Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   SanJ4206_RS09225 Genome accession   NZ_CP012719
Coordinates   1888829..1890097 (-) Length   422 a.a.
NCBI ID   WP_022525214.1    Uniprot ID   A0AAI9J627
Organism   Streptococcus anginosus strain J4206     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1856276..1895968 1888829..1890097 within 0


Gene organization within MGE regions


Location: 1856276..1895968
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SanJ4206_RS09065 (SanJ4206_1766c) - 1856276..1858150 (-) 1875 WP_157622117.1 phosphotransferase -
  SanJ4206_RS09070 (SanJ4206_1767) - 1858330..1859562 (+) 1233 WP_003027733.1 nucleotide sugar dehydrogenase -
  SanJ4206_RS09075 (SanJ4206_1768c) - 1860063..1860470 (-) 408 WP_003027735.1 serine O-acetyltransferase -
  SanJ4206_RS09080 (SanJ4206_1769c) - 1860500..1861321 (-) 822 WP_003027736.1 LicD family protein -
  SanJ4206_RS09085 (SanJ4206_1770c) - 1861397..1862353 (-) 957 WP_022525202.1 capsular polysaccharide synthesis protein -
  SanJ4206_RS09090 (SanJ4206_1771c) - 1862464..1863474 (-) 1011 WP_003027738.1 acyltransferase family protein -
  SanJ4206_RS09095 (SanJ4206_1772c) - 1863492..1864940 (-) 1449 WP_003027739.1 flippase -
  SanJ4206_RS09100 (SanJ4206_1773c) - 1864940..1866106 (-) 1167 WP_022525206.1 glycosyltransferase family 4 protein -
  SanJ4206_RS09105 (SanJ4206_1774c) - 1866123..1867409 (-) 1287 WP_003027741.1 O-antigen polymerase -
  SanJ4206_RS09110 (SanJ4206_1775c) - 1867433..1868347 (-) 915 WP_003027742.1 glycosyltransferase -
  SanJ4206_RS09115 (SanJ4206_1776c) cps2T 1868344..1869525 (-) 1182 WP_022525207.1 beta 1-4 rhamnosyltransferase Cps2T -
  SanJ4206_RS09120 (SanJ4206_1777c) - 1869563..1870936 (-) 1374 WP_003027744.1 sugar transferase -
  SanJ4206_RS09125 (SanJ4206_1778c) - 1870959..1871654 (-) 696 WP_003026604.1 tyrosine-protein kinase -
  SanJ4206_RS09130 (SanJ4206_1779c) - 1871667..1872362 (-) 696 WP_157622119.1 CspC family polysaccharide chain length determinant protein -
  SanJ4206_RS09135 (SanJ4206_1780c) cps4B 1872371..1873102 (-) 732 WP_022525209.1 capsular polysaccharide biosynthesis protein Cps4B -
  SanJ4206_RS09140 (SanJ4206_1781c) - 1873105..1874556 (-) 1452 WP_022525210.1 LCP family protein -
  SanJ4206_RS09145 (SanJ4206_1782c) nrdG 1874904..1875509 (-) 606 WP_003027750.1 anaerobic ribonucleoside-triphosphate reductase activating protein -
  SanJ4206_RS09150 (SanJ4206_1783c) - 1875514..1876017 (-) 504 WP_003027752.1 GNAT family N-acetyltransferase -
  SanJ4206_RS09155 (SanJ4206_1784c) - 1876027..1876524 (-) 498 WP_003027754.1 GNAT family N-acetyltransferase -
  SanJ4206_RS09160 (SanJ4206_1785c) - 1876584..1876724 (-) 141 WP_003027756.1 hypothetical protein -
  SanJ4206_RS09165 (SanJ4206_1786c) nrdD 1876733..1878943 (-) 2211 WP_022525211.1 anaerobic ribonucleoside-triphosphate reductase -
  SanJ4206_RS09170 (SanJ4206_1787c) - 1879051..1880592 (-) 1542 WP_003027759.1 hypothetical protein -
  SanJ4206_RS10055 (SanJ4206_1788c) - 1880647..1880781 (-) 135 WP_003027761.1 hypothetical protein -
  SanJ4206_RS09175 (SanJ4206_1789c) cls 1880845..1882377 (-) 1533 WP_157622121.1 cardiolipin synthase -
  SanJ4206_RS09180 (SanJ4206_1790c) - 1882771..1883208 (-) 438 WP_003027763.1 SP_0198 family lipoprotein -
  SanJ4206_RS09185 (SanJ4206_1791c) - 1883257..1884498 (-) 1242 WP_003027764.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase -
  SanJ4206_RS09190 (SanJ4206_1792c) - 1884699..1885010 (-) 312 WP_003027765.1 DUF1292 domain-containing protein -
  SanJ4206_RS09195 (SanJ4206_1793c) ruvX 1885028..1885447 (-) 420 WP_003027766.1 Holliday junction resolvase RuvX -
  SanJ4206_RS09200 (SanJ4206_1794c) - 1885447..1885713 (-) 267 WP_009569646.1 IreB family regulatory phosphoprotein -
  SanJ4206_RS09205 (SanJ4206_1795c) - 1885836..1886393 (-) 558 WP_022525213.1 SP0191 family lipoprotein -
  SanJ4206_RS09210 (SanJ4206_1796c) - 1886498..1887067 (-) 570 WP_003027769.1 SP0191 family lipoprotein -
  SanJ4206_RS09215 (SanJ4206_1797c) spx 1887151..1887549 (-) 399 WP_003027770.1 transcriptional regulator Spx -
  SanJ4206_RS09220 (SanJ4206_1798c) recA 1887636..1888781 (-) 1146 WP_003027772.1 recombinase RecA Machinery gene
  SanJ4206_RS09225 (SanJ4206_1799c) cinA 1888829..1890097 (-) 1269 WP_022525214.1 competence/damage-inducible protein A Machinery gene
  SanJ4206_RS09235 (SanJ4206_1800) - 1890367..1890777 (+) 411 WP_003027775.1 helix-turn-helix domain-containing protein -
  SanJ4206_RS09240 - 1890828..1891486 (-) 659 Protein_1779 type II CAAX prenyl endopeptidase Rce1 family protein -
  SanJ4206_RS09245 (SanJ4206_1801c) - 1891491..1892045 (-) 555 WP_003027778.1 DNA-3-methyladenine glycosylase I -
  SanJ4206_RS09250 (SanJ4206_1802c) ruvA 1892055..1892645 (-) 591 WP_003027779.1 Holliday junction branch migration protein RuvA -
  SanJ4206_RS09255 (SanJ4206_1803c) mutL 1892779..1894725 (-) 1947 WP_037593386.1 DNA mismatch repair endonuclease MutL -
  SanJ4206_RS09260 (SanJ4206_1804c) - 1894820..1895968 (-) 1149 WP_003027782.1 tyrosine-type recombinase/integrase -

