Detailed information NTG0178209

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: NX99_RS04730
• Genome accession: NZ_CP015282
• Coordinates: 1099985..1100719 (-)
• Length: 244 a.a.
• NCBI ID: WP_048676267.1
• Uniprot ID: A0AAW6DBQ9
• Organism: Streptococcus salivarius strain ATCC 27945
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1094985..1105719

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NX99_RS04720 (NX99_04635)	-	1098014..1098571 (-)	558	WP_084914946.1	transcriptional regulator	-
NX99_RS04725 (NX99_04640)	-	1098669..1099988 (-)	1320	WP_084914948.1	sensor histidine kinase	-
NX99_RS04730 (NX99_04645)	comE/blpR	1099985..1100719 (-)	735	WP_048676267.1	response regulator transcription factor	Regulator
NX99_RS04735 (NX99_04650)	-	1100930..1102714 (-)	1785	WP_084914950.1	SH3 domain-containing protein	-
NX99_RS04740 (NX99_04655)	-	1102991..1103290 (-)	300	WP_084914952.1	hypothetical protein	-
NX99_RS04745 (NX99_04660)	-	1103355..1104047 (-)	693	WP_084914953.1	DUF6287 domain-containing protein	-
NX99_RS04750 (NX99_04665)	-	1104186..1105109 (-)	924	WP_084914955.1	helix-turn-helix domain-containing protein	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28554.90 Da
• Isoelectric Point: 6.3900

>NTDB_id=178209 NX99_RS04730 WP_048676267.1 1099985..1100719(-) (comE/blpR) [Streptococcus salivarius strain ATCC 27945]
MLNIYVLEDHFIQQNRIEEVIHTILKKNNIKVGDFEVFDKPNQLLESITERGSHQLFFLDIQIKDDTKKGLEVAKQIRKN
DPYANIVFFTTHSEYLPLTFQYQLAALDFIDKSLEGEDFQKRVESIILLTCKKIQSQNPEDAFRIENAKTVIQVPFHDIL
YFETSDIVHKVILYTKEEQIEFYGSLSQIEKSDPRLFKCHKSFLINPENIIKLDKSTGTVYFENGGVCYVSKLKLKKLLE
RISL

Nucleotide

• Length: 735 bp

>NTDB_id=178209 NX99_RS04730 WP_048676267.1 1099985..1100719(-) (comE/blpR) [Streptococcus salivarius strain ATCC 27945]
ATGCTTAACATCTATGTTTTAGAAGATCATTTTATCCAACAAAATCGTATTGAAGAGGTTATTCATACGATTCTTAAGAA
AAATAATATTAAAGTGGGGGACTTTGAGGTTTTTGACAAACCCAATCAACTGTTAGAGTCTATTACCGAGCGAGGGTCTC
ATCAGCTCTTTTTCTTGGACATTCAAATTAAAGACGATACTAAAAAAGGTTTGGAAGTGGCTAAGCAGATTCGCAAGAAT
GATCCCTATGCCAATATTGTTTTCTTCACGACCCATTCAGAGTATCTTCCCTTGACTTTTCAATACCAACTGGCAGCTCT
AGACTTTATTGATAAGTCTTTGGAGGGTGAGGACTTTCAAAAGCGTGTGGAAAGTATTATCTTATTAACCTGCAAAAAGA
TACAGAGTCAGAATCCAGAAGACGCTTTTCGGATTGAGAATGCTAAGACCGTTATTCAGGTTCCTTTTCATGATATCTTG
TACTTTGAGACGTCAGATATTGTTCATAAGGTTATCCTTTATACTAAAGAGGAGCAGATTGAGTTTTATGGCAGTCTCTC
ACAAATCGAAAAGAGTGACCCTAGACTGTTTAAATGCCACAAATCTTTCCTTATCAATCCAGAAAATATCATCAAATTAG
ATAAAAGTACGGGGACAGTCTATTTTGAAAATGGTGGCGTTTGCTATGTTTCAAAGTTGAAACTAAAGAAATTGCTTGAG
AGAATCAGCCTATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-242)

• Response regulator receiver domain (Response_reg) (6-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	51.23	100	0.512
comE/comE1	Streptococcus equinus JB1	48.117	97.951	0.471
comE/comE2	Streptococcus equinus JB1	42.562	99.18	0.422
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.683	99.59	0.385
comE/comE2	Streptococcus gordonii strain NCTC7865	38.683	99.59	0.385
comE	Streptococcus infantis strain Atu-4	37.759	98.77	0.373
comE	Streptococcus pneumoniae D39	37.344	98.77	0.369
comE	Streptococcus pneumoniae R6	37.344	98.77	0.369
comE	Streptococcus pneumoniae Rx1	37.344	98.77	0.369
comE	Streptococcus mitis SK321	37.344	98.77	0.369
comE	Streptococcus mitis NCTC 12261	37.344	98.77	0.369
comE	Streptococcus pneumoniae TIGR4	37.344	98.77	0.369