Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   VU19_RS00635 Genome accession   NZ_CP011068
Coordinates   101445..102383 (+) Length   312 a.a.
NCBI ID   WP_011284420.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain STAB10015     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 96445..107383
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VU19_RS00625 (VU19_00625) rpoC 97194..100835 (+) 3642 WP_011284419.1 DNA-directed RNA polymerase subunit beta' -
  VU19_RS00630 (VU19_00630) - 100987..101352 (+) 366 WP_002986560.1 DUF1033 family protein -
  VU19_RS00635 (VU19_00635) comYA 101445..102383 (+) 939 WP_011284420.1 competence type IV pilus ATPase ComGA Machinery gene
  VU19_RS00640 (VU19_00640) comYB 102319..103353 (+) 1035 WP_227868694.1 competence type IV pilus assembly protein ComGB Machinery gene
  VU19_RS00645 (VU19_00645) comYC 103355..103681 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  VU19_RS00650 (VU19_00650) comGD 103656..104084 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  VU19_RS00655 (VU19_00655) comGE 104041..104325 (+) 285 WP_011284422.1 competence type IV pilus minor pilin ComGE -
  VU19_RS00660 (VU19_00660) comYF 104318..104752 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  VU19_RS00665 (VU19_00665) comGG 104736..105062 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  VU19_RS00670 (VU19_00670) comYH 105160..106113 (+) 954 WP_010921802.1 class I SAM-dependent methyltransferase Machinery gene
  VU19_RS00675 (VU19_00675) - 106172..107368 (+) 1197 WP_011284424.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35060.33 Da        Isoelectric Point: 8.5799

>NTDB_id=141905 VU19_RS00635 WP_011284420.1 101445..102383(+) (comYA) [Streptococcus pyogenes strain STAB10015]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLISHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISSYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHRPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YVRLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=141905 VU19_RS00635 WP_011284420.1 101445..102383(+) (comYA) [Streptococcus pyogenes strain STAB10015]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTATTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTTAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAGTTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCGACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGTAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.415

99.679

0.612
  comYA Streptococcus mutans UA140

61.415

99.679

0.612
  comYA Streptococcus gordonii str. Challis substr. CH1

60.772

99.679

0.606
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60.323

99.359

0.599
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

59.807

99.679

0.596
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae D39

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae R6

59.164

99.679

0.59
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

59.164

99.679

0.59
  comGA Lactococcus lactis subsp. cremoris KW2

50.482

99.679

0.503
  comGA Latilactobacillus sakei subsp. sakei 23K

39.31

92.949

0.365

Multiple sequence alignment