Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   D2E16_RS11810 Genome accession   NZ_CP032064
Coordinates   2434471..2435208 (-) Length   245 a.a.
NCBI ID   WP_029185755.1    Uniprot ID   A0A0Z8WLM9
Organism   Streptococcus suis strain YSJ17     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2429471..2440208
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D2E16_RS11765 (D2E16_12155) - 2429523..2429864 (+) 342 WP_024377605.1 type II toxin-antitoxin system RelE/ParE family toxin -
  D2E16_RS11770 (D2E16_12160) - 2430175..2430876 (-) 702 WP_105148918.1 CPBP family intramembrane glutamic endopeptidase -
  D2E16_RS11775 (D2E16_12165) - 2431311..2431493 (-) 183 WP_105148919.1 hypothetical protein -
  D2E16_RS11780 (D2E16_12170) - 2431521..2431730 (-) 210 WP_029187560.1 hypothetical protein -
  D2E16_RS11785 (D2E16_12175) - 2431841..2432050 (-) 210 WP_029943372.1 hypothetical protein -
  D2E16_RS11790 - 2432068..2432229 (-) 162 WP_153308667.1 hypothetical protein -
  D2E16_RS11795 - 2432537..2432704 (-) 168 WP_153308668.1 hypothetical protein -
  D2E16_RS11800 - 2432786..2432950 (-) 165 WP_192369095.1 hypothetical protein -
  D2E16_RS11805 (D2E16_12185) - 2433131..2434471 (-) 1341 WP_174850962.1 GHKL domain-containing protein -
  D2E16_RS11810 (D2E16_12190) comE/blpR 2434471..2435208 (-) 738 WP_029185755.1 response regulator transcription factor Regulator
  D2E16_RS11815 (D2E16_12195) - 2435426..2435569 (-) 144 WP_024403054.1 putative holin-like toxin -
  D2E16_RS11820 (D2E16_12200) - 2435806..2435907 (-) 102 WP_153052760.1 putative holin-like toxin -
  D2E16_RS11825 (D2E16_12205) - 2436061..2436246 (-) 186 WP_024407687.1 hypothetical protein -
  D2E16_RS11830 (D2E16_12210) dtd 2436309..2436752 (-) 444 WP_105146202.1 D-aminoacyl-tRNA deacylase -
  D2E16_RS11835 (D2E16_12215) - 2436754..2438955 (-) 2202 WP_002941987.1 RelA/SpoT family protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28340.16 Da        Isoelectric Point: 5.0757

>NTDB_id=313553 D2E16_RS11810 WP_029185755.1 2434471..2435208(-) (comE/blpR) [Streptococcus suis strain YSJ17]
MLNIFVLEDDFFQQSRLENAIRQCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFVYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITKLDRANHIAYFENGDSCFVSRLKQKKLAD
LLEID

Nucleotide


Download         Length: 738 bp        

>NTDB_id=313553 D2E16_RS11810 WP_029185755.1 2434471..2435208(-) (comE/blpR) [Streptococcus suis strain YSJ17]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGCAGGCTAGAAAATGCTATTAGGCAGTGTGTTGAAGA
AACGTCAGTAAGATATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAATTATTGGAATCAATCGAGGAAGCGGGGAATC
ACCAATTTTTCTTTTTAGATATTGAAATTAAAGGCGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATCCGTGCTCGC
GATCCCTATGCAGTCATTGTCTTTGTAACAACTCATTCAGAATTTATGCCGGTAACATATCGTTATCGGGTTTCTGCTTT
AGATTTTATAGATAAAGGCCTGGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTGTATACAAAACTGAAACTGCTCATATTCAAGTTCCTTTTAGCGACATCCTT
TATTTTGAAACATCATCAACGATTCATAAAGTTATTTTAAAAACGAAAACAGGTCAGACTGAGTTTTATGGGAAGGTATC
CGATATAGCTAAAGCTGATGAACGACTTTACCAAGCACATCGTTCTTGTGTAGTGAATCCTTTAAATATAACGAAGTTGG
ACAGAGCAAACCATATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGTTGGAGATTGATTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0Z8WLM9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.23

97.551

0.539
  comE/comE1 Streptococcus equinus JB1

50

97.143

0.486
  comE/comE2 Streptococcus equinus JB1

41.152

99.184

0.408
  comE Streptococcus mitis SK321

38.554

100

0.392
  comE Streptococcus pneumoniae R6

38.554

100

0.392
  comE Streptococcus pneumoniae TIGR4

38.554

100

0.392
  comE Streptococcus infantis strain Atu-4

38.554

100

0.392
  comE Streptococcus mitis NCTC 12261

38.554

100

0.392
  comE Streptococcus pneumoniae Rx1

38.554

100

0.392
  comE Streptococcus pneumoniae D39

38.554

100

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.618

100

0.388
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.618

100

0.388

Multiple sequence alignment