Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   SSA_RS11660 Genome accession   NC_009009
Coordinates   2383219..2383983 (-) Length   254 a.a.
NCBI ID   WP_002899529.1    Uniprot ID   -
Organism   Streptococcus sanguinis SK36     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2378219..2388983
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SSA_RS11640 (SSA_2376) - 2378626..2380248 (+) 1623 WP_033179248.1 ATP-binding cassette domain-containing protein -
  SSA_RS11645 (SSA_2377) - 2380324..2382909 (+) 2586 WP_011837728.1 YfhO family protein -
  SSA_RS11660 (SSA_2378) comE 2383219..2383983 (-) 765 WP_002899529.1 competence system response regulator transcription factor ComE Regulator
  SSA_RS11665 (SSA_2379) comD 2383989..2385323 (-) 1335 WP_011837729.1 competence system sensor histidine kinase ComD -
  SSA_RS11670 (SSA_2394) - 2385351..2385458 (-) 108 WP_002905686.1 competence protein -
  SSA_RS11680 (SSA_2380) rlmH 2385755..2386234 (-) 480 WP_011837730.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SSA_RS11685 (SSA_2381) htrA 2386438..2387610 (+) 1173 WP_002901929.1 S1C family serine protease Regulator
  SSA_RS11690 (SSA_2382) spo0J 2387674..2388435 (+) 762 WP_033179249.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 254 a.a.        Molecular weight: 29879.14 Da        Isoelectric Point: 8.0172

>NTDB_id=27554 SSA_RS11660 WP_002899529.1 2383219..2383983(-) (comE) [Streptococcus sanguinis SK36]
MKVLVLEDTVSHQVRMETTLAEIAEELGIDIQVQVTGKIKEFKKYIENGDVNQLYFLDIDIKGEETKGLEVAQFIRHHNP
YAIIVFVTSKSEFATMTFKYKVSALDFIDKDINNDAFKNRIKDSILYTKSTLIENTNMVDYFEYSYRGNDVRMPYNDILY
IETTGSSHKLRIVGKNFLKEFYGTITDIQEKDQQSKRFFSPHKSYLVNIGNIVDYDKKNREIIFYENHRCPVTRLRVKYL
KDIFENRGKRVDKA

Nucleotide


Download         Length: 765 bp        

>NTDB_id=27554 SSA_RS11660 WP_002899529.1 2383219..2383983(-) (comE) [Streptococcus sanguinis SK36]
ATGAAAGTGTTAGTTTTAGAGGATACCGTATCTCATCAAGTCAGGATGGAAACGACATTAGCAGAAATTGCTGAGGAACT
TGGAATTGACATCCAGGTTCAGGTTACAGGAAAAATCAAAGAATTCAAAAAATATATTGAAAATGGAGACGTTAACCAGC
TTTATTTTTTGGATATTGACATTAAGGGGGAGGAAACAAAAGGGCTGGAAGTAGCTCAATTTATCCGTCATCATAATCCT
TATGCCATTATAGTTTTTGTAACCTCAAAATCTGAATTTGCTACTATGACTTTTAAATATAAAGTATCAGCACTTGATTT
TATCGATAAAGATATCAACAATGATGCTTTTAAAAATAGAATCAAAGACAGTATTCTTTACACTAAGAGTACACTAATTG
AAAATACCAATATGGTAGATTATTTTGAATATAGTTATCGTGGCAATGATGTTCGAATGCCTTATAACGATATTTTGTAT
ATCGAAACGACAGGGAGCTCTCATAAACTTCGGATTGTCGGTAAAAATTTTCTCAAGGAGTTTTATGGAACGATAACAGA
TATTCAAGAAAAAGATCAGCAATCTAAACGATTTTTTTCACCCCATAAATCTTATTTGGTTAATATTGGCAACATTGTTG
ATTATGACAAGAAAAATCGAGAAATTATTTTTTACGAAAATCATCGCTGTCCGGTCACTCGTTTAAGAGTGAAATATCTG
AAAGATATTTTCGAAAATAGAGGGAAAAGAGTTGACAAAGCTTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-244)

Response regulator receiver domain (Response_reg)

(4-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus infantis strain Atu-4

68

98.425

0.669
  comE/comE2 Streptococcus gordonii strain NCTC7865

68

98.425

0.669
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

68

98.425

0.669
  comE Streptococcus mitis NCTC 12261

67.6

98.425

0.665
  comE Streptococcus mitis SK321

66.8

98.425

0.657
  comE Streptococcus pneumoniae Rx1

66.4

98.425

0.654
  comE Streptococcus pneumoniae D39

66.4

98.425

0.654
  comE Streptococcus pneumoniae R6

66.4

98.425

0.654
  comE Streptococcus pneumoniae TIGR4

66.4

98.425

0.654
  comE/blpR Streptococcus mutans UA159

38.8

98.425

0.382

Multiple sequence alignment