Detailed information NTG1170403

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACLV7D_RS10255
• Genome accession: NZ_OZ217345
• Coordinates: 2155473..2156225 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866064.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis F22
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2150473..2161225

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7D_RS10235 (SMIF22_20310)	-	2151918..2154560 (-)	2643	WP_164226122.1	YhgE/Pip family protein	-
ACLV7D_RS10240 (SMIF22_20320)	-	2154688..2155230 (+)	543	WP_119941849.1	TetR/AcrR family transcriptional regulator	-
ACLV7D_RS10255 (SMIF22_20350)	comE	2155473..2156225 (-)	753	WP_000866064.1	competence system response regulator transcription factor ComE	Regulator
ACLV7D_RS10260 (SMIF22_20360)	comD/comD2	2156222..2157547 (-)	1326	WP_164226121.1	competence system sensor histidine kinase ComD	Regulator
ACLV7D_RS10265 (SMIF22_20370)	comC/comC2	2157568..2157693 (-)	126	WP_112445417.1	competence-stimulating peptide ComC	Regulator
ACLV7D_RS10275 (SMIF22_20390)	rlmH	2157976..2158455 (-)	480	WP_112445415.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7D_RS10280 (SMIF22_20400)	htrA	2158639..2159820 (+)	1182	WP_112445413.1	S1C family serine protease	Regulator
ACLV7D_RS10285 (SMIF22_20410)	spo0J	2159878..2160636 (+)	759	WP_164226120.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.35 Da
• Isoelectric Point: 6.7051

>NTDB_id=1170403 ACLV7D_RS10255 WP_000866064.1 2155473..2156225(-) (comE) [Streptococcus mitis isolate S. mitis F22]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=1170403 ACLV7D_RS10255 WP_000866064.1 2155473..2156225(-) (comE) [Streptococcus mitis isolate S. mitis F22]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACAGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAACGATGAAGTAAATCAGC
TTTATTTCCTAGATATTGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAACGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTTTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTGGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATCCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTACGTATTATTGGTAAGAATTTTGCCAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATTAGAG
AGATTGATCGAAAAAACCTAGAAATTGTTTTCTATGAAGATCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	98.8	100	0.988
comE	Streptococcus mitis NCTC 12261	98	100	0.98
comE	Streptococcus infantis strain Atu-4	91.6	100	0.916
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408