Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   D7D53_RS00210 Genome accession   NZ_CP032621
Coordinates   42601..43857 (+) Length   418 a.a.
NCBI ID   WP_120769761.1    Uniprot ID   A0A387AY60
Organism   Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 43164..78791 42601..43857 flank -693


Gene organization within MGE regions


Location: 42601..78791
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D7D53_RS00210 (D7D53_00210) cinA 42601..43857 (+) 1257 WP_120769761.1 competence/damage-inducible protein A Machinery gene
  D7D53_RS00215 (D7D53_00215) recA 43912..45066 (+) 1155 WP_070479987.1 recombinase RecA Machinery gene
  D7D53_RS00220 (D7D53_00220) - 45181..46551 (+) 1371 WP_120769762.1 MATE family efflux transporter -
  D7D53_RS00225 (D7D53_00225) - 46648..47364 (+) 717 WP_023940351.1 YebC/PmpR family DNA-binding transcriptional regulator -
  D7D53_RS00230 (D7D53_00230) - 47414..48061 (-) 648 WP_120769763.1 DUF308 domain-containing protein -
  D7D53_RS00235 (D7D53_00235) - 48275..48745 (+) 471 WP_120769764.1 MarR family winged helix-turn-helix transcriptional regulator -
  D7D53_RS00240 (D7D53_00240) rcrP 48720..50489 (+) 1770 WP_120769765.1 ABC transporter ATP-binding protein Regulator
  D7D53_RS00245 (D7D53_00245) rcrQ 50479..52239 (+) 1761 WP_120769766.1 ABC transporter ATP-binding protein Regulator
  D7D53_RS00250 (D7D53_00250) - 52335..52838 (+) 504 WP_162927856.1 phosphatase PAP2 family protein -
  D7D53_RS00255 (D7D53_00255) - 52952..53398 (+) 447 WP_120769768.1 LytTR family DNA-binding domain-containing protein -
  D7D53_RS00260 (D7D53_00260) - 53403..54077 (+) 675 WP_120769769.1 LiaF transmembrane domain-containing protein -
  D7D53_RS00265 (D7D53_00265) - 54198..54566 (+) 369 WP_033681017.1 hypothetical protein -
  D7D53_RS00270 (D7D53_00270) - 54690..54872 (+) 183 WP_009729741.1 hypothetical protein -
  D7D53_RS00275 (D7D53_00275) - 54872..55996 (+) 1125 WP_033681018.1 replication initiator protein A -
  D7D53_RS09965 - 55990..56157 (+) 168 WP_000910110.1 hypothetical protein -
  D7D53_RS00280 (D7D53_00280) - 56162..56428 (+) 267 WP_033681019.1 hypothetical protein -
  D7D53_RS10255 - 56451..56585 (+) 135 WP_265182510.1 hypothetical protein -
  D7D53_RS00285 (D7D53_00285) - 56588..56803 (+) 216 WP_033681021.1 helix-turn-helix transcriptional regulator -
  D7D53_RS00290 (D7D53_00290) - 57094..57396 (+) 303 WP_033681022.1 hypothetical protein -
  D7D53_RS00295 (D7D53_00295) - 57415..58197 (+) 783 WP_033681023.1 LPXTG cell wall anchor domain-containing protein -
  D7D53_RS00300 (D7D53_00300) - 58216..61245 (+) 3030 WP_120769770.1 SspB-related isopeptide-forming adhesin -
  D7D53_RS00305 (D7D53_00305) - 61309..61809 (+) 501 WP_033681025.1 hypothetical protein -
  D7D53_RS00310 (D7D53_00310) - 61883..62107 (+) 225 WP_000340303.1 hypothetical protein -
  D7D53_RS00315 (D7D53_00315) - 62135..62884 (+) 750 WP_033681026.1 hypothetical protein -
  D7D53_RS00320 (D7D53_00320) - 62926..64038 (+) 1113 WP_033681027.1 hypothetical protein -
  D7D53_RS00325 (D7D53_00325) - 64100..64321 (+) 222 WP_001047223.1 hypothetical protein -
  D7D53_RS00330 (D7D53_00330) - 64318..64665 (+) 348 WP_000197459.1 PrgI family mobile element protein -
  D7D53_RS00335 (D7D53_00335) - 64625..66979 (+) 2355 WP_033681029.1 VirB4-like conjugal transfer ATPase, CD1110 family -
  D7D53_RS00340 (D7D53_00340) - 67005..69641 (+) 2637 WP_033681031.1 phage tail tip lysozyme -
  D7D53_RS00345 (D7D53_00345) - 69661..70305 (+) 645 WP_033681032.1 hypothetical protein -
  D7D53_RS00350 (D7D53_00350) - 70302..70574 (+) 273 WP_033681033.1 hypothetical protein -
  D7D53_RS00355 (D7D53_00355) - 70528..71367 (+) 840 WP_033681035.1 hypothetical protein -
  D7D53_RS00360 (D7D53_00360) - 71380..71898 (+) 519 WP_033681036.1 hypothetical protein -
  D7D53_RS00365 (D7D53_00365) - 71895..73694 (+) 1800 WP_033681037.1 VirD4-like conjugal transfer protein, CD1115 family -
  D7D53_RS00370 (D7D53_00370) - 73715..73978 (+) 264 WP_000449753.1 hypothetical protein -
  D7D53_RS00375 (D7D53_00375) - 73969..78306 (+) 4338 WP_033681038.1 PBECR4 domain-containing protein -

