Detailed information NTG0323110

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EB816_RS01150
• Genome accession: NZ_CP033337
• Coordinates: 197175..197912 (+)
• Length: 245 a.a.
• NCBI ID: WP_023612237.1
• Uniprot ID: A0A5S4TLW8
• Organism: Streptococcus pyogenes strain TSPY453
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 192175..202912

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EB816_RS01120 (EB816_01120)	-	192649..193428 (+)	780	WP_023612239.1	MBL fold metallo-hydrolase	-
EB816_RS01125 (EB816_01125)	tadA	193428..193943 (+)	516	WP_002992549.1	tRNA adenosine(34) deaminase TadA	-
EB816_RS01130 (EB816_01130)	-	194557..195789 (-)	1233	WP_032465583.1	transglutaminase domain-containing protein	-
EB816_RS01140 (EB816_01140)	-	196264..196641 (-)	378	WP_023612231.1	hypothetical protein	-
EB816_RS01145 (EB816_01145)	-	196834..197166 (+)	333	WP_023612241.1	LytTR family DNA-binding domain-containing protein	-
EB816_RS01150 (EB816_01150)	comE/blpR	197175..197912 (+)	738	WP_023612237.1	response regulator transcription factor	Regulator
EB816_RS01155 (EB816_01155)	-	197912..199255 (+)	1344	WP_032465581.1	GHKL domain-containing protein	-
EB816_RS10105	-	199326..199469 (-)	144	WP_023612234.1	hypothetical protein	-
EB816_RS10425	-	200244..200375 (+)	132	WP_023612236.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28280.35 Da
• Isoelectric Point: 6.6988

>NTDB_id=323110 EB816_RS01150 WP_023612237.1 197175..197912(+) (comE/blpR) [Streptococcus pyogenes strain TSPY453]
MLNIFILEDDFIQQSRLEKAVLACVRSTVVKYKTLEVFGKPNQLLGAIQETGNHQFFFLDIEIKGEEKKGMEIAREIRER
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLSNDEFQKAVTDVLVHAFENIDHTVAENSFIYKTENAHIQVPFSDIL
YFETSTTIHKVTLKTKTGQLEFYGKVSEISKADNRLYLAHRSYVVNPANVTKIDRTNHIIYFENGDSCLVSRLKQKKLVD
LVENK

Nucleotide

• Length: 738 bp

>NTDB_id=323110 EB816_RS01150 WP_023612237.1 197175..197912(+) (comE/blpR) [Streptococcus pyogenes strain TSPY453]
ATGTTAAATATTTTTATTTTAGAGGATGATTTTATCCAGCAGTCTCGATTGGAGAAAGCTGTTTTAGCATGTGTTCGGTC
AACAGTGGTAAAATATAAAACATTAGAAGTTTTTGGGAAACCTAATCAATTATTAGGTGCTATTCAAGAAACGGGGAATC
ACCAATTTTTCTTTTTGGACATCGAGATAAAAGGTGAGGAGAAGAAGGGGATGGAGATAGCACGTGAGATTCGTGAGCGA
GATCCCTATGCCGTTATTGTTTTTGTGACGACTCACTCTGAATTCATGCCAGTAACTTATCGCTATCGAGTCTCAGCTTT
GGATTTTATTGATAAAGGTTTATCAAATGATGAGTTTCAAAAGGCTGTTACAGATGTTTTAGTGCATGCCTTTGAAAACA
TTGATCATACAGTAGCCGAAAATTCATTTATTTATAAGACAGAAAATGCACATATTCAAGTTCCTTTTAGCGATATCTTA
TATTTTGAAACGTCAACAACTATTCATAAAGTGACTTTAAAAACTAAAACGGGTCAATTAGAATTTTATGGTAAGGTGTC
TGAAATTTCAAAGGCGGATAATCGTCTTTATCTTGCTCATAGATCCTATGTTGTAAACCCAGCAAATGTGACAAAAATAG
ATAGAACAAATCATATTATCTATTTTGAAAATGGAGATTCATGCTTAGTATCAAGATTAAAGCAAAAGAAGTTAGTAGAT
TTGGTGGAGAATAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-241)

3D structure

• AlphaFold DB: A0A5S4TLW8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.252	100	0.535
comE/comE1	Streptococcus equinus JB1	48.954	97.551	0.478
comE	Streptococcus mitis SK321	37.945	100	0.392
comE	Streptococcus pneumoniae Rx1	37.945	100	0.392
comE	Streptococcus pneumoniae D39	37.945	100	0.392
comE	Streptococcus pneumoniae R6	37.945	100	0.392
comE	Streptococcus pneumoniae TIGR4	37.945	100	0.392
comE	Streptococcus mitis NCTC 12261	37.945	100	0.392
comE/comE2	Streptococcus equinus JB1	39.344	99.592	0.392
comE	Streptococcus infantis strain Atu-4	37.549	100	0.388
comE/comE2	Streptococcus gordonii strain NCTC7865	36.694	100	0.371
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	36.694	100	0.371