Detailed information NTG1170406

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACLV7D_RS10280
• Genome accession: NZ_OZ217345
• Coordinates: 2158639..2159820 (+)
• Length: 393 a.a.
• NCBI ID: WP_112445413.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis F22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2153639..2164820

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7D_RS10240 (SMIF22_20320)	-	2154688..2155230 (+)	543	WP_119941849.1	TetR/AcrR family transcriptional regulator	-
ACLV7D_RS10255 (SMIF22_20350)	comE	2155473..2156225 (-)	753	WP_000866064.1	competence system response regulator transcription factor ComE	Regulator
ACLV7D_RS10260 (SMIF22_20360)	comD/comD2	2156222..2157547 (-)	1326	WP_164226121.1	competence system sensor histidine kinase ComD	Regulator
ACLV7D_RS10265 (SMIF22_20370)	comC/comC2	2157568..2157693 (-)	126	WP_112445417.1	competence-stimulating peptide ComC	Regulator
ACLV7D_RS10275 (SMIF22_20390)	rlmH	2157976..2158455 (-)	480	WP_112445415.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7D_RS10280 (SMIF22_20400)	htrA	2158639..2159820 (+)	1182	WP_112445413.1	S1C family serine protease	Regulator
ACLV7D_RS10285 (SMIF22_20410)	spo0J	2159878..2160636 (+)	759	WP_164226120.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41585.41 Da
• Isoelectric Point: 6.1498

>NTDB_id=1170406 ACLV7D_RS10280 WP_112445413.1 2158639..2159820(+) (htrA) [Streptococcus mitis isolate S. mitis F22]
MKHLKTFYKKGFQLLVVIVISFFSGALGSFSIAQLTQKSGVSSSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDETDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNISTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=1170406 ACLV7D_RS10280 WP_112445413.1 2158639..2159820(+) (htrA) [Streptococcus mitis isolate S. mitis F22]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAGCTCAACTAACTCAAAAAAGTGGTGTAAGTAGCTCGAACAACAATAGCACTATCACACAGACTG
CCTATAAAAACGAAAATTCAACAACGCAGGCTGTTAATAAAGTAAAAGATGCCGTTGTATCCGTTATTACTTATTCAGCA
AATAGACAAAATAGCGTATTTGGCAATGATGAGACTGATACAGATTCTCAACAAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCTAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCGGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATTGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTGATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAGGGCCTTGGTTTTGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACACGCCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATATAAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCTGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTGATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATCACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	98.473	100	0.985
htrA	Streptococcus pneumoniae Rx1	97.455	100	0.975
htrA	Streptococcus pneumoniae D39	97.455	100	0.975
htrA	Streptococcus pneumoniae R6	97.455	100	0.975
htrA	Streptococcus pneumoniae TIGR4	97.455	100	0.975
htrA	Streptococcus gordonii str. Challis substr. CH1	66.583	100	0.674
htrA	Streptococcus mutans UA159	54.315	100	0.545