Detailed information
Bioinformatically predicted
Overview
| Name | comGC/cglC | Type | Machinery gene |
| Locus tag | QMA0248_RS00845 | Genome accession | NZ_CP022392 |
| Coordinates | 136388..136714 (+) | Length | 108 a.a. |
| NCBI ID | WP_003098806.1 | Uniprot ID | - |
| Organism | Streptococcus iniae strain QMA0248 | ||
| Function | dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 87560..156942 | 136388..136714 | within | 0 |
Gene organization within MGE regions
Location: 87560..156942
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMA0248_RS00605 (QMA0248_0126) | - | 87909..88103 (-) | 195 | WP_000562208.1 | DUF3173 family protein | - |
| QMA0248_RS00610 (QMA0248_0127) | - | 88172..89518 (-) | 1347 | WP_003098677.1 | Rep family protein | - |
| QMA0248_RS00615 (QMA0248_0128) | - | 89868..90227 (-) | 360 | WP_003098679.1 | hypothetical protein | - |
| QMA0248_RS00625 (QMA0248_0129) | - | 90837..91244 (+) | 408 | WP_003098684.1 | helix-turn-helix domain-containing protein | - |
| QMA0248_RS00630 (QMA0248_0130) | - | 91338..91532 (+) | 195 | WP_016355751.1 | hypothetical protein | - |
| QMA0248_RS00635 | - | 91529..91837 (-) | 309 | Protein_89 | RNA polymerase sigma factor | - |
| QMA0248_RS00645 (QMA0248_0132) | - | 92603..93556 (-) | 954 | WP_003098714.1 | IS30 family transposase | - |
| QMA0248_RS10510 | - | 93674..93946 (+) | 273 | Protein_91 | collagen binding domain-containing protein | - |
| QMA0248_RS10515 (QMA0248_0133) | - | 94076..95380 (+) | 1305 | WP_411198206.1 | Cna B-type domain-containing protein | - |
| QMA0248_RS00660 (QMA0248_0134) | - | 95549..96724 (+) | 1176 | WP_003099060.1 | IS256 family transposase | - |
| QMA0248_RS10520 | - | 96985..97185 (+) | 201 | WP_080768722.1 | ATP-binding cassette domain-containing protein | - |
| QMA0248_RS00675 (QMA0248_0135) | - | 97721..98488 (+) | 768 | WP_037583616.1 | ABC transporter permease subunit | - |
| QMA0248_RS00680 (QMA0248_0136) | - | 98807..99829 (+) | 1023 | WP_003098721.1 | IS30 family transposase | - |
| QMA0248_RS10390 | - | 100085..100171 (+) | 87 | Protein_97 | ABC transporter ATP-binding protein | - |
| QMA0248_RS00690 (QMA0248_0137) | - | 100168..100398 (+) | 231 | Protein_98 | hypothetical protein | - |
| QMA0248_RS00700 (QMA0248_0140) | - | 101624..101887 (+) | 264 | Protein_100 | hypothetical protein | - |
| QMA0248_RS00705 (QMA0248_0141) | - | 102102..102551 (+) | 450 | WP_016355755.1 | pyridoxamine 5'-phosphate oxidase family protein | - |
| QMA0248_RS00710 (QMA0248_0142) | - | 102653..103066 (+) | 414 | WP_003098726.1 | DUF1722 domain-containing protein | - |
| QMA0248_RS00715 (QMA0248_0143) | adhP | 103126..104145 (-) | 1020 | WP_003098727.1 | alcohol dehydrogenase AdhP | - |
| QMA0248_RS00720 | - | 104945..105298 (+) | 354 | WP_003098729.1 | alpha/beta fold hydrolase | - |
