Detailed information NTG0022559

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SPYM18_RS02330
• Genome accession: NC_003485
• Coordinates: 428266..429015 (+)
• Length: 249 a.a.
• NCBI ID: WP_002992578.1
• Uniprot ID: Q8P262
• Organism: Streptococcus pyogenes MGAS8232
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 423266..434015

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYM18_RS10740	-	423686..423997 (+)	312	WP_225793061.1	CPBP family intramembrane glutamic endopeptidase	-
SPYM18_RS10610	-	424082..424210 (+)	129	WP_002994583.1	hypothetical protein	-
SPYM18_RS02300	-	424608..424835 (+)	228	WP_028797129.1	Blp family class II bacteriocin	-
SPYM18_RS02305	-	424884..425201 (+)	318	WP_002994587.1	hypothetical protein	-
SPYM18_RS10450	-	425321..426406 (+)	1086	Protein_415	IS3 family transposase	-
SPYM18_RS02325 (spyM18_0536)	-	426620..428018 (+)	1399	Protein_416	IS1182 family transposase	-
SPYM18_RS02330 (spyM18_0538)	comE/blpR	428266..429015 (+)	750	WP_002992578.1	response regulator transcription factor	Regulator
SPYM18_RS02335 (spyM18_0539)	-	429016..430350 (+)	1335	WP_011017461.1	sensor histidine kinase	-
SPYM18_RS09785 (spyM18_0540)	-	430498..430623 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SPYM18_RS02340	-	430700..432063 (-)	1364	Protein_420	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29191.55 Da
• Isoelectric Point: 5.8302

>NTDB_id=22559 SPYM18_RS02330 WP_002992578.1 428266..429015(+) (comE/blpR) [Streptococcus pyogenes MGAS8232]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFINVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=22559 SPYM18_RS02330 WP_002992578.1 428266..429015(+) (comE/blpR) [Streptococcus pyogenes MGAS8232]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTATTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (3-119)

3D structure

• AlphaFold DB: Q8P262

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.508	97.992	0.534
comE/comE2	Streptococcus gordonii strain NCTC7865	40.873	100	0.414
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.873	100	0.414
comE/comE1	Streptococcus equinus JB1	42.017	95.582	0.402
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	38.8	100	0.39
comE	Streptococcus mitis SK321	38.8	100	0.39
comE	Streptococcus pneumoniae TIGR4	38.4	100	0.386
comE	Streptococcus pneumoniae Rx1	38.4	100	0.386
comE	Streptococcus pneumoniae D39	38.4	100	0.386
comE	Streptococcus pneumoniae R6	38.4	100	0.386
comE	Streptococcus infantis strain Atu-4	38.095	100	0.386