Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   CWI26_RS11435 Genome accession   NZ_CP025043
Coordinates   2312256..2312993 (-) Length   245 a.a.
NCBI ID   WP_100881810.1    Uniprot ID   A0A2I5KRQ7
Organism   Streptococcus suis strain AH681     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2307256..2317993
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CWI26_RS12035 - 2308280..2308441 (-) 162 WP_153597537.1 hypothetical protein -
  CWI26_RS12040 - 2308750..2308917 (-) 168 WP_158293418.1 hypothetical protein -
  CWI26_RS12045 - 2308991..2309152 (-) 162 WP_153308666.1 hypothetical protein -
  CWI26_RS11410 (CWI26_11410) - 2309193..2309351 (-) 159 WP_002942002.1 hypothetical protein -
  CWI26_RS11415 (CWI26_11415) - 2309458..2309667 (-) 210 WP_044678691.1 hypothetical protein -
  CWI26_RS12050 - 2309685..2309846 (-) 162 WP_153309488.1 hypothetical protein -
  CWI26_RS12055 - 2310154..2310321 (-) 168 WP_153308668.1 hypothetical protein -
  CWI26_RS12060 - 2310395..2310556 (-) 162 WP_002942006.1 hypothetical protein -
  CWI26_RS11425 (CWI26_11425) - 2310597..2310755 (-) 159 WP_002942002.1 hypothetical protein -
  CWI26_RS11430 (CWI26_11430) - 2310916..2312256 (-) 1341 WP_100881809.1 sensor histidine kinase -
  CWI26_RS11435 (CWI26_11435) comE/blpR 2312256..2312993 (-) 738 WP_100881810.1 response regulator transcription factor Regulator
  CWI26_RS12285 - 2313210..2313284 (-) 75 WP_232503818.1 hypothetical protein -
  CWI26_RS11445 (CWI26_11445) - 2313853..2314038 (-) 186 WP_024407687.1 hypothetical protein -
  CWI26_RS11450 (CWI26_11450) dtd 2314101..2314544 (-) 444 WP_100881811.1 D-aminoacyl-tRNA deacylase -
  CWI26_RS11455 (CWI26_11455) - 2314546..2316747 (-) 2202 WP_100881812.1 RelA/SpoT family protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28414.20 Da        Isoelectric Point: 5.0757

>NTDB_id=257632 CWI26_RS11435 WP_100881810.1 2312256..2312993(-) (comE/blpR) [Streptococcus suis strain AH681]
MLNIFVLEDDFFQQSRLENAIRQCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRSR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFVYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITRLDRTNHIAYFENGDSCFVSRLKQKKLAD
LLEID

Nucleotide


Download         Length: 738 bp        

>NTDB_id=257632 CWI26_RS11435 WP_100881810.1 2312256..2312993(-) (comE/blpR) [Streptococcus suis strain AH681]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGCAGGTTAGAAAATGCTATTAGGCAGTGTGTTGAAGA
AACGTCAGTAAGATATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAATTATTGGAATCAATTGAGGAAGCAGGTAATC
ACCAATTTTTCTTTTTAGATATTGAAATAAAAGGCGAAGAAAAGAAAGGAATGGAAATTGCTAAAGAAATCCGTTCTCGC
GATCCCTATGCTGTTATTGTCTTTGTAACGACACACTCAGAATTTATGCCGGTAACATATCGTTATCGGGTTTCCGCTTT
AGATTTTATAGATAAAGGCCTAGAGGATAGTGACTTTCAAAAGGCAGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTGTATACAAAACTGAAACTGCTCATATTCAAGTCCCTTTTAGTGACATCCTT
TATTTTGAAACATCATCAACGATTCATAAAGTTATTTTAAAAACGAAAACAGGTCAGACTGAGTTTTATGGGAAGGTATC
CGATATAGCGAAAGCTGATGAACGACTTTACCAAGCACATCGTTCTTGTGTAGTGAATCCATTAAATATAACAAGATTGG
ACAGAACAAATCACATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTGCAGAT
TTGTTGGAGATTGATTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-123)

LytTr DNA-binding domain (LytTR)

(152-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2I5KRQ7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.649

97.551

0.543
  comE/comE1 Streptococcus equinus JB1

50

97.143

0.486
  comE/comE2 Streptococcus equinus JB1

41.564

99.184

0.412
  comE Streptococcus pneumoniae TIGR4

38.554

100

0.392
  comE Streptococcus pneumoniae D39

38.554

100

0.392
  comE Streptococcus pneumoniae R6

38.554

100

0.392
  comE Streptococcus infantis strain Atu-4

38.554

100

0.392
  comE Streptococcus mitis NCTC 12261

38.554

100

0.392
  comE Streptococcus mitis SK321

38.554

100

0.392
  comE Streptococcus pneumoniae Rx1

38.554

100

0.392
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.618

100

0.388
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.618

100

0.388

Multiple sequence alignment