Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   DP112_RS10525 Genome accession   NZ_CP030125
Coordinates   2127245..2127982 (-) Length   245 a.a.
NCBI ID   WP_105150779.1    Uniprot ID   -
Organism   Streptococcus suis strain HA1003     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2125312..2140714 2127245..2127982 within 0


Gene organization within MGE regions


Location: 2125312..2140714
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DP112_RS10515 (DP112_10520) - 2125312..2125731 (-) 420 WP_029171304.1 hypothetical protein -
  DP112_RS10520 (DP112_10525) - 2125911..2127248 (-) 1338 WP_241146860.1 GHKL domain-containing protein -
  DP112_RS10525 (DP112_10530) comE/blpR 2127245..2127982 (-) 738 WP_105150779.1 response regulator transcription factor Regulator
  DP112_RS11330 - 2128198..2128272 (-) 75 WP_238137233.1 hypothetical protein -
  DP112_RS10535 (DP112_10540) - 2128574..2128759 (-) 186 WP_024384320.1 hypothetical protein -
  DP112_RS10540 (DP112_10545) dtd 2128836..2129279 (-) 444 WP_105134330.1 D-aminoacyl-tRNA deacylase -
  DP112_RS10545 (DP112_10550) - 2129281..2131482 (-) 2202 WP_024407689.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
  DP112_RS10550 (DP112_10555) sntA 2131738..2134179 (+) 2442 WP_114866952.1 heme-binding protein SntA -
  DP112_RS10555 (DP112_10560) - 2134301..2134858 (-) 558 WP_114866953.1 hypothetical protein -
  DP112_RS10560 (DP112_10565) - 2135101..2135817 (-) 717 WP_114866954.1 DUF554 domain-containing protein -
  DP112_RS10565 (DP112_10570) - 2135821..2136567 (-) 747 WP_114866955.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
  DP112_RS10570 (DP112_10575) prmA 2136569..2137522 (-) 954 WP_114866956.1 50S ribosomal protein L11 methyltransferase -
  DP112_RS10575 (DP112_10580) - 2137573..2138523 (-) 951 WP_105136562.1 hypothetical protein -
  DP112_RS10580 (DP112_10585) - 2138551..2139021 (-) 471 WP_024407698.1 DUF3013 family protein -
  DP112_RS10585 (DP112_10590) - 2139023..2139358 (-) 336 WP_024407699.1 MazG nucleotide pyrophosphohydrolase domain-containing protein -
  DP112_RS10590 (DP112_10595) - 2139428..2140714 (+) 1287 WP_114866957.1 replication-associated recombination protein A -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28424.41 Da        Isoelectric Point: 6.3055

>NTDB_id=299507 DP112_RS10525 WP_105150779.1 2127245..2127982(-) (comE/blpR) [Streptococcus suis strain HA1003]
MLNIFVLEDDFFQQSRLENAIRRCVEETSVRYKFLEVFGKPNQLLESIEETGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFRKAVSDVLVHAFENIDHTVAENSFVYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADKRLYQAHRSCVVNPLNITKLDRANHIAYFENGDSCFVSRLKQKKLAD
LLEIK

Nucleotide


Download         Length: 738 bp        

>NTDB_id=299507 DP112_RS10525 WP_105150779.1 2127245..2127982(-) (comE/blpR) [Streptococcus suis strain HA1003]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGTAGGTTAGAAAATGCTATTAGGCGGTGTGTTGAAGA
AACGTCTGTAAGATATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAATTATTGGAATCAATCGAGGAAACGGGCAATC
ACCAATTTTTCTTTTTAGATATTGAAATAAAAGGCGAAGAAAAGAAAGGAATGGAAATCGCTAAAGAAATTCGTGCTCGC
GATCCCTACGCTGTTATTGTCTTTGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTATCGGGTTTCTGCTTT
AGATTTTATAGATAAAGGTCTGGAGGATAGTGACTTTCGAAAGGCAGTATCAGATGTGTTAGTACATGCTTTTGAAAATA
TTGATCATACTGTAGCTGAAAATTCTTTTGTATACAAAACTGAAACTGCTCATATTCAAGTTCCTTTTAGTGACATCCTT
TATTTTGAAACATCATCAACGATTCATAAAGTCATTTTAAAAACCAAAACAGGTCAGACTGAATTTTACGGGAAAGTATC
GGATATAGCGAAAGCTGATAAACGACTTTACCAAGCACATCGTTCTTGTGTAGTGAATCCTTTAAATATAACGAAGTTGG
ACAGAGCAAACCACATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGTTGGAGATTAAATGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.649

97.551

0.543
  comE/comE1 Streptococcus equinus JB1

50.42

97.143

0.49
  comE/comE2 Streptococcus equinus JB1

40.741

99.184

0.404
  comE Streptococcus mitis SK321

39.044

100

0.4
  comE Streptococcus pneumoniae R6

39.044

100

0.4
  comE Streptococcus pneumoniae TIGR4

39.044

100

0.4
  comE Streptococcus infantis strain Atu-4

39.044

100

0.4
  comE Streptococcus mitis NCTC 12261

39.044

100

0.4
  comE Streptococcus pneumoniae Rx1

39.044

100

0.4
  comE Streptococcus pneumoniae D39

39.044

100

0.4
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

39.113

100

0.396
  comE/comE2 Streptococcus gordonii strain NCTC7865

39.113

100

0.396

Multiple sequence alignment