Detailed information NTG0168726

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AWB63_RS02655
• Genome accession: NZ_CP014144
• Coordinates: 538769..539503 (-)
• Length: 244 a.a.
• NCBI ID: WP_038675437.1
• Uniprot ID: A0AB35IPB9
• Organism: Streptococcus salivarius strain JF
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 533769..544503

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AWB63_RS02645 (AWB63_02645)	-	536705..537355 (-)	651	WP_038675440.1	DUF6287 domain-containing protein	-
AWB63_RS02650 (AWB63_02650)	-	537453..538772 (-)	1320	WP_038675438.1	sensor histidine kinase	-
AWB63_RS02655 (AWB63_02655)	comE/blpR	538769..539503 (-)	735	WP_038675437.1	response regulator transcription factor	Regulator
AWB63_RS02660 (AWB63_02660)	-	539751..540416 (-)	666	WP_038675435.1	DUF6287 domain-containing protein	-
AWB63_RS02665 (AWB63_02665)	-	540551..541303 (-)	753	WP_038675433.1	response regulator transcription factor	-
AWB63_RS02670 (AWB63_02670)	-	541624..542873 (+)	1250	Protein_494	ISL3 family transposase	-
AWB63_RS10880	-	542943..544031 (-)	1089	Protein_495	SH3 domain-containing protein	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28540.87 Da
• Isoelectric Point: 6.3900

>NTDB_id=168726 AWB63_RS02655 WP_038675437.1 538769..539503(-) (comE/blpR) [Streptococcus salivarius strain JF]
MLNIYVLEDHFIQQNRIEEVIHTILKKNNIKVGDFEVFDKPNQLLESITERGSHQLFFLDIQIKDDTKKGLEVAKQIRKN
DPYANIVFFTTHSEYLPLTFQYQLAALDFIDKSLEGEDFQKRVESIILLTCKKIQSQNPEDAFRIENAKTVIQVPFHDIL
YFETSDIVHKVILYTKEEQIEFYGSLSQIEKSDPRLFKCHKSFLINPENVIKLDKSTGTVYFENGGVCYVSKLKLKKLLE
RISL

Nucleotide

• Length: 735 bp

>NTDB_id=168726 AWB63_RS02655 WP_038675437.1 538769..539503(-) (comE/blpR) [Streptococcus salivarius strain JF]
ATGCTTAACATCTATGTTTTAGAGGATCATTTTATCCAACAAAATCGTATTGAAGAGGTTATTCATACGATTCTTAAGAA
AAATAATATTAAAGTGGGTGACTTTGAGGTTTTTGACAAACCCAATCAACTGTTAGAGTCTATTACCGAGCGAGGGTCTC
ATCAGCTCTTTTTCTTGGACATTCAAATTAAAGACGATACTAAAAAAGGTTTGGAAGTGGCTAAGCAGATTCGCAAGAAT
GATCCCTATGCCAATATTGTTTTCTTCACGACTCATTCAGAGTATCTTCCCTTAACTTTTCAATACCAACTGGCAGCTCT
AGACTTTATTGATAAGTCTTTGGAGGGTGAGGACTTTCAAAAGCGAGTGGAAAGTATTATCTTATTAACCTGCAAAAAGA
TACAGAGTCAGAATCCAGAAGACGCTTTTCGGATTGAGAATGCTAAGACCGTTATTCAGGTTCCTTTTCATGATATCTTG
TACTTTGAGACGTCAGATATTGTTCATAAGGTTATCCTTTATACTAAAGAGGAGCAGATTGAGTTTTATGGCAGTCTCTC
ACAAATCGAAAAGAGTGACCCTAGACTGTTTAAATGCCACAAATCTTTCCTTATCAACCCAGAAAATGTCATCAAATTAG
ATAAAAGTACGGGGACAGTCTATTTTGAAAATGGTGGCGTTTGCTATGTTTCAAAGTTGAAACTAAAGAAATTGCTTGAG
AGAATCAGCCTATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-123)

• LytTr DNA-binding domain (LytTR) (151-242)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	50.82	100	0.508
comE/comE1	Streptococcus equinus JB1	48.536	97.951	0.475
comE/comE2	Streptococcus equinus JB1	42.149	99.18	0.418
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.272	99.59	0.381
comE/comE2	Streptococcus gordonii strain NCTC7865	38.272	99.59	0.381
comE	Streptococcus infantis strain Atu-4	37.344	98.77	0.369
comE	Streptococcus pneumoniae D39	36.929	98.77	0.365
comE	Streptococcus pneumoniae R6	36.929	98.77	0.365
comE	Streptococcus pneumoniae Rx1	36.929	98.77	0.365
comE	Streptococcus mitis SK321	36.929	98.77	0.365
comE	Streptococcus mitis NCTC 12261	36.929	98.77	0.365
comE	Streptococcus pneumoniae TIGR4	36.929	98.77	0.365