Sequence

Protein


Download         Length: 422 a.a.        Molecular weight: 45742.26 Da        Isoelectric Point: 6.5228

>NTDB_id=156803 SanJ4206_RS09225 WP_022525214.1 1888829..1890097(-) (cinA) [Streptococcus anginosus strain J4206]
MKAEIIAVGTEILTGQIVNTNAQFLSEKLASLGVDVYFQTAVGDNEARLLSILEIARNRSNLIILTGGLGPTEDDLTKQT
LSKFLNRRLVFDRMATEKLDRFFASRPDYVRTPNNERQAQIVEGSTSLQNETGLAVGGVIEVSGVTYVVLPGPPSELKPM
VNNELVPLLATGQKLYSRVLRFFGIGESQLVTLLGDLIDTQTDPTIAPYAKTGEVTLRLSTKATSQKEADVKFTRLEKKI
LAVQTFEKQHLADLFYAYGDDNSLGQTAFELLRRAGKTVTAAESLTAGLFQATLANFAGASNVFSGGFVTYSMEEKSRML
GIPLADLEKHGVVSAFTAEKMAEQARKLTASDYAVSLTGVAGPDSLEGHPAGTVYIGLATTEDVQSIKVNIAGRSRTDVR
KIAVLHAFNLLRKTLSKNENML