Sequence

Protein


Download         Length: 418 a.a.        Molecular weight: 45116.34 Da        Isoelectric Point: 4.5335

>NTDB_id=317165 D7D53_RS00210 WP_120769761.1 42601..43857(+) (cinA) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLAEIGVDVYFQTAVGDNEARLLSLLKIASQRSSLVILTGGLGPTEDDLTKQT
LAKFLGKELVFDPQAQEKLDVFFAQRPDYARTPNNERQAQLVEGATPLPNETGLAVGGILEVDGVNYVVLPGPPSELKPM
VLNQLLPKLMTGSKLYSRVLRFFGIGESQLVTILSDLIDNQTDPTLAPYAKTGEVTLRLSTKVSSQEEANQALDILENQI
LDRQTFEGISLRELCYGYGEESSLASIVVEELKKQGKTITAAESLTAGLFQATVADFSGASSIFKGGFVTYSLEEKSRML
DIPAKDLEEQGVVSEFTAQKMAEQARSKTQSDFGLSLTGVAGPDSLEGYPAGTVFLGLAQEHGTEVIKVNIGGRSRADVR
HIAVMHAFNLVRKALLSD

Nucleotide


Download         Length: 1257 bp        

>NTDB_id=317165 D7D53_RS00210 WP_120769761.1 42601..43857(+) (cinA) [Streptococcus gwangjuensis strain KCOM 1679 (=ChDC B345)]
ATGAAAGCAGAAATCATTGCTGTTGGAACAGAGATTTTGACAGGACAGATTGTCAATACCAATGCTCAGTTTTTATCAGA
AAAACTAGCAGAGATTGGGGTAGACGTATATTTTCAGACGGCTGTAGGAGACAATGAAGCTCGTCTCTTATCCCTGCTTA
AGATTGCCAGTCAACGTAGCAGTCTGGTGATTTTGACAGGTGGTTTGGGGCCAACTGAGGACGATCTAACCAAACAAACC
CTAGCTAAATTTTTAGGGAAAGAATTAGTCTTCGATCCTCAGGCGCAGGAGAAGTTGGATGTCTTTTTTGCCCAGAGACC
AGACTATGCCCGAACACCGAATAATGAAAGACAAGCTCAACTTGTAGAAGGGGCGACTCCACTACCAAACGAAACAGGAC
TGGCTGTGGGGGGAATATTGGAAGTCGATGGAGTGAACTATGTCGTCCTTCCCGGTCCACCAAGTGAATTAAAACCCATG
GTTTTAAACCAACTTCTACCTAAGTTGATGACAGGGAGTAAGCTATATTCCCGCGTTCTTCGTTTCTTTGGGATTGGCGA
AAGTCAGTTGGTTACGATTTTGTCTGATTTGATTGATAATCAAACAGATCCGACCTTGGCCCCTTATGCTAAGACAGGAG
AAGTCACTCTGCGTCTGTCAACAAAGGTTAGCAGTCAAGAAGAGGCGAATCAAGCGCTGGATATCTTAGAAAACCAAATC
TTGGACCGCCAGACTTTCGAAGGAATTTCTTTACGAGAACTTTGTTATGGTTATGGGGAAGAGTCCAGTTTAGCTAGCAT
TGTGGTAGAAGAGCTGAAAAAACAAGGGAAAACCATCACGGCTGCTGAGAGTTTGACGGCAGGGCTTTTCCAAGCCACTG
TGGCAGATTTTTCGGGTGCATCAAGTATATTCAAGGGTGGTTTTGTGACCTATAGCTTGGAGGAAAAATCAAGGATGTTG
GATATTCCTGCCAAGGATTTAGAAGAACAGGGTGTGGTGTCTGAATTTACAGCGCAGAAGATGGCTGAGCAGGCACGAAG
TAAGACCCAGTCTGATTTTGGTCTTAGTTTGACTGGAGTGGCAGGACCAGATAGCCTAGAAGGGTATCCAGCTGGGACAG
TCTTCCTAGGATTGGCACAGGAGCATGGAACTGAGGTCATCAAGGTTAATATTGGAGGCAGAAGTCGAGCAGATGTACGT
CACATTGCGGTTATGCATGCCTTTAACCTAGTTCGCAAGGCTTTATTAAGTGACTAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(262-414)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-169)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-243)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A387AY60

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

96.411

100

0.964
  cinA Streptococcus mitis NCTC 12261

95.455

100

0.955
  cinA Streptococcus pneumoniae TIGR4

93.062

100

0.931
  cinA Streptococcus pneumoniae Rx1

92.823

100

0.928
  cinA Streptococcus pneumoniae R6

92.823

100

0.928
  cinA Streptococcus pneumoniae D39

92.584

100

0.926
  cinA Streptococcus mutans UA159

71.292

100

0.713
  cinA Streptococcus suis isolate S10

54.087

99.522

0.538
  cinA Bacillus subtilis subsp. subtilis str. 168

45.455

100

0.455

Multiple sequence alignment