Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SPYM18_RS02330 Genome accession   NC_003485
Coordinates   428266..429015 (+) Length   249 a.a.
NCBI ID   WP_002992578.1    Uniprot ID   A0AAE9QYY6
Organism   Streptococcus pyogenes MGAS8232     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 425582..427825 428266..429015 flank 441


Gene organization within MGE regions


Location: 425582..429015
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYM18_RS02325 (spyM18_0536) - 426620..428018 (+) 1399 Protein_416 IS1182 family transposase -
  SPYM18_RS02330 (spyM18_0538) comE/blpR 428266..429015 (+) 750 WP_002992578.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29191.55 Da        Isoelectric Point: 5.8302

>NTDB_id=21928 SPYM18_RS02330 WP_002992578.1 428266..429015(+) (comE/blpR) [Streptococcus pyogenes MGAS8232]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFINVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRSERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide


Download         Length: 750 bp        

>NTDB_id=21928 SPYM18_RS02330 WP_002992578.1 428266..429015(+) (comE/blpR) [Streptococcus pyogenes MGAS8232]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTATTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GATCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(150-239)

Response regulator receiver domain (Response_reg)

(3-119)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.508

97.992

0.534
  comE/comE2 Streptococcus gordonii strain NCTC7865

40.873

100

0.414
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

40.873

100

0.414
  comE/comE1 Streptococcus equinus JB1

42.017

95.582

0.402
  comE/comE2 Streptococcus equinus JB1

40.574

97.992

0.398
  comE Streptococcus mitis NCTC 12261

38.8

100

0.39
  comE Streptococcus mitis SK321

38.8

100

0.39
  comE Streptococcus pneumoniae TIGR4

38.4

100

0.386
  comE Streptococcus pneumoniae Rx1

38.4

100

0.386
  comE Streptococcus pneumoniae D39

38.4

100

0.386
  comE Streptococcus pneumoniae R6

38.4

100

0.386
  comE Streptococcus infantis strain Atu-4

38.095

100

0.386

Multiple sequence alignment