-) (comGA/cglA/cilD) [Streptococcus pneumoniae 670-6B]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGATATCTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATCGGTTGTTATGATTTTGAAAAGTTTGCGGCCG
TCATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTTGGAGAAAAGCGACGTAGTCAACTGGGTTCCTGCGATTATGCC
TATGACGATCAGATGGCGTCACTACGTTTATCTACCGTAGGTGATTATAGAGGGCATGAGAGTTTAGTTATTCGTTTGTT
GCATGATGAGAAGCAGGAGTTGCATTTTTGGTTTCAGGATATTGAAGAATTGGGCAAGCAGTACAGGCAACGTGGTCTCT
ATCTCTTTGCTGGCCCAGTCGGCAGTGGCAAGACAACCTTGATGCATGAATTGGCTAAATCTCTCTTTAAAGGACAGCAA
GTTATGTCCATTGAAGATCCTGTCGAAATCAAGCAGGACAACATGCTCCAGTTGCAGTTGAATGAAGCGATTGGGCTTAC
CTATGAAAATCTAATCAAACTTTCCTTGCGCCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCATGCCAAGAGTATTCGAGGTGTTTAT
GAGCGCCTGCTGGAGTTGGGTGTGAGTGAGGAGGAATTAGCAGTCGTTCTTCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAAAGACTATCAAGAACACCAGCCAACTAGGTGGAATGAGCAGATTGACCAGC
TTCTTAAAGATGGACATATCACAAGCCTTCAAGCTGAAACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterProScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

97.125

100

0.971
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

95.847

100

0.958
  comGA/cglA/cilD Streptococcus pneumoniae D39

95.847

100

0.958
  comGA/cglA/cilD Streptococcus pneumoniae R6

95.847

100

0.958
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

95.847

100

0.958
  comGA Streptococcus gordonii str. Challis substr. CH1

78.387

99.042

0.776
  comGA Streptococcus mutans UA159

64.952

99.361

0.645
  comGA Streptococcus mutans UA140

64.952

99.361

0.645
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

63.226

99.042

0.626
  comGA Lactococcus lactis subsp. cremoris KW2

55.449

99.681

0.553
  comGA Latilactobacillus sakei subsp. sakei 23K

43.774

84.665

0.371

Multiple sequence alignment