Detailed information NTG0160696

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: HSISS4_RS02135
• Genome accession: NZ_CP013216
• Coordinates: 424458..425192 (+)
• Length: 244 a.a.
• NCBI ID: WP_021144603.1
• Uniprot ID: A0AAW7PF39
• Organism: Streptococcus salivarius strain HSISS4
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 419458..430192

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HSISS4_RS02120 (HSISS4_00375)	-	419896..422451 (+)	2556	WP_021144604.1	SH3 domain-containing protein	-
HSISS4_RS10180 (HSISS4_00376)	-	422562..423527 (-)	966	WP_002890057.1	IS3 family transposase	-
HSISS4_RS02130 (HSISS4_00377)	-	423524..424201 (-)	678	WP_059749084.1	helix-turn-helix domain-containing protein	-
HSISS4_RS02135 (HSISS4_00378)	comE/blpR	424458..425192 (+)	735	WP_021144603.1	response regulator transcription factor	Regulator
HSISS4_RS02140 (HSISS4_00379)	-	425189..426508 (+)	1320	WP_021144602.1	sensor histidine kinase	-
HSISS4_RS02145 (HSISS4_00380)	-	426606..427256 (+)	651	WP_021144601.1	DUF6287 domain-containing protein	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28556.83 Da
• Isoelectric Point: 6.3900

>NTDB_id=160696 HSISS4_RS02135 WP_021144603.1 424458..425192(+) (comE/blpR) [Streptococcus salivarius strain HSISS4]
MLNIYVLEDHFIQQNRIEEVIHTILKKNNIKVGDFEVFDKPNQLLESITERGSHQLFFLDIQIKDDTKKGLEVAKQIRRN
DPYANIVFFTTHSEYLPLTFQYQLAALDFIDKSLEGEDFQKRVESVILLTCKKTQSQNPEDAFRIENAKTVIQVPFHDIL
YFETSDIVHKVILYTKEEQIEFYGSLSQIEKSDPRLFKCHKSFLINPENIIKLDKSTGTVYFENGGVCYVSKLKLKKLLE
RISL

Nucleotide

• Length: 735 bp

>NTDB_id=160696 HSISS4_RS02135 WP_021144603.1 424458..425192(+) (comE/blpR) [Streptococcus salivarius strain HSISS4]
ATGCTTAACATCTATGTTTTAGAGGATCATTTTATCCAACAAAATCGTATTGAAGAGGTTATTCATACGATTCTTAAGAA
AAATAATATTAAAGTGGGGGACTTTGAGGTTTTTGACAAACCCAATCAACTGTTAGAGTCTATTACCGAGCGAGGGTCTC
ATCAGCTCTTTTTCTTGGACATTCAAATTAAAGACGATACTAAAAAAGGTTTGGAAGTGGCTAAGCAGATTCGCAGGAAT
GATCCCTATGCCAATATTGTTTTCTTCACGACCCATTCAGAGTATCTTCCCTTGACTTTTCAATACCAACTGGCAGCTCT
AGACTTTATTGATAAGTCTTTGGAGGGTGAGGACTTTCAAAAGCGTGTGGAAAGTGTTATCTTATTAACCTGCAAAAAGA
CACAGAGTCAGAATCCAGAAGATGCTTTTCGGATTGAGAATGCTAAGACCGTTATTCAGGTTCCCTTTCATGATATCTTA
TACTTTGAGACATCAGACATTGTTCACAAGGTTATCCTTTATACCAAAGAGGAGCAGATTGAGTTTTATGGCAGTCTCTC
ACAAATCGAAAAGAGTGACCCTAGACTGTTTAAATGCCACAAATCTTTCCTTATCAACCCAGAAAATATCATCAAATTAG
ATAAAAGTACGGGGACAGTCTATTTTGAAAATGGTGGCGTTTGCTATGTTTCAAAGTTGAAACTAAAGAAATTGCTTGAG
AGAATCAGCCTATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-242)

• Response regulator receiver domain (Response_reg) (6-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	51.23	100	0.512
comE/comE1	Streptococcus equinus JB1	48.117	97.951	0.471
comE/comE2	Streptococcus equinus JB1	42.562	99.18	0.422
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.272	99.59	0.381
comE/comE2	Streptococcus gordonii strain NCTC7865	38.272	99.59	0.381
comE	Streptococcus infantis strain Atu-4	38.174	98.77	0.377
comE	Streptococcus pneumoniae D39	37.344	98.77	0.369
comE	Streptococcus pneumoniae R6	37.344	98.77	0.369
comE	Streptococcus pneumoniae Rx1	37.344	98.77	0.369
comE	Streptococcus mitis SK321	37.344	98.77	0.369
comE	Streptococcus mitis NCTC 12261	37.344	98.77	0.369
comE	Streptococcus pneumoniae TIGR4	37.344	98.77	0.369