Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   RN86_RS01175 Genome accession   NZ_CP012648
Coordinates   246723..247457 (-) Length   244 a.a.
NCBI ID   WP_053794151.1    Uniprot ID   -
Organism   Streptococcus gordonii strain KCOM 1506 (= ChDC B679)     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 241051..254492 246723..247457 within 0


Gene organization within MGE regions


Location: 241051..254492
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RN86_RS01140 (RN86_01135) - 241051..241599 (-) 549 WP_048775562.1 DUF6609 family protein -
  RN86_RS01145 (RN86_01140) - 241888..242340 (+) 453 WP_053794148.1 DUF3290 family protein -
  RN86_RS01150 (RN86_01145) - 242337..242969 (+) 633 WP_111705855.1 DUF421 domain-containing protein -
  RN86_RS01155 (RN86_01150) - 243151..243354 (+) 204 WP_008808393.1 CsbD family protein -
  RN86_RS01160 (RN86_01155) - 243706..244425 (-) 720 WP_008808392.1 hypothetical protein -
  RN86_RS01165 (RN86_01160) - 244418..245098 (-) 681 WP_008808391.1 ABC transporter ATP-binding protein -
  RN86_RS01170 (RN86_01165) - 245382..246710 (-) 1329 WP_053794150.1 GHKL domain-containing protein -
  RN86_RS01175 (RN86_01170) comE/blpR 246723..247457 (-) 735 WP_053794151.1 LytTR family DNA-binding domain-containing protein Regulator
  RN86_RS11170 - 248131..248256 (+) 126 Protein_222 integrase -
  RN86_RS11425 - 248857..249024 (-) 168 WP_020992799.1 hypothetical protein -
  RN86_RS01185 (RN86_01180) - 249038..249691 (-) 654 WP_000677415.1 ABC-2 transporter permease -
  RN86_RS01190 (RN86_01185) - 249672..250529 (-) 858 WP_008808388.1 ABC transporter ATP-binding protein -
  RN86_RS01195 (RN86_01190) - 250543..251055 (-) 513 WP_020992800.1 hypothetical protein -
  RN86_RS01200 (RN86_01195) - 251067..251534 (-) 468 WP_008808387.1 stage II sporulation protein M -
  RN86_RS01205 (RN86_01200) - 251622..251900 (-) 279 WP_008808386.1 class IIc cyclic bacteriocin -
  RN86_RS01210 (RN86_01205) - 252345..253211 (-) 867 WP_105165082.1 Rgg/GadR/MutR family transcriptional regulator -
  RN86_RS01215 - 253322..253894 (-) 573 WP_008808384.1 helix-turn-helix transcriptional regulator -
  RN86_RS01220 (RN86_01215) - 254049..254492 (+) 444 WP_046165025.1 hypothetical protein -

Sequence

Protein


Download         Length: 244 a.a.        Molecular weight: 28628.03 Da        Isoelectric Point: 6.3965

>NTDB_id=156054 RN86_RS01175 WP_053794151.1 246723..247457(-) (comE/blpR) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
MLNIYVLEDEILQQSRMETIIYKVLKDENLKINKFEIFGKPSQLLAEITERGDHQLFFLDIEIKDEEKKGLELAYQIRKL
DPNATIVFVTTHSEFMPLTFRYKVSALDFIDKALGDLHFYERVKSAIEYTLEKNGSTVAHDSFKFETSLSRVQVPFNKIL
YFETSPTVHKVIMHTIDERLEFYAGISEIEKTDNRLYRCHKSFVVNPENISKIDKENKLILFENGEGCLVSKTKLKKLKE
RLDF

Nucleotide


Download         Length: 735 bp        

>NTDB_id=156054 RN86_RS01175 WP_053794151.1 246723..247457(-) (comE/blpR) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
ATGCTAAACATTTATGTTTTGGAAGACGAAATACTACAACAGTCTCGCATGGAGACTATTATTTATAAGGTGCTAAAAGA
TGAAAATTTAAAAATTAATAAGTTTGAGATTTTTGGAAAGCCATCTCAATTATTAGCAGAGATAACTGAGAGAGGGGATC
ATCAGTTATTTTTTTTAGATATTGAGATCAAGGATGAAGAGAAAAAAGGATTGGAGCTTGCTTATCAAATTAGAAAGCTC
GATCCCAATGCAACTATTGTCTTTGTGACTACCCATTCTGAGTTTATGCCATTAACATTTAGATATAAAGTTAGTGCTTT
GGATTTTATTGATAAGGCACTTGGTGATCTTCATTTTTATGAAAGAGTAAAATCAGCGATTGAATATACATTGGAAAAAA
ATGGAAGTACTGTTGCTCATGATTCTTTTAAATTCGAAACATCACTATCTCGTGTCCAAGTTCCATTTAATAAAATTCTT
TATTTTGAAACATCGCCTACTGTGCATAAGGTTATTATGCATACGATAGATGAAAGATTAGAATTTTATGCTGGAATTTC
TGAGATTGAAAAAACGGATAATAGGTTATACAGATGTCACAAGTCGTTTGTCGTAAATCCTGAAAACATTAGTAAGATTG
ATAAGGAAAATAAGCTAATTCTATTTGAAAATGGAGAAGGTTGCTTAGTTTCTAAGACTAAATTAAAGAAACTCAAGGAA
AGGTTAGATTTTTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-242)

Response regulator receiver domain (Response_reg)

(5-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

55.372

99.18

0.549
  comE/comE1 Streptococcus equinus JB1

45.378

97.541

0.443
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

41.296

100

0.418
  comE/comE2 Streptococcus gordonii strain NCTC7865

41.296

100

0.418
  comE Streptococcus pneumoniae D39

38.306

100

0.389
  comE Streptococcus pneumoniae Rx1

38.306

100

0.389
  comE Streptococcus mitis SK321

38.306

100

0.389
  comE Streptococcus mitis NCTC 12261

38.306

100

0.389
  comE Streptococcus pneumoniae R6

38.306

100

0.389
  comE Streptococcus pneumoniae TIGR4

38.306

100

0.389
  comE/comE2 Streptococcus equinus JB1

38.683

99.59

0.385
  comE Streptococcus infantis strain Atu-4

36.694

100

0.373

Multiple sequence alignment