Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   A6J85_RS01910 Genome accession   NZ_CP020450
Coordinates   383824..384558 (-) Length   244 a.a.
NCBI ID   WP_048778123.1    Uniprot ID   -
Organism   Streptococcus gordonii strain FDAARGOS_257     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 368626..404461 383824..384558 within 0


Gene organization within MGE regions


Location: 368626..404461
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J85_RS01830 (A6J85_01825) - 368626..369174 (-) 549 WP_082307779.1 DUF6609 family protein -
  A6J85_RS01835 (A6J85_01830) - 369463..369915 (+) 453 WP_082307200.1 DUF3290 family protein -
  A6J85_RS01840 (A6J85_01835) - 369915..370544 (+) 630 WP_082307201.1 DUF421 domain-containing protein -
  A6J85_RS01845 (A6J85_01840) - 370726..370929 (+) 204 WP_008808393.1 CsbD family protein -
  A6J85_RS01850 (A6J85_01845) - 371281..372000 (-) 720 WP_008808392.1 hypothetical protein -
  A6J85_RS01855 (A6J85_01850) - 371993..372673 (-) 681 WP_061601552.1 ATP-binding cassette domain-containing protein -
  A6J85_RS01860 (A6J85_01855) - 372730..375135 (-) 2406 WP_061601553.1 hypothetical protein -
  A6J85_RS01865 (A6J85_01865) - 375135..376211 (-) 1077 WP_048778144.1 M20/M25/M40 family metallo-hydrolase -
  A6J85_RS01870 (A6J85_01870) - 376231..376974 (-) 744 WP_048778142.1 hypothetical protein -
  A6J85_RS01875 (A6J85_01875) - 376975..377793 (-) 819 WP_048778139.1 nitroreductase family protein -
  A6J85_RS01880 (A6J85_01880) - 377780..378625 (-) 846 WP_048778137.1 thiopeptide-type bacteriocin biosynthesis protein -
  A6J85_RS01885 (A6J85_01885) - 378636..380309 (-) 1674 WP_061601554.1 YcaO-like family protein -
  A6J85_RS01890 (A6J85_10935) - 380324..380971 (-) 648 WP_048778130.1 hypothetical protein -
  A6J85_RS01895 (A6J85_01895) - 380949..381887 (-) 939 WP_048778129.1 hypothetical protein -
  A6J85_RS01900 (A6J85_10940) - 381958..382128 (-) 171 WP_103344441.1 thiopeptide-type bacteriocin -
  A6J85_RS01905 (A6J85_01900) - 382483..383811 (-) 1329 WP_048778126.1 GHKL domain-containing protein -
  A6J85_RS01910 (A6J85_01905) comE/blpR 383824..384558 (-) 735 WP_048778123.1 LytTR family DNA-binding domain-containing protein Regulator
  A6J85_RS11250 (A6J85_01915) - 385228..385359 (+) 132 Protein_365 site-specific integrase -
  A6J85_RS01925 (A6J85_01920) - 385738..386109 (-) 372 WP_046165031.1 type II toxin-antitoxin system death-on-curing family toxin -
  A6J85_RS01930 (A6J85_01925) - 386106..386363 (-) 258 WP_046165030.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
  A6J85_RS01940 (A6J85_01930) pezT 386631..387398 (-) 768 WP_046165029.1 type II toxin-antitoxin system toxin PezT -
  A6J85_RS01945 (A6J85_01935) pezA 387398..387874 (-) 477 WP_061601558.1 type II toxin-antitoxin system antitoxin PezA -
  A6J85_RS11155 - 388265..388546 (+) 282 WP_231083267.1 SPASM domain-containing protein -
  A6J85_RS01955 (A6J85_01945) - 388530..390047 (+) 1518 WP_061601559.1 ABC transporter ATP-binding protein -
  A6J85_RS01965 (A6J85_01955) - 390765..391085 (-) 321 WP_002893753.1 hypothetical protein -
  A6J85_RS11205 (A6J85_10950) - 391119..391253 (-) 135 WP_023024363.1 hypothetical protein -
  A6J85_RS01975 (A6J85_01960) cadX 391297..391635 (-) 339 WP_000711078.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
  A6J85_RS01980 (A6J85_01965) - 391647..392261 (-) 615 WP_002911684.1 CadD family cadmium resistance transporter -
  A6J85_RS01985 (A6J85_01970) - 392561..394624 (-) 2064 WP_002893754.1 heavy metal translocating P-type ATPase -
  A6J85_RS01990 (A6J85_01975) - 394626..394904 (-) 279 WP_002893755.1 DUF6110 family protein -
  A6J85_RS01995 (A6J85_01980) - 395085..395675 (-) 591 Protein_378 transposase -
  A6J85_RS02005 (A6J85_01990) - 396163..397212 (-) 1050 Protein_379 DUF389 domain-containing protein -
  A6J85_RS02010 (A6J85_01995) - 397209..397532 (-) 324 WP_001253404.1 potassium channel family protein -
  A6J85_RS02015 (A6J85_02000) - 397546..397887 (-) 342 WP_000397556.1 hypothetical protein -
  A6J85_RS02020 (A6J85_02005) - 397812..398114 (-) 303 WP_004240734.1 TMEM175 family protein -
  A6J85_RS11070 - 398827..398994 (-) 168 WP_020992799.1 hypothetical protein -
  A6J85_RS02030 (A6J85_02010) - 399008..399661 (-) 654 WP_000677415.1 ABC-2 transporter permease -
  A6J85_RS02035 (A6J85_02015) - 399642..400499 (-) 858 WP_008808388.1 ABC transporter ATP-binding protein -
  A6J85_RS02040 (A6J85_02020) - 400512..401024 (-) 513 WP_020992800.1 hypothetical protein -
  A6J85_RS02045 (A6J85_02025) - 401036..401503 (-) 468 WP_008808387.1 stage II sporulation protein M -
  A6J85_RS02050 (A6J85_02030) - 401591..401869 (-) 279 WP_008808386.1 class IIc cyclic bacteriocin -
  A6J85_RS02055 (A6J85_02035) - 402314..403174 (-) 861 WP_046165026.1 helix-turn-helix domain-containing protein -
  A6J85_RS02060 (A6J85_02040) - 403291..403863 (-) 573 WP_008808384.1 helix-turn-helix transcriptional regulator -
  A6J85_RS02065 (A6J85_02045) - 404018..404461 (+) 444 WP_046165025.1 hypothetical protein -

