Detailed information NTG0206838

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: BSR19_RS02375
• Genome accession: NZ_CP018187
• Coordinates: 458089..458823 (+)
• Length: 244 a.a.
• NCBI ID: WP_060973247.1
• Uniprot ID: A0AB37D8J7
• Organism: Streptococcus salivarius strain ICDC2
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 453089..463823

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BSR19_RS02360 (BSR19_02360)	-	453505..456087 (+)	2583	WP_060973380.1	SH3 domain-containing protein	-
BSR19_RS02365 (BSR19_02365)	-	456289..457041 (+)	753	WP_060973375.1	LytR/AlgR family response regulator transcription factor	-
BSR19_RS02370 (BSR19_02370)	-	457176..457841 (+)	666	WP_156246406.1	DUF6287 domain-containing protein	-
BSR19_RS02375 (BSR19_02375)	comE/blpR	458089..458823 (+)	735	WP_060973247.1	response regulator transcription factor	Regulator
BSR19_RS11560	-	458820..459104 (+)	285	WP_231605975.1	hypothetical protein	-
BSR19_RS11565	-	459284..460114 (+)	831	WP_231605976.1	sensor histidine kinase	-
BSR19_RS02385 (BSR19_02385)	-	460212..460778 (+)	567	WP_156246408.1	transcriptional regulator	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28534.87 Da
• Isoelectric Point: 6.3907

>NTDB_id=206838 BSR19_RS02375 WP_060973247.1 458089..458823(+) (comE/blpR) [Streptococcus salivarius strain ICDC2]
MLDIYVLEDHFIQQNRIEEVIHTILKKNNIKVGDFEVFDKPNQLLESVTERGSHQLFFLDIQIKDDTKKGLEVAKQIRKN
DPYANIVFFTTHSEYLPLTFQYQLAALDFIDKSLEGEDFQKRVESIILLTCKKIQSQNPEDAFRIENVKTVIQVPFHDIL
YLETSDIVHKVILYTKEEQIEFYGSLSQIEKSDPRLFKCHKSFLVNPENIIKLDKSTGTVYFENGGVCYVSKLKLKKLIE
RIGR

Nucleotide

• Length: 735 bp

>NTDB_id=206838 BSR19_RS02375 WP_060973247.1 458089..458823(+) (comE/blpR) [Streptococcus salivarius strain ICDC2]
ATGCTTGACATCTATGTTTTAGAGGATCATTTTATCCAACAAAATCGTATTGAAGAGGTTATTCATACGATTCTTAAGAA
AAATAACATTAAAGTGGGTGACTTTGAGGTTTTTGACAAACCCAATCAACTGTTAGAGTCTGTTACTGAGAGAGGATCTC
ATCAGCTCTTTTTCCTGGACATTCAGATTAAAGACGATACTAAAAAAGGTTTAGAAGTGGCTAAGCAGATTCGCAAGAAC
GACCCCTATGCCAATATTGTTTTTTTCACGACTCATTCAGAGTATCTTCCCTTAACTTTTCAATACCAACTGGCAGCTCT
AGACTTTATTGATAAGTCTTTGGAGGGAGAGGACTTTCAAAAGCGTGTGGAAAGTATTATCTTATTAACCTGCAAAAAGA
TACAGAGTCAGAATCCAGAAGACGCTTTTCGGATTGAGAATGTTAAGACCGTTATTCAGGTTCCCTTTCATGATATCTTG
TACCTTGAGACCTCGGATATCGTTCATAAGGTTATCCTTTATACTAAAGAGGAGCAGATTGAGTTTTATGGCAGTCTCTC
TCAAATTGAAAAGAGCGACCCTAGACTGTTTAAATGTCATAAGTCCTTCCTAGTTAATCCAGAAAATATCATCAAATTAG
ATAAAAGTACGGGGACGGTCTATTTTGAAAATGGTGGCGTTTGCTATGTTTCAAAATTGAAACTAAAGAAATTGATTGAG
AGAATTGGACGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-123)

• LytTr DNA-binding domain (LytTR) (151-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	51.464	97.951	0.504
comE/comE1	Streptococcus equinus JB1	47.28	97.951	0.463
comE/comE2	Streptococcus equinus JB1	42.857	97.541	0.418
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.095	99.59	0.389
comE/comE2	Streptococcus gordonii strain NCTC7865	39.095	99.59	0.389
comE	Streptococcus infantis strain Atu-4	37.759	98.77	0.373
comE	Streptococcus pneumoniae D39	37.344	98.77	0.369
comE	Streptococcus pneumoniae R6	37.344	98.77	0.369
comE	Streptococcus pneumoniae Rx1	37.344	98.77	0.369
comE	Streptococcus mitis SK321	37.344	98.77	0.369
comE	Streptococcus mitis NCTC 12261	37.344	98.77	0.369
comE	Streptococcus pneumoniae TIGR4	37.344	98.77	0.369