Nucleotide


Download         Length: 1269 bp        

>NTDB_id=156803 SanJ4206_RS09225 WP_022525214.1 1888829..1890097(-) (cinA) [Streptococcus anginosus strain J4206]
ATGAAAGCAGAAATTATTGCTGTGGGTACTGAAATTCTGACAGGTCAAATTGTCAATACAAACGCCCAATTTTTATCTGA
AAAATTAGCGAGTCTGGGAGTAGATGTGTATTTCCAAACAGCGGTCGGAGATAATGAAGCTCGTCTGTTATCCATTTTAG
AAATCGCTCGAAATCGTAGTAATTTGATCATCTTAACTGGAGGATTAGGTCCAACAGAAGATGACTTGACTAAGCAGACT
TTGTCAAAATTCTTAAATCGTAGGTTGGTATTTGACCGAATGGCTACGGAGAAATTGGATCGCTTCTTCGCAAGTCGACC
GGACTATGTGCGAACACCCAATAATGAGCGACAAGCTCAGATAGTGGAAGGCTCGACCTCTCTCCAAAACGAAACCGGAC
TTGCAGTGGGGGGCGTGATTGAAGTCAGTGGGGTGACTTATGTCGTTCTGCCTGGACCGCCTAGTGAATTAAAACCTATG
GTAAATAATGAGCTGGTTCCGCTCTTAGCAACTGGTCAAAAATTGTATTCAAGAGTTTTGCGTTTCTTTGGTATTGGTGA
AAGTCAATTAGTAACCCTTTTAGGGGATTTAATTGATACTCAAACGGATCCGACCATTGCTCCTTATGCTAAGACGGGAG
AAGTAACTTTGCGATTGTCCACCAAGGCTACTAGTCAAAAGGAAGCGGATGTTAAGTTTACTCGTTTAGAAAAGAAAATT
TTAGCAGTACAAACTTTTGAGAAACAACATTTAGCTGATCTTTTCTACGCTTATGGAGATGATAATTCTCTGGGACAAAC
AGCTTTTGAACTGCTGAGAAGAGCAGGAAAGACCGTCACAGCAGCTGAAAGTTTGACTGCAGGACTTTTTCAAGCAACTT
TAGCAAACTTTGCTGGTGCCTCCAATGTTTTTAGTGGTGGCTTTGTTACCTACAGTATGGAGGAAAAGAGCCGAATGCTG
GGCATTCCCTTGGCAGACTTGGAAAAGCATGGGGTGGTTTCAGCTTTTACAGCAGAGAAAATGGCTGAGCAGGCAAGAAA
ATTGACCGCTAGTGACTATGCGGTGAGCTTGACAGGTGTGGCAGGTCCAGATAGCTTAGAAGGACATCCAGCAGGGACAG
TTTATATCGGCTTAGCAACCACAGAGGATGTTCAGTCTATTAAGGTTAATATTGCGGGTCGCAGTCGGACAGATGTACGT
AAAATAGCCGTTCTGCATGCTTTCAATCTGCTGCGAAAAACTTTATCAAAAAACGAAAATATGCTATAA

Domains

Predicted by InterproScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(177-240)

Competence-damaged protein (CinA)

(263-415)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mitis SK321

76.145

98.341

0.749
  cinA Streptococcus mitis NCTC 12261

75.181

98.341

0.739
  cinA Streptococcus pneumoniae Rx1

74.94

98.341

0.737
  cinA Streptococcus pneumoniae R6

74.94

98.341

0.737
  cinA Streptococcus pneumoniae TIGR4

74.94

98.341

0.737
  cinA Streptococcus pneumoniae D39

74.699

98.341

0.735
  cinA Streptococcus mutans UA159

72.577

100

0.727
  cinA Streptococcus suis isolate S10

56.01

98.578

0.552
  cinA Bacillus subtilis subsp. subtilis str. 168

45.714

99.526

0.455

Multiple sequence alignment