Detailed information NTG0029713

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SUB_RS08315
• Genome accession: NC_012004
• Coordinates: 1648972..1649709 (-)
• Length: 245 a.a.
• NCBI ID: WP_015911967.1
• Uniprot ID: B9DVW0
• Organism: Streptococcus uberis 0140J
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1643972..1654709

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SUB_RS08295 (SUB1666)	-	1644682..1645458 (-)	777	WP_100912337.1	YidC/Oxa1 family membrane protein insertase	-
SUB_RS08300 (SUB1667)	rnpA	1645478..1645837 (-)	360	WP_015911964.1	ribonuclease P protein component	-
SUB_RS08305 (SUB1668)	argH	1645925..1647307 (-)	1383	WP_015911965.1	argininosuccinate lyase	-
SUB_RS08310 (SUB1669)	-	1647304..1648503 (-)	1200	WP_015911966.1	argininosuccinate synthase	-
SUB_RS08315 (SUB1670)	comE/blpR	1648972..1649709 (-)	738	WP_015911967.1	response regulator transcription factor	Regulator
SUB_RS08320 (SUB1671)	-	1649711..1651021 (-)	1311	WP_015911968.1	GHKL domain-containing protein	-
SUB_RS09745	-	1651018..1651827 (-)	810	WP_195847458.1	GHKL domain-containing protein	-
SUB_RS09750	-	1651887..1652369 (-)	483	WP_050712771.1	hypothetical protein	-
SUB_RS08330 (SUB1674)	-	1652443..1653759 (-)	1317	WP_015911969.1	sensor histidine kinase	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28829.22 Da
• Isoelectric Point: 5.0809

>NTDB_id=29713 SUB_RS08315 WP_015911967.1 1648972..1649709(-) (comE/blpR) [Streptococcus uberis 0140J]
MNIFILEDDFIQQNRIEATIEEVLQEQKITVSYIEVFSNPDKLLDSIHERGDHQLFFLDIEIKNATKKGLEVASEIRKMD
PNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDNQQFKEQISECIQYTKKMMSTKEPEEMFHFETAQARLKLPQKDILY
FATSTTPHKVCLWTLTERLEFYGNLSEIQEVAPKLFLCHRSFLVNLENVVRIDKFDQMLYFENGDSCPVSRLKMKQLIEK
WEMLH

Nucleotide

• Length: 738 bp

>NTDB_id=29713 SUB_RS08315 WP_015911967.1 1648972..1649709(-) (comE/blpR) [Streptococcus uberis 0140J]
ATGAACATTTTTATTCTTGAAGATGATTTTATTCAACAAAATCGTATAGAAGCAACGATTGAAGAAGTTTTGCAAGAGCA
AAAAATCACCGTTAGTTATATAGAAGTTTTTTCGAATCCAGATAAACTACTAGATAGCATTCATGAACGTGGTGATCATC
AATTATTCTTTTTAGATATTGAGATAAAAAATGCCACAAAGAAAGGGCTTGAAGTAGCTTCTGAAATTAGAAAAATGGAT
CCCAATGCGGTCATTGTTTTTGTCACAACACATTCAGAATTTGCTCCAATTTCATTTAAATACAAAGTGTCAGCCCTAGA
TTTCATTGATAAAGCTGTTGATAATCAACAGTTTAAAGAACAAATTAGTGAGTGCATTCAATATACCAAAAAAATGATGT
CTACAAAGGAGCCTGAGGAAATGTTTCACTTTGAGACAGCTCAGGCTCGATTAAAATTACCTCAGAAAGATATCCTCTAT
TTCGCTACTTCAACGACACCTCATAAAGTGTGTCTATGGACTTTAACGGAACGTTTAGAATTTTATGGAAACCTTTCAGA
AATTCAGGAAGTTGCACCGAAGCTATTCTTATGTCACAGATCGTTTTTGGTTAATCTTGAAAATGTGGTTCGTATTGATA
AATTTGATCAAATGCTCTATTTTGAAAATGGCGATTCTTGTCCGGTTTCAAGGTTAAAAATGAAGCAATTAATCGAAAAA
TGGGAAATGTTACACTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: B9DVW0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.899	97.143	0.465
comE/comE1	Streptococcus equinus JB1	43.697	97.143	0.424
comE/comE2	Streptococcus equinus JB1	40.574	99.592	0.404
comE/comE2	Streptococcus gordonii strain NCTC7865	37.6	100	0.384
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.6	100	0.384
comE	Streptococcus pneumoniae TIGR4	38.589	98.367	0.38
comE	Streptococcus mitis SK321	38.589	98.367	0.38
comE	Streptococcus mitis NCTC 12261	38.589	98.367	0.38
comE	Streptococcus infantis strain Atu-4	38.589	98.367	0.38
comE	Streptococcus pneumoniae Rx1	38.589	98.367	0.38
comE	Streptococcus pneumoniae D39	38.589	98.367	0.38
comE	Streptococcus pneumoniae R6	38.589	98.367	0.38