| QMA0248_RS00725 | - | 105335..105733 (+) | 399 | WP_016355758.1 | hypothetical protein | - |
| QMA0248_RS00730 (QMA0248_0147) | - | 105846..106376 (+) | 531 | WP_003098733.1 | GNAT family N-acetyltransferase | - |
| QMA0248_RS00735 | - | 106596..107218 (+) | 623 | Protein_107 | MFS transporter | - |
| QMA0248_RS00740 (QMA0248_0149) | - | 107490..108714 (+) | 1225 | Protein_108 | peptidoglycan bridge formation glycyltransferase FemA/FemB family protein | - |
| QMA0248_RS00745 (QMA0248_0151) | - | 108795..109325 (+) | 531 | WP_003098764.1 | NUDIX hydrolase | - |
| QMA0248_RS00750 (QMA0248_0152) | - | 109336..109959 (+) | 624 | WP_003098766.1 | tetratricopeptide repeat protein | - |
| QMA0248_RS00755 (QMA0248_0153) | - | 110369..111268 (+) | 900 | WP_016355761.1 | prenyltransferase | - |
| QMA0248_RS00760 (QMA0248_0154) | - | 111281..112492 (+) | 1212 | WP_003098771.1 | NAD(P)/FAD-dependent oxidoreductase | - |
| QMA0248_RS00765 (QMA0248_0155) | - | 112579..114006 (+) | 1428 | WP_089180046.1 | cytochrome ubiquinol oxidase subunit I | - |
| QMA0248_RS00770 (QMA0248_0156) | cydB | 114008..115027 (+) | 1020 | WP_003098776.1 | cytochrome d ubiquinol oxidase subunit II | - |
| QMA0248_RS00775 (QMA0248_0157) | cydD | 115027..116745 (+) | 1719 | WP_016355762.1 | thiol reductant ABC exporter subunit CydD | - |
| QMA0248_RS00780 (QMA0248_0158) | cydC | 116738..118483 (+) | 1746 | WP_089180047.1 | thiol reductant ABC exporter subunit CydC | - |
| QMA0248_RS00785 (QMA0248_0159) | - | 118617..119594 (-) | 978 | WP_003098781.1 | polyprenyl synthetase family protein | - |
| QMA0248_RS00790 (QMA0248_0160) | ispE | 119795..120646 (+) | 852 | WP_003098783.1 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | - |
| QMA0248_RS00795 (QMA0248_0161) | - | 120714..121157 (+) | 444 | WP_003098785.1 | zinc-dependent MarR family transcriptional regulator | - |
| QMA0248_RS00800 (QMA0248_0162) | - | 121162..121860 (+) | 699 | WP_003098787.1 | metal ABC transporter ATP-binding protein | - |
| QMA0248_RS00805 (QMA0248_0163) | - | 121863..122678 (+) | 816 | WP_003098790.1 | metal ABC transporter permease | - |
| QMA0248_RS00810 (QMA0248_0164) | tyrS | 122723..123979 (-) | 1257 | WP_003098791.1 | tyrosine--tRNA ligase | - |
| QMA0248_RS00815 (QMA0248_0165) | pbp1b | 124073..126379 (+) | 2307 | WP_031239175.1 | penicillin-binding protein PBP1B | - |
| QMA0248_RS00820 (QMA0248_0166) | rpoB | 126641..130204 (+) | 3564 | WP_089180048.1 | DNA-directed RNA polymerase subunit beta | - |
| QMA0248_RS00825 (QMA0248_0167) | rpoC | 130302..133934 (+) | 3633 | WP_089180049.1 | DNA-directed RNA polymerase subunit beta' | - |
| QMA0248_RS00830 (QMA0248_0168) | - | 134053..134418 (+) | 366 | WP_003098799.1 | DUF1033 family protein | - |
