Detailed information NTG0163408

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ATM98_RS05735
• Genome accession: NZ_CP013651
• Coordinates: 1173078..1173815 (+)
• Length: 245 a.a.
• NCBI ID: WP_040803104.1
• Uniprot ID: -
• Organism: Streptococcus sp. A12
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1168078..1178815

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ATM98_RS09740	-	1169135..1169545 (-)	411	WP_237367519.1	hypothetical protein	-
ATM98_RS05725 (ATM98_05730)	-	1169590..1170630 (-)	1041	WP_237367520.1	hypothetical protein	-
ATM98_RS05730 (ATM98_05735)	pepF	1170805..1172601 (+)	1797	WP_061564391.1	oligoendopeptidase F	-
ATM98_RS05735 (ATM98_05740)	comE/blpR	1173078..1173815 (+)	738	WP_040803104.1	response regulator transcription factor	Regulator
ATM98_RS05740 (ATM98_05745)	-	1173812..1175149 (+)	1338	WP_061564392.1	GHKL domain-containing protein	-
ATM98_RS05745 (ATM98_05750)	-	1175349..1176098 (+)	750	WP_061564393.1	amino acid transporter	-
ATM98_RS05750 (ATM98_05755)	-	1176151..1177026 (+)	876	WP_061564394.1	ABC transporter ATP-binding protein	-
ATM98_RS05755 (ATM98_05760)	-	1177030..1177803 (+)	774	WP_061564395.1	hypothetical protein	-
ATM98_RS05760 (ATM98_05765)	trxA	1177930..1178244 (-)	315	WP_061564396.1	thioredoxin	-
ATM98_RS05765 (ATM98_05770)	-	1178257..1178481 (-)	225	WP_061564397.1	DUF4649 family protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28429.44 Da
• Isoelectric Point: 6.6629

>NTDB_id=163408 ATM98_RS05735 WP_040803104.1 1173078..1173815(+) (comE/blpR) [Streptococcus sp. A12]
MLNIFVLEDDFLQQTRIETAIKKCMTDHHLKYKYLEVFGKPTQLLEAIKETGNHQFFFLDIEIKGEEKKGMEIAREIREK
DPSASIVFVTTHSEFMPVTYRYRVSALDFIDKGLNDQDYQEAISSVLIHAAENVNKTIGEDSFSFKSEHSQIQVPFSDIL
YFETSSTVHKVVLTTKKGHMEFYGKVSDIAKTDKRLYQSHRAYVVNPENVVRIDKANHIVYFENDESCFVSRLKLKGLVE
KVDKK

Nucleotide

• Length: 738 bp

>NTDB_id=163408 ATM98_RS05735 WP_040803104.1 1173078..1173815(+) (comE/blpR) [Streptococcus sp. A12]
ATGCTAAATATCTTTGTATTAGAAGATGATTTTCTACAACAAACACGTATTGAAACAGCAATCAAGAAATGTATGACAGA
TCATCATCTAAAGTATAAATACTTAGAGGTATTTGGGAAGCCAACACAATTGTTAGAGGCCATCAAAGAGACAGGAAATC
ACCAATTCTTTTTTTTAGATATTGAAATTAAAGGGGAAGAAAAAAAAGGAATGGAAATTGCGCGTGAAATTCGTGAAAAA
GATCCTAGCGCTTCAATCGTATTCGTAACGACTCACTCAGAATTCATGCCCGTTACCTATCGTTATCGCGTCTCCGCTTT
GGATTTTATTGATAAAGGATTAAATGATCAGGATTATCAGGAAGCGATCTCATCTGTTTTGATACATGCTGCTGAGAACG
TCAATAAGACAATAGGGGAGGATTCCTTCAGCTTTAAATCAGAGCATTCCCAGATTCAAGTCCCTTTCTCAGATATTCTA
TATTTTGAGACATCTTCGACCGTTCATAAGGTCGTTTTAACAACTAAAAAAGGACACATGGAATTTTATGGTAAAGTCTC
AGATATTGCTAAAACCGACAAGCGACTTTACCAAAGTCATCGAGCTTACGTTGTAAATCCAGAGAATGTCGTGCGTATTG
ATAAAGCAAATCATATTGTTTATTTTGAAAACGATGAATCATGTTTTGTATCACGTTTAAAACTGAAAGGGCTAGTTGAA
AAGGTAGATAAAAAATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	57.741	97.551	0.563
comE/comE1	Streptococcus equinus JB1	49.174	98.776	0.486
comE/comE2	Streptococcus equinus JB1	40.741	99.184	0.404
comE	Streptococcus infantis strain Atu-4	36.145	100	0.367
comE/comE2	Streptococcus gordonii strain NCTC7865	36.626	99.184	0.363
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	36.626	99.184	0.363
comE	Streptococcus mitis SK321	35.743	100	0.363
comE	Streptococcus pneumoniae Rx1	35.743	100	0.363
comE	Streptococcus pneumoniae D39	35.743	100	0.363
comE	Streptococcus pneumoniae R6	35.743	100	0.363
comE	Streptococcus pneumoniae TIGR4	35.743	100	0.363
comE	Streptococcus mitis NCTC 12261	35.743	100	0.363