Detailed information NTG1170156

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACLV65_RS10245
• Genome accession: NZ_OZ217342
• Coordinates: 2092231..2092983 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis B22
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2087231..2097983

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV65_RS10225 (SMIB22_20190)	-	2088664..2091318 (-)	2655	WP_411865193.1	YhgE/Pip family protein	-
ACLV65_RS10230 (SMIB22_20200)	-	2091446..2091988 (+)	543	WP_119941849.1	TetR/AcrR family transcriptional regulator	-
ACLV65_RS10245 (SMIB22_20230)	comE	2092231..2092983 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACLV65_RS10250 (SMIB22_20240)	comD/comD2	2092980..2094305 (-)	1326	WP_164226121.1	competence system sensor histidine kinase ComD	Regulator
ACLV65_RS10255 (SMIB22_20250)	comC/comC2	2094326..2094451 (-)	126	WP_112445417.1	competence-stimulating peptide ComC	Regulator
ACLV65_RS10265 (SMIB22_20270)	rlmH	2094734..2095213 (-)	480	WP_000695934.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV65_RS10270 (SMIB22_20280)	htrA	2095397..2096578 (+)	1182	WP_411865194.1	S1C family serine protease	Regulator
ACLV65_RS10275 (SMIB22_20290)	spo0J	2096636..2097394 (+)	759	WP_411865195.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1170156 ACLV65_RS10245 WP_000866065.1 2092231..2092983(-) (comE) [Streptococcus mitis isolate S. mitis B22]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1170156 ACLV65_RS10245 WP_000866065.1 2092231..2092983(-) (comE) [Streptococcus mitis isolate S. mitis B22]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACAGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAACGATGAAGTAAATCAGC
TTTATTTCCTAGATATTGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAACGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTTTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTGGTGGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATCCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTACGTATTATTGGTAAGAATTTTGCCAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATTAGAG
AGATTGATCGAAAAAACCTAGAAATTGTTTTCTATGAAGATCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408