| QMA0248_RS00835 (QMA0248_0169) | comYA | 134479..135420 (+) | 942 | WP_003098801.1 | competence type IV pilus ATPase ComGA | Machinery gene |
| QMA0248_RS00840 (QMA0248_0170) | comYB | 135371..136387 (+) | 1017 | WP_259458648.1 | competence type IV pilus assembly protein ComGB | Machinery gene |
| QMA0248_RS00845 (QMA0248_0171) | comGC/cglC | 136388..136714 (+) | 327 | WP_003098806.1 | competence type IV pilus major pilin ComGC | Machinery gene |
| QMA0248_RS10465 (QMA0248_0172) | comGD | 136674..137102 (+) | 429 | WP_003098807.1 | competence type IV pilus minor pilin ComGD | - |
| QMA0248_RS00855 (QMA0248_2083) | comGE | 137074..137367 (+) | 294 | WP_031239176.1 | competence type IV pilus minor pilin ComGE | - |
| QMA0248_RS00860 (QMA0248_0173) | comYF | 137327..137776 (+) | 450 | WP_119773875.1 | competence type IV pilus minor pilin ComGF | Machinery gene |
| QMA0248_RS00865 (QMA0248_0174) | comGG | 137766..138119 (+) | 354 | WP_003098812.1 | competence type IV pilus minor pilin ComGG | - |
| QMA0248_RS00870 (QMA0248_0175) | comYH | 138181..139137 (+) | 957 | WP_003098815.1 | class I SAM-dependent methyltransferase | Machinery gene |
| QMA0248_RS00875 (QMA0248_0176) | - | 139194..140390 (+) | 1197 | WP_003098816.1 | acetate kinase | - |
| QMA0248_RS00880 (QMA0248_0177) | - | 140513..140716 (+) | 204 | WP_003098819.1 | helix-turn-helix transcriptional regulator | - |
| QMA0248_RS00885 (QMA0248_0178) | - | 140729..141181 (+) | 453 | WP_003098820.1 | hypothetical protein | - |
| QMA0248_RS00890 (QMA0248_0179) | - | 141191..141847 (+) | 657 | WP_003098822.1 | CPBP family intramembrane glutamic endopeptidase | - |
| QMA0248_RS00895 (QMA0248_0180) | proC | 141881..142651 (-) | 771 | WP_003098824.1 | pyrroline-5-carboxylate reductase | - |
| QMA0248_RS00900 (QMA0248_0181) | pepA | 142675..143742 (-) | 1068 | WP_003098826.1 | glutamyl aminopeptidase | - |
| QMA0248_RS00905 (QMA0248_2084) | - | 143883..144167 (+) | 285 | WP_003098828.1 | DUF4651 domain-containing protein | - |
| QMA0248_RS00910 (QMA0248_0182) | - | 144164..144481 (+) | 318 | WP_003098830.1 | thioredoxin family protein | - |
| QMA0248_RS00915 (QMA0248_0183) | ytpR | 144498..145124 (+) | 627 | WP_003098832.1 | YtpR family tRNA-binding protein | - |
| QMA0248_RS00920 (QMA0248_0184) | - | 145162..145572 (-) | 411 | WP_003098834.1 | GNAT family N-acetyltransferase | - |
| QMA0248_RS00925 (QMA0248_0185) | ssbA | 145644..146039 (+) | 396 | WP_003098836.1 | single-stranded DNA-binding protein | Machinery gene |
| QMA0248_RS00930 (QMA0248_0186) | - | 146513..147475 (+) | 963 | WP_003098839.1 | ABC transporter substrate-binding protein | - |
| QMA0248_RS00935 (QMA0248_0187) | - | 147489..148463 (+) | 975 | WP_089180051.1 | ABC transporter substrate-binding protein | - |
