Detailed information NTG0027555

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SSA_RS11685
• Genome accession: NC_009009
• Coordinates: 2386438..2387610 (+)
• Length: 390 a.a.
• NCBI ID: WP_002901929.1
• Uniprot ID: A0A3R9HQD5
• Organism: Streptococcus sanguinis SK36
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2381438..2392610

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSA_RS11660 (SSA_2378)	comE	2383219..2383983 (-)	765	WP_002899529.1	competence system response regulator transcription factor ComE	Regulator
SSA_RS11665 (SSA_2379)	comD	2383989..2385323 (-)	1335	WP_011837729.1	competence system sensor histidine kinase ComD	-
SSA_RS11670 (SSA_2394)	-	2385351..2385458 (-)	108	WP_002905686.1	competence protein	-
SSA_RS11680 (SSA_2380)	rlmH	2385755..2386234 (-)	480	WP_011837730.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SSA_RS11685 (SSA_2381)	htrA	2386438..2387610 (+)	1173	WP_002901929.1	S1C family serine protease	Regulator
SSA_RS11690 (SSA_2382)	spo0J	2387674..2388435 (+)	762	WP_033179249.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 390 a.a.
• Molecular weight: 40827.59 Da
• Isoelectric Point: 4.7432

>NTDB_id=27555 SSA_RS11685 WP_002901929.1 2386438..2387610(+) (htrA) [Streptococcus sanguinis SK36]
MKNSSNAIKKALLLFAVLIVGFIGGSLGNYVTTLVTSRVKMNGNSTTSVTTSYKNSTDISEAVKKVQNAVVSVITYAESS
SSVINDESSNDESQISSEGSGVIYKKDGKSAYLVTNTHVLNGSTNVDILLADGNKVPGEVVGSDVYSDISVVKISSEKVT
DVAEFGDSGSLTVGETAIAIGSPLGTEYANSVTQGIISSLGRNVTLQSENGENISTTALQTDAAINPGNSGGPLINIQGQ
VIGITSSKISTNGQTSVEGMGFAIPSNDVVNIINQLEKNGTVTRPALGIQMMDLSNLTTSDFSKLNLPSSVKSGILVRSV
QQGMPADGKLQKNDVITKVDNTDVESTSDLQSALYKHSIGDEVEITYYRDGKSQTVKIKLTKSTKELSSN

Nucleotide

• Length: 1173 bp

>NTDB_id=27555 SSA_RS11685 WP_002901929.1 2386438..2387610(+) (htrA) [Streptococcus sanguinis SK36]
ATGAAAAACTCTTCAAATGCCATCAAAAAGGCTTTATTGCTTTTTGCAGTGTTAATTGTAGGTTTTATCGGCGGAAGTTT
AGGGAATTATGTTACTACATTAGTAACTTCACGTGTAAAAATGAATGGAAATTCAACAACCAGTGTAACTACTTCATATA
AAAACTCTACTGACATTTCAGAAGCTGTGAAAAAGGTTCAAAATGCCGTTGTTTCAGTAATTACTTATGCTGAATCTTCC
AGCAGCGTTATCAATGATGAATCTTCCAACGATGAATCACAAATCTCCAGTGAAGGTTCTGGCGTAATTTATAAAAAAGA
TGGAAAATCAGCCTATCTGGTAACCAACACCCACGTTCTTAATGGATCAACCAATGTAGATATCTTACTAGCTGATGGAA
ACAAGGTTCCAGGTGAAGTAGTTGGATCAGATGTTTATTCAGATATCTCTGTCGTTAAAATTAGTTCTGAAAAAGTAACT
GATGTCGCTGAATTTGGAGATTCTGGTTCTCTTACAGTTGGTGAAACAGCAATCGCTATCGGAAGCCCTCTTGGAACAGA
ATACGCTAACTCTGTCACACAAGGAATTATTTCTAGTTTAGGCAGAAACGTTACGTTACAATCTGAAAATGGTGAAAATA
TTTCAACAACTGCATTGCAAACAGATGCTGCAATCAATCCTGGTAACTCTGGCGGCCCTTTGATTAACATCCAAGGACAA
GTTATTGGGATTACTTCAAGTAAGATTTCAACAAATGGGCAAACCTCTGTTGAAGGGATGGGATTTGCGATTCCGTCTAA
TGATGTCGTAAATATTATCAATCAACTTGAAAAAAATGGAACAGTCACACGTCCTGCTTTAGGAATTCAAATGATGGATT
TATCTAATCTGACAACTTCTGATTTTTCTAAATTAAATCTTCCTTCTTCAGTGAAATCAGGTATTCTTGTTCGCTCTGTT
CAGCAAGGAATGCCTGCTGATGGCAAACTTCAAAAAAATGATGTCATTACAAAAGTAGATAACACAGATGTGGAATCCAC
TAGTGACCTTCAGTCTGCTCTCTACAAGCATAGCATTGGAGATGAGGTAGAGATTACTTATTATCGAGATGGTAAATCTC
AAACAGTCAAAATCAAACTCACTAAATCAACAAAAGAGTTAAGCTCAAATTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (285-380)

• Peptidase family M50 (Peptidase_M50) (231-385)

• Trypsin-like peptidase domain (Trypsin_2) (99-244)

3D structure

• AlphaFold DB: A0A3R9HQD5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	67.677	100	0.687
htrA	Streptococcus mitis NCTC 12261	64.122	100	0.646
htrA	Streptococcus pneumoniae Rx1	64.122	100	0.646
htrA	Streptococcus pneumoniae D39	64.122	100	0.646
htrA	Streptococcus pneumoniae R6	64.122	100	0.646
htrA	Streptococcus pneumoniae TIGR4	64.122	100	0.646
htrA	Streptococcus mutans UA159	54.937	100	0.556