Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   CVO91_RS12200 Genome accession   NZ_CP024974
Coordinates   2414628..2415365 (-) Length   245 a.a.
NCBI ID   WP_002941995.1    Uniprot ID   A0AA87F753
Organism   Streptococcus suis strain CZ130302     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 2409628..2420365
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CVO91_RS12150 (CVO91_12150) - 2409705..2409992 (+) 288 WP_002942019.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  CVO91_RS12155 (CVO91_12155) - 2409982..2410323 (+) 342 WP_002942018.1 type II toxin-antitoxin system RelE/ParE family toxin -
  CVO91_RS12160 (CVO91_12160) - 2410418..2410612 (-) 195 WP_002942017.1 hypothetical protein -
  CVO91_RS12165 (CVO91_12165) - 2410634..2411335 (-) 702 WP_002942016.1 type II CAAX endopeptidase family protein -
  CVO91_RS12170 (CVO91_12170) - 2411339..2411563 (-) 225 WP_002942015.1 hypothetical protein -
  CVO91_RS12175 (CVO91_12175) - 2411586..2411792 (-) 207 WP_002942014.1 hypothetical protein -
  CVO91_RS13170 - 2411818..2411979 (-) 162 WP_002942013.1 hypothetical protein -
  CVO91_RS12180 (CVO91_12180) - 2412007..2412216 (-) 210 WP_002942010.1 hypothetical protein -
  CVO91_RS13175 - 2412528..2412695 (-) 168 WP_002942007.1 hypothetical protein -
  CVO91_RS13180 - 2412769..2412930 (-) 162 WP_002942006.1 hypothetical protein -
  CVO91_RS12190 (CVO91_12190) - 2412971..2413129 (-) 159 WP_002942002.1 hypothetical protein -
  CVO91_RS12195 (CVO91_12195) - 2413291..2414628 (-) 1338 WP_002941998.1 GHKL domain-containing protein -
  CVO91_RS12200 (CVO91_12200) comE/blpR 2414628..2415365 (-) 738 WP_002941995.1 response regulator transcription factor Regulator
  CVO91_RS13445 - 2415581..2415655 (-) 75 WP_232503818.1 hypothetical protein -
  CVO91_RS12215 (CVO91_12215) - 2416167..2416352 (-) 186 WP_002941993.1 hypothetical protein -
  CVO91_RS12220 (CVO91_12220) dtd 2416415..2416858 (-) 444 WP_002941990.1 D-aminoacyl-tRNA deacylase -
  CVO91_RS12225 (CVO91_12225) - 2416860..2419061 (-) 2202 WP_002941987.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28385.16 Da        Isoelectric Point: 5.3973

>NTDB_id=256949 CVO91_RS12200 WP_002941995.1 2414628..2415365(-) (comE/blpR) [Streptococcus suis strain CZ130302]
MLNIFVLEDDFFQQSRLENAIRRCVEETSVRYKFLEVFGKPNQLLESIEEAGNHQFFFLDIEIKGEEKKGMEIAKEIRAR
DPYAVIVFVTTHSEFMPVTYRYRVSALDFIDKGLEDSDFQKAVSDVLVHAFENIDHTIAENSFIYKTETAHIQVPFSDIL
YFETSSTIHKVILKTKTGQTEFYGKVSDIAKADERLYQAHRSCVVNPLNITRLDRTNHIAYFENGDSCFVSRLKQKKLSD
LLGND

Nucleotide


Download         Length: 738 bp        

>NTDB_id=256949 CVO91_RS12200 WP_002941995.1 2414628..2415365(-) (comE/blpR) [Streptococcus suis strain CZ130302]
ATGCTTAATATTTTTGTATTAGAAGATGATTTTTTTCAGCAGAGTAGGCTAGAAAATGCTATTAGGCGGTGTGTTGAAGA
AACGTCAGTAAGGTATAAATTCCTAGAAGTTTTTGGTAAACCAAATCAATTATTGGAATCAATCGAGGAAGCGGGGAATC
ACCAATTTTTCTTTTTAGATATTGAAATAAAAGGCGAAGAAAAGAAAGGCATGGAAATCGCTAAAGAAATCCGTGCTCGC
GATCCCTATGCTGTTATTGTCTTTGTAACAACTCACTCAGAATTTATGCCGGTAACGTATCGTTATCGGGTTTCTGCTTT
AGATTTTATAGATAAAGGCCTGGAGGATAGTGACTTTCAAAAGGCCGTATCAGATGTGTTAGTGCATGCTTTTGAAAATA
TTGATCATACTATAGCTGAAAATTCTTTTATATACAAAACTGAAACTGCTCATATTCAAGTCCCTTTTAGTGACATCCTT
TATTTTGAAACATCATCAACAATACATAAAGTTATTTTAAAAACCAAAACAGGTCAGACTGAGTTTTACGGGAAAGTATC
CGATATAGCGAAAGCAGATGAACGACTTTACCAGGCACATCGTTCTTGTGTAGTGAATCCATTAAATATAACGAGATTGG
ACAGAACAAACCATATTGCCTATTTTGAGAATGGAGATTCTTGTTTTGTTTCTCGTTTGAAGCAGAAGAAACTTTCAGAT
TTGTTGGGGAATGATTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.694

100

0.547
  comE/comE1 Streptococcus equinus JB1

50

97.143

0.486
  comE/comE2 Streptococcus equinus JB1

40.984

99.592

0.408
  comE/comE2 Streptococcus gordonii strain NCTC7865

38.776

100

0.388
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

38.776

100

0.388
  comE Streptococcus infantis strain Atu-4

38.306

100

0.388
  comE Streptococcus mitis NCTC 12261

38.306

100

0.388
  comE Streptococcus mitis SK321

38.306

100

0.388
  comE Streptococcus pneumoniae Rx1

38.306

100

0.388
  comE Streptococcus pneumoniae D39

38.306

100

0.388
  comE Streptococcus pneumoniae R6

38.306

100

0.388
  comE Streptococcus pneumoniae TIGR4

38.306

100

0.388

Multiple sequence alignment