| QMA0248_RS00940 (QMA0248_0188) | - | 148473..149357 (+) | 885 | WP_003098842.1 | ABC transporter permease | - |
| QMA0248_RS00945 (QMA0248_0189) | - | 149366..150169 (+) | 804 | WP_003098843.1 | ABC transporter ATP-binding protein | - |
| QMA0248_RS00950 (QMA0248_0190) | - | 150230..150874 (-) | 645 | WP_003098844.1 | deoxynucleoside kinase | - |
| QMA0248_RS00955 (QMA0248_0191) | dusB | 150892..151869 (-) | 978 | WP_003098845.1 | tRNA dihydrouridine synthase DusB | - |
| QMA0248_RS00960 (QMA0248_0192) | hslO | 151856..152728 (-) | 873 | WP_003098846.1 | Hsp33 family molecular chaperone HslO | - |
| QMA0248_RS00965 (QMA0248_0193) | - | 153079..156663 (+) | 3585 | WP_003098847.1 | accessory Sec-dependent serine-rich glycoprotein adhesin | - |
Sequence
Protein
Download Length: 108 a.a. Molecular weight: 12153.19 Da Isoelectric Point: 10.0312
>NTDB_id=238972 QMA0248_RS00845 WP_003098806.1 136388..136714(+) (comGC/cglC) [Streptococcus iniae strain QMA0248]
MKTKCKQLKESRTKAFTLLEMLIVLLIISVLMLLFIPNLSKQKDKVTDAGNAAVVKIVENQAELYELTEGGKASLAQLQS
KGHITDKQAKAYQDYYAKNSDKHRQVNN
MKTKCKQLKESRTKAFTLLEMLIVLLIISVLMLLFIPNLSKQKDKVTDAGNAAVVKIVENQAELYELTEGGKASLAQLQS
KGHITDKQAKAYQDYYAKNSDKHRQVNN
Nucleotide
Download Length: 327 bp
>NTDB_id=238972 QMA0248_RS00845 WP_003098806.1 136388..136714(+) (comGC/cglC) [Streptococcus iniae strain QMA0248]
ATGAAAACAAAATGTAAACAACTAAAAGAAAGCCGTACTAAAGCTTTCACACTTCTAGAAATGTTGATTGTTTTGCTAAT
TATTAGTGTTCTTATGCTACTGTTTATTCCGAATTTAAGTAAGCAAAAAGATAAGGTTACAGATGCTGGTAATGCTGCAG
TGGTTAAAATTGTTGAAAATCAGGCGGAACTATATGAATTAACGGAAGGTGGGAAAGCAAGCCTCGCTCAACTCCAATCA
AAAGGTCATATTACAGACAAACAAGCGAAGGCTTATCAGGATTATTATGCCAAAAACAGTGACAAGCATAGACAAGTTAA
CAACTAG
ATGAAAACAAAATGTAAACAACTAAAAGAAAGCCGTACTAAAGCTTTCACACTTCTAGAAATGTTGATTGTTTTGCTAAT
TATTAGTGTTCTTATGCTACTGTTTATTCCGAATTTAAGTAAGCAAAAAGATAAGGTTACAGATGCTGGTAATGCTGCAG
TGGTTAAAATTGTTGAAAATCAGGCGGAACTATATGAATTAACGGAAGGTGGGAAAGCAAGCCTCGCTCAACTCCAATCA
AAAGGTCATATTACAGACAAACAAGCGAAGGCTTATCAGGATTATTATGCCAAAAACAGTGACAAGCATAGACAAGTTAA
CAACTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comGC/cglC | Streptococcus pneumoniae TIGR4 |
59.259 |
100 |
0.593 |
| comGC/cglC | Streptococcus pneumoniae D39 |
59.259 |
100 |
0.593 |
| comGC/cglC | Streptococcus pneumoniae R6 |
59.259 |
100 |
0.593 |
| comGC/cglC | Streptococcus pneumoniae Rx1 |
59.259 |
100 |
0.593 |
| comGC/cglC | Streptococcus mitis SK321 |
63.366 |
93.519 |
0.593 |
| comYC | Streptococcus gordonii str. Challis substr. CH1 |
61.165 |
95.37 |
0.583 |
| comYC | Streptococcus mutans UA140 |
59.223 |
95.37 |
0.565 |
| comYC | Streptococcus mutans UA159 |
59.223 |
95.37 |
0.565 |
| comGC/cglC | Streptococcus mitis NCTC 12261 |
64.835 |
84.259 |
0.546 |
| comGC | Lactococcus lactis subsp. cremoris KW2 |
51.376 |
100 |
0.519 |
| comYC | Streptococcus suis isolate S10 |
60.92 |
80.556 |
0.491 |