Sequence

Protein


Download         Length: 244 a.a.        Molecular weight: 28626.00 Da        Isoelectric Point: 6.6144

>NTDB_id=223156 A6J85_RS01910 WP_048778123.1 383824..384558(-) (comE/blpR) [Streptococcus gordonii strain FDAARGOS_257]
MLNIYVLEDELLQQSRIETIIYKVIKDENLKINKFDIFGRPSQLLAEITERGSHQLFFLDIEIKDEEKKGLELAYQIRKL
DPNATIVFVTTHSEFMPLTFRYKVSALDFIDKALGDLHFYERVKSAIEYTLEKNGSTVAHDSFKFETSLSRVQVPFNKIL
YFETSPTVHKVIMHTIDERLEFYAGISEIEKTDNRLYRCHKSFVVNPENISKIDKENKLILFENGESCLVSKTKLKKLKE
RLDF

Nucleotide


Download         Length: 735 bp        

>NTDB_id=223156 A6J85_RS01910 WP_048778123.1 383824..384558(-) (comE/blpR) [Streptococcus gordonii strain FDAARGOS_257]
ATGCTTAACATTTATGTTTTGGAAGACGAATTACTACAACAGTCTCGCATAGAGACTATTATTTATAAGGTGATAAAAGA
TGAAAATTTAAAAATTAATAAGTTTGATATTTTTGGAAGGCCATCTCAATTATTAGCAGAGATAACTGAGAGAGGCTCTC
ATCAGTTATTTTTTTTAGATATTGAGATCAAGGATGAAGAGAAAAAAGGATTGGAGCTTGCTTATCAAATTAGAAAGCTC
GATCCCAATGCAACTATTGTCTTTGTGACTACCCATTCTGAGTTTATGCCATTAACATTTAGATATAAAGTTAGTGCTTT
GGATTTTATTGATAAGGCACTTGGTGATCTTCATTTTTATGAAAGAGTAAAATCAGCGATTGAATATACATTGGAAAAAA
ATGGAAGTACTGTTGCTCATGATTCTTTTAAATTCGAAACATCACTATCTCGTGTCCAAGTTCCATTTAATAAAATTCTT
TATTTTGAAACATCGCCTACTGTGCATAAGGTTATTATGCATACGATAGATGAAAGATTAGAATTTTATGCTGGAATTTC
TGAGATTGAAAAAACGGATAATAGGTTATACAGATGTCACAAGTCATTTGTCGTAAATCCTGAAAACATTAGTAAGATTG
ATAAGGAAAATAAGCTAATTCTATTTGAAAATGGAGAAAGTTGCTTAGTTTCTAAGACTAAATTAAAGAAACTCAAGGAA
AGGTTAGATTTTTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(5-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.372

99.18

0.549
  comE/comE1 Streptococcus equinus JB1

44.958

97.541

0.439
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.891

100

0.414
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.891

100

0.414
  comE/comE2 Streptococcus equinus JB1

39.095

99.59

0.389
  comE Streptococcus mitis NCTC 12261

37.5

100

0.381
  comE Streptococcus pneumoniae D39

37.5

100

0.381
  comE Streptococcus pneumoniae Rx1

37.5

100

0.381
  comE Streptococcus pneumoniae R6

37.5

100

0.381
  comE Streptococcus pneumoniae TIGR4

37.5

100

0.381
  comE Streptococcus mitis SK321

37.5

100

0.381
  comE Streptococcus infantis strain Atu-4

35.887

100

0.365

Multiple sequence alignment