Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   C4N11_RS10785 Genome accession   NZ_CP026670
Coordinates   2011133..2012074 (-) Length   313 a.a.
NCBI ID   WP_000249573.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain endophthalmitis isolate 335     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2006133..2017074
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C4N11_RS10745 (C4N11_10745) comYH 2006620..2007573 (-) 954 WP_000345133.1 class I SAM-dependent methyltransferase Machinery gene
  C4N11_RS10750 (C4N11_10750) - 2007634..2008228 (-) 595 Protein_2003 class I SAM-dependent methyltransferase -
  C4N11_RS10755 (C4N11_10755) comGG/cglG 2008331..2008777 (-) 447 WP_001811371.1 competence type IV pilus minor pilin ComGG Machinery gene
  C4N11_RS10760 (C4N11_10760) comGF/cglF 2008755..2009216 (-) 462 WP_000250539.1 competence type IV pilus minor pilin ComGF Machinery gene
  C4N11_RS10765 (C4N11_10765) comGE/cglE 2009179..2009481 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  C4N11_RS10770 (C4N11_10770) comGD/cglD 2009444..2009848 (-) 405 WP_000588030.1 competence type IV pilus minor pilin ComGD Machinery gene
  C4N11_RS10775 (C4N11_10775) comGC/cglC 2009841..2010167 (-) 327 WP_000738625.1 competence type IV pilus major pilin ComGC Machinery gene
  C4N11_RS10780 (C4N11_10780) comGB/cglB 2010169..2011185 (-) 1017 WP_078134418.1 competence type IV pilus assembly protein ComGB Machinery gene
  C4N11_RS10785 (C4N11_10785) comGA/cglA/cilD 2011133..2012074 (-) 942 WP_000249573.1 competence type IV pilus ATPase ComGA Machinery gene
  C4N11_RS10790 (C4N11_10790) - 2012150..2012515 (-) 366 WP_000286415.1 DUF1033 family protein -
  C4N11_RS10795 (C4N11_10795) - 2012666..2013724 (-) 1059 WP_000649468.1 zinc-dependent alcohol dehydrogenase family protein -
  C4N11_RS10800 (C4N11_10800) nagA 2013887..2015038 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  C4N11_RS10805 (C4N11_10805) - 2015191..2017008 (-) 1818 WP_001220865.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35564.49 Da        Isoelectric Point: 6.0083

>NTDB_id=271469 C4N11_RS10785 WP_000249573.1 2011133..2012074(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
MVQEIAQEIIRSARKKGTQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFASRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=271469 C4N11_RS10785 WP_000249573.1 2011133..2012074(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCAGCTCGGAAAAAAGGGACGCAGGATATTTATTTTGTCCCTAAGTT
AGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAGCAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae D39

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae R6

99.361

100

0.994
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

99.361

100

0.994
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.486

100

0.965
  comYA Streptococcus gordonii str. Challis substr. CH1

78.065

99.042

0.773
  comYA Streptococcus mutans UA159

65.916

99.361

0.655
  comYA Streptococcus mutans UA140

65.916

99.361

0.655
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.581

99.042

0.62
  comGA Lactococcus lactis subsp. cremoris KW2

54.808

99.681

0.546
  comGA Latilactobacillus sakei subsp. sakei 23K

42.642

84.665

0.361

Multiple sequence alignment