Detailed information NTG0214735

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: BWQ98_RS10960
• Genome accession: NZ_CP019299
• Coordinates: 2032747..2033499 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain HKU1-14
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2027747..2038499

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWQ98_RS11745 (BWQ98_10965)	-	2030181..2031834 (-)	1654	Protein_2029	YhgE/Pip domain-containing protein	-
BWQ98_RS10945 (BWQ98_10970)	-	2031962..2032504 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
BWQ98_RS10960 (BWQ98_10985)	comE	2032747..2033499 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
BWQ98_RS10965 (BWQ98_10990)	comD/comD1	2033496..2034821 (-)	1326	WP_127245098.1	competence system sensor histidine kinase ComD	Regulator
BWQ98_RS10970 (BWQ98_10995)	comC/comC1	2034842..2034967 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
BWQ98_RS10980 (BWQ98_11005)	rlmH	2035250..2035729 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
BWQ98_RS10985 (BWQ98_11010)	htrA	2035912..2037093 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
BWQ98_RS10990 (BWQ98_11015)	spo0J	2037151..2037909 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=214735 BWQ98_RS10960 WP_000866065.1 2032747..2033499(-) (comE) [Streptococcus pneumoniae strain HKU1-14]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=214735 BWQ98_RS10960 WP_000866065.1 2032747..2033499(-) (comE) [Streptococcus pneumoniae strain HKU1-14]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408