Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   BWQ98_RS10965 Genome accession   NZ_CP019299
Coordinates   2033496..2034821 (-) Length   441 a.a.
NCBI ID   WP_127245098.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain HKU1-14     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2028496..2039821
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BWQ98_RS11745 (BWQ98_10965) - 2030181..2031834 (-) 1654 Protein_2029 YhgE/Pip domain-containing protein -
  BWQ98_RS10945 (BWQ98_10970) - 2031962..2032504 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  BWQ98_RS10960 (BWQ98_10985) comE 2032747..2033499 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  BWQ98_RS10965 (BWQ98_10990) comD/comD1 2033496..2034821 (-) 1326 WP_127245098.1 competence system sensor histidine kinase ComD Regulator
  BWQ98_RS10970 (BWQ98_10995) comC/comC1 2034842..2034967 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  BWQ98_RS10980 (BWQ98_11005) rlmH 2035250..2035729 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  BWQ98_RS10985 (BWQ98_11010) htrA 2035912..2037093 (+) 1182 WP_000681597.1 trypsin-like peptidase domain-containing protein Regulator
  BWQ98_RS10990 (BWQ98_11015) spo0J 2037151..2037909 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51188.61 Da        Isoelectric Point: 6.6396

>NTDB_id=214736 BWQ98_RS10965 WP_127245098.1 2033496..2034821(-) (comD/comD1) [Streptococcus pneumoniae strain HKU1-14]
MDLFGFGTVIVHFLIISHSYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIATFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=214736 BWQ98_RS10965 WP_127245098.1 2033496..2034821(-) (comD/comD1) [Streptococcus pneumoniae strain HKU1-14]
ATGGATTTATTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGCTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCCTATATTCCTATTTTCGATGGATAAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACGAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

99.093

100

0.991
  comD/comD1 Streptococcus pneumoniae D39

99.093

100

0.991
  comD/comD1 Streptococcus pneumoniae R6

99.093

100

0.991
  comD/comD2 Streptococcus pneumoniae TIGR4

96.372

100

0.964
  comD Streptococcus mitis SK321

92.517

100

0.925
  comD Streptococcus mitis NCTC 12261

86.395

100

0.864
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.734

85.261

0.424
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.261

0.422

Multiple